Registration Dossier
Registration Dossier
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EC number: 613-906-1 | CAS number: 66212-25-7
Endpoint summary
Administrative data
Description of key information
Oral (Rat, GLP, OECD TG 423): LD50 > 2000 mg/kg [Schering AG, Report No. X174 -draft-, 1996-10-21]
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September to October 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1981
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Doses:
- 2000 mg/kg (application volume 10 mL/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is of low oral toxicity.
- Executive summary:
The single oral administration of the test substance (ZK 5668) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs and effects on body weight were observed and there were no macroscopic pathological signs.
The acute oral toxicity of 1,4,6 -Trienol in rats is therefore above 2000 mg/kg body weight.
Reference
No animal died in the course of the study. Moreover, no clinical signs, no effects on body weight and body weight gain and no abnormalities at necropsy were observed.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
- Quality of whole database:
- Klimisch 1
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The single oral administration of the test substance (ZK 5668) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality.
No compound-related clinical signs and effects on body weight were observed and there were no macroscopic pathological signs.
The acute oral toxicity of 1,4,6 -Trienol in rats is therefore above 2000 mg/kg body weight.
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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