(4E)-4-(3,3,4-trimethylcyclopentylidene)butanal

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Experimental Dates: 18 September 2019 to 17 January 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

Commission Regulation (EC) No 440/2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

signed on 15 Nov. 2018

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

Actual storage conditions: Ambient temperature away from light. Kept in the original glass container.

Key result

Melting / freezing pt.:

< -20 °C

First Determination

Mass taken: 12.38 mg
During the cooling phase, some disturbances were observed around -110°C but no peak corresponding to freezing point was observed.
During the heating phase, a step from the baseline between -113.7°C and -110.5°C was observed, but no peak corresponding to the melting point was detected on the thermogram.
The crucible was visually checked after the determination: By opening the crucible, no sign of decomposition was observed.

Second Determination

Mass taken: 13.31 mg
During the cooling phase, some disturbances were observed around -110°C but no peak corresponding to freezing point was observed.
During the heating phase, a step from the baseline between -113.5°C and -110.8°C was observed, but no peak corresponding to the melting point was detected on the thermogram.
The crucible was visually checked after the determination: By opening the crucible, no sign of decomposition was observed.

Additional tests

To confirm the state of the test item near -20°C, a freezing limit test was performed. The test item was poured into a beaker and then placed in a freezer at about -20°C during 2 hours.
After 2 hours at -20°C, the test item remained liquid. The test item was placed anew in a freezer for three more days and remained liquid.

Executive summary:

The melting point of the test substance was determined under GLP according to OECD 102 / EU A1 guideline, using the DSC method.

Two main runs were performed, but no melting point/range of the substance was identified down to -120°C. Moreover the freezing limit test confirms that the test item remains liquid at -20°C.

Therefore the melting point/range of the test item is given as “< - 20°C”.

Description of key information

Both experimental melting point (i.e. transition from solid to liquid) and freezing point (i.e. transition from liquid to solid) < - 20°C.

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. It is considered as key study. As no transition was observed down to -20°C, the result is expressed as a limit value, and cannot be retained as key data.