Registration Dossier
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EC number: 939-368-0 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda was found to be stable in an OECD TG 111 study.
Key value for chemical safety assessment
Additional information
A GLP-compliant study, scored as Klimisch 1 and flagged as a key study, is available on the Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda. No deviation from the gudieline was observed in the study.
The hydrolysis of reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda was studied in accordance with the OECD Testing Guideline 111.
Samples were prepared at the following measured concentrations:
pH |
Concentration reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda (µg/mL) |
Concentration Mono (µg/mL) |
Concentration Di (µg/mL) |
Concentration Tri (µg/mL) |
4 |
17.23 |
3.54 |
7.38 |
2.66 |
7 |
17.27 |
3.55 |
7.39 |
2.66 |
9 |
17.31 |
3.56 |
7.41 |
2.67 |
The samples were incubated for 5 days at 50°C at pH 4.0, pH 7.0 and pH 9.0 sterile aqueous buffer solutions in dark conditions. At the beginning of the test and at the end of the test, duplicate samples were analyzed by High Performance Liquid Chromatography (HPLC) with UV detection to quantify the three components of interest of the test substance (sodium monoisopropylnaphthalenesulphonate, sodium diisopropylnaphthalenesulphonate and sodium triisopropylnaphthalenesulphonate) presents in the aqueous samples.
Less than 10% degradation of reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda was observed after 5 days incubation at 50.0 °C in sterile pH 4.0, pH 7.0 and pH 9.0 buffer samples. The sodium triisopropylnaphthalenesulphonate at pH 4 showed a drop of 10.91%; however this was not deemed significant when the standard error of the results and the concentration of this compound in the test item was taken into account.
The test substance was considered to be hydrolytically stable at pH 4.0, 7.0 and 9.0 and no additional testing was required or performed.
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