1H-Pyrazole-5-carboxamide, 4-[[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]benzoyl]amino]-1-methyl-3-propyl-

Guidance on Safe Use

First-aid measures

Description of First Aid Measures

Eye Contact: Flush with water while holding eyelids open for at least 15 minutes. Seek medical attention immediately.

Skin Contact: Remove contaminated clothing. Flush area with large amounts of water. Use soap. Seek medical attention.

Ingestion: Never give anything by mouth to an unconscious person. Wash out mouth with water. Do not nduce vomiting unless directed by medical personnel. Seek medical attention immediately.

Inhalation: Remove to fresh air and keep patient at rest. Seek medical attention immediately. Most Important Symptoms and Effects, Both Acute and Delayed

Symptoms and Effects of

Exposure: No data available

Medical Conditions Aggravated by Exposure:

None known

Indication of the Immediate Medical Attention and Special Treatment Needed

Notes to Physician: None

Fire-fighting measures

Extinguishing Media: Use carbon dioxide, dry chemical, or water spray.

Special Hazards Arising from the Substance or Mixture

Hazardous Combustion Products:

This material produces toxic fumes of nitrogen and sulfur oxides, carbon dioxide, and carbon monoxide during fires.

Fire / Explosion Hazards: Strong dust explosion characteristic. Very high sensitivity of a dust cloud to ignition, based on minimum ignition energy.

Advice for Fire-Fighters

During all fire fighting activities, wear appropriate protective equipment, including self-contained breathing apparatus.

Accidental release measures

Personal Precautions, Protective Equipment and Emergency Procedures

Personnel involved in clean-up should wear appropriate personal protective equipment (see Section 8). Minimize exposure.

Eliminate all sources of ignition and ventilate area using explosion-proof equipment.

Environmental Precautions

Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release.

Methods and Material for Containment and Cleaning Up

Measures for Cleaning / Collecting:

Contain the source of the spill if it is safe to do so. Collect spilled material by a method that controls dust generation. Clean spill area thoroughly. Avoid use of a filtered vacuum to clean spills of dry solids, due to the potential for electrostatic discharge and the strong dust explosion potential and very high sensitivity to ignition.

Additional Consideration for Large Spills:

Non-essential personnel should be evacuated from affected area. Report emergency

situations immediately. Clean up operations should only be undertaken by trained personnel.

Handling and storage

Precautions for Safe Handling

Ground and bond all bulk transfer equipment. Avoid open handling. Minimize dust generation. Use local exhaust ventilation or perform work under fume hood/fume cupboard. Avoid inhalation and contact with skin, eye, and clothing. When handling, use appropriate personal protective equipment (see Section 8). Wash hands and any exposed skin after removal of PPE. Eliminate possible ignition sources (e.g., heat, sparks, flame, impact, friction, electricity), and follow appropriate grounding and bonding procedures. Avoid contact with eyes, skin and clothing. Avoid breathing dust. Minimize dust generation and accumulation. Use

with adequate ventilation. Releases to the environment should be avoided. Review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure or environmental releases. Potential points of process emissions of this material to the atmosphere should be controlled with dust collectors, HEPA filtration systems or other equivalent controls. All conductive elements of the system that contact the dry substance should be properly bonded and grounded and equipped with proper explosion relief or suppression systems. This material should not be flowed through

nonconductive ducts or pipes because of the potential for electrostatic discharge ignition. Restricting the use of high resistivity materials, such as plastics, should be considered.

Conditions for Safe Storage, Including any Incompatibilities

Storage Conditions: Keep away from heat, sparks, flame, and other sources of ignition. Keep container tightly closed when not in use. Store out of direct sunlight in a well ventilated area at room

temperature.

Specific end use(s): Pharmaceutical process intermediate

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

ADR/RID Not regulated

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

ADN(R) Not regulated

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

IMDG Not regulated

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

IATA - International Air Transport Association: Not regulated.

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Control Parameters

Analytical Method: Analytical method available. Contact Pfizer Inc for further information.

Exposure Controls

Engineering Controls: Engineering controls should be used as the primary means to control exposures. Use process containment, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits.

Personal Protective Equipment:

Refer to applicable national standards and regulations in the selection and use of personal protective equipment (PPE).

Hands: Wear impervious gloves as minimum protection.

Eyes: Wear safety glasses as minimum protection.

Skin: Wear impervious protective clothing when handling this compound.

Respiratory protection: If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL.

Stability and reactivity

Reactivity: No data available

Chemical Stability: Stable under normal conditions of use.

Possibility of Hazardous Reactions

Oxidizing Properties: No data available

Conditions to Avoid: Keep away from heat and other sources of ignition, including electrostatic discharge.

Incompatible Materials: As a precautionary measure, keep away from strong oxidizers

Hazardous Decomposition Products: No data available

Disposal considerations

Dispose of waste in accordance with all applicable laws and regulations. Member State specific and Community specific provisions must be considered. Considering the relevant known environmental and human health hazards of the material, review and implement appropriate technical and procedural waste water and waste disposal measures to prevent occupational exposure and environmental release. It is recommended that waste minimization be practiced. The best available technology should be utilized to prevent environmental releases. This may include destructive techniques for waste and wastewater.