Registration Dossier
Registration Dossier
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EC number: 500-097-4 | CAS number: 37353-75-6 1 - 4.5 moles propoxylated
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to birds
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- It is laid down in the REACH Regulation EC 1907/2006 annex X, section 9.6.1., column 2, that "any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level”. This endpoint allows to consider potential secondary poisoning issues to birds following chronic exposure to BPA PO via the fish and earthworm food chains. BPA PO has a low potential for bioaccumulation and has no potential to cause toxic effects if the substance is accumulated in higher organisms via the food chain. In particular, according to CLP regulation EC 1272/2008, BPA PO is not considered H360, H361, H362, H372 or H373. BPA PO does not fulfil the T criterion of REACH regulation either. Considering all those elements, and in accordance with ECHA's guidance document R.16 on Environmental Exposure Assessment (v3.0; Feb 2016; pp. 24-25), one can safely conclude that there is no concern for secondary poisoning with BPA PO. Consequently, this study is not scientifically justified.
Reference
Description of key information
It is laid down in the REACH Regulation EC 1907/2006 annex X, section 9.6.1., column 2, that "any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level”. This endpoint allows to consider potential secondary poisoning issues to birds following chronic exposure to BPA PO via the fish and earthworm food chains. BPA PO has a low potential for bioaccumulation and has no potential to cause toxic effects if the substance is accumulated in higher organisms via the food chain. In particular, according to CLP regulation EC 1272/2008, BPA PO is not considered H360, H361, H362, H372 or H373. BPA PO does not fulfil the T criterion of REACH regulation either. Considering all those elements, and in accordance with ECHA's guidance document R.16 on Environmental Exposure Assessment (v3.0; Feb 2016; pp. 24-25), one can safely conclude that there is no concern for secondary poisoning with BPA PO. Consequently, this study is not scientifically justified.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
