2-amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide

Guidance on Safe Use

First-aid measures

Inhalation: Move to fresh air. Oxygen or artificial respiration if needed. If exposed or concerned: Get medical attention/advice

Eyes: Rinse immediately with plenty of water for at least 15 minutes. Keep eye wide open while

rinsing. Obtain medical attention.

Skin:If ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs, seek

medical advice/attention. Wash contaminated clothing before re-use.

Ingestion: IF SWALLOWED: Immediately call a POISON CENTRE or doctor/physician. Rinse

mouth.

Fire-fighting measures

Recommended extinguishing agent: Dry foam, powder and water spray. Do not use water jet.  Product arising from burning: Complete combustion will lead to the formation of oxides of

carbon, nitrogen and sulphur.  Reduced forms of these oxides

(eg. carbon monoxide) may result from combustion in enclosed spaces. Other possible combustion products

following incomplete oxidation may include gaseous hydrogen chloride.  Protective equipment: Full protective equipment including self-contained breathing

 apparatus, suitable gloves, goggles and face protection must

be worn.

Further Information: HCl gas can form flammable or explosive mixtures with alcohols or

metals. In the event of fire and/or explosion do not breathe fumes.

Decontaminate protective clothing and equipment before reuse. Avoid generating dust;

fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition

source is a potential dust explosion hazard.

Accidental release measures

Emergency measures in case of spillage: The affected area will be fenced or cordoned off and individuals will not be allowed to touch or walk through the spilled material unless wearing appropriate protective clothing. Dust generation will be avoided.   Suitable protective clothing will include gloves and eye/face protection. As a minimum this will include: tightly fitting safety goggles,, disposable lab coat of low permeability with cuffs,

double gloves, shoe covers, and an approved respirator. Depending upon the nature of the spill (quantity and extent of spill), additional protective clothing and equipment such as self-contained breathing apparatus may be needed.   Any dusts will be moistened to prevent generation of aerosols and covered with suitable material. The substance will be placed in a suitable properly labelled container for disposal according to local regulations.

Cleanup Methods Contain and collect spillage and place in container for disposal according to local

regulations (see Section 13). Use a HEPA vacuum or moisten materials to minimize dust

generation during pick-up. Clean area with detergent and water after spill pick-up, if

appropriate. Handle waste materials, including gloves, protective clothing, contaminated

spill cleanup material, etc., as appropriate for chemically and pharmacologically similar

material

Handling and storage

Handling Precautions Avoid exposure - obtain special instructions before use. Avoid formation of dust and

aerosols. Keep away from heat and sources of ignition. Prevent release to drains and

waterways. Use of inert gas should be considered to minimize the risk of ignition.

Minimize dust generation and accumulation. Routine housekeeping should be instituted to

ensure that dusts do not accumulate on surfaces. Dry powders can build static electricity

charges when subjected to the friction of transfer and mixing operations. Provide adequate

precautions, such as electrical grounding and bonding, or inert atmospheres.

Container Requirements: Store in sturdy containers appropriate to maintain the integrity of this material for its

Storage Conditions Store at room temperature. 15 - 30°C Protect against light. Keep away from heat, sparks

and flames. Store locked up.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN2811

Shipping information

Proper shipping name and description:

Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)

Chemical name:

Thiazolecarboxamide Derivative

Language:

English

Labels:

6.1

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN2811

Shipping information

Proper shipping name and description:

Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)

Chemical name:

Thiazolecarboxamide Derivative

Language:

English

Labels:

6.1

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN2811

Shipping information

Proper shipping name and description:

Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)

Chemical name:

Thiazolecarboxamide Derivative

Labels:

6.1

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN2811

Shipping information

Proper shipping name and description:

Toxic, solid, organic, n.o.s. (Thiazolecarboxamide Derivative)

Chemical name:

Thiazolecarboxamide Derivative

Labels:

6.1

Remarks

SpecialProvisions

Exposure controls / personal protection

Engineering Controls and Ventilation

Use process enclosures, containment technology, or other engineering controls to keep

airborne levels below recommended exposure limit. When handling quantities up to 15

milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air

changes per hour) is appropriate. When handling quantities from 15 milligrams to 1 kilogram,

work in a standard laboratory using a fume hood, biological safety cabinet(Class II, all types),

or approved vented enclosure. Quantities exceeding 1 kilogram should be handled in a

designated laboratory. A laminar flow/powder containment booth is recommended for

handling >1 kilograms of active substance. For manufacturing and pilot plant operations, use

direct coupling and closed transfer systems for all bulk transfers. Use dust tight valves as

appropriate. HEPA filtration of local exhaust ventilation (LEV) is required. It is

recommended that all dust control equipment such as local exhaust ventilation and material

transport systems involved in handling of this product contain explosion relief vents or an

explosion suppression system or an oxygen deficient environment. Ensure that dust-handling

systems (such as exhaust ducts, dust collectors, vessels, and processing equipment) are

designed in an manner to prevent the escape of dust into the work area (i.e., there is no leakage

from the equipment). Use only appropriately classified electrical equipment and powered

industrial trucks.

Respiratory protection

Use and selection of respiratory protection is based upon engineering controls in use and

potential for aerosol generation. When engineering controls are not sufficient control

exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate

(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure

control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying

respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control

guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters

(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting,

full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure

control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied

air respirator (EN 139) operated in a pressure demand or other positive pressure mode when

exposures are 100-1000 times the exposure control guideline.

Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety

goggles (EN 166) may be required if splash potential exists or if corrosive materials are

present. Note: Choice of eye protection may be influenced by the type of respirator which is

selected.

Hand protection Impervious nitrile, rubber and latex gloves are recommended. If material is handled in

solution, the solvent should also be considered when selecting protective clothing material.

Please note that employees who are allergic to natural rubber latex should use nitrile gloves.

Skin and body protection

Wear a laboratory coat when handling quantities up to 1 kilogram. For quantities over 1

kilogram, wear laboratory coat or coverall of low permeability. For manufacturing operations,

wear coverall of low permeability.

Wear a laboratory coat when handling quantities up to 1 kilogram. For quantities over 1

kilogram, wear laboratory coat or coverall of low permeability. For manufacturing operations,

wear coverall of low permeability.

Hygiene Wash hands and face before breaks and immediately after handling the product.

Stability and reactivity

Danger other than fire: None known. Stable under normal conditions

Chemical reaction with water: There is not considered to be any adverse reaction with wate

r.

Dust explosion: The material exhibits strong explosion

characteristics if ignited as a dust cloud (Kst 236

bar.m/sec).

The material is very susceptible to igniting as a dust cloud

under certain conditions due to low minimum ignition energy

(>10 - <25 mJ).

The material has low sensitivity to accumulating static

charges during processing (8.2E+13 ohm.m).

Charge decay time (ambient) 33 minutes

Ignition temperature >600°C

Powder handling equipment such as dust collectors, dryers

and mills may require additional protective measures (e.g.

explosion venting, inerting, etc.). Suitable bonding and

grounding containers and process equipment to control static

discharges and to control accumulation of static charges

will be provided. Use of inert gas will be considered to

minimize the risk of ignition.

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: Discharge to the environment will be minimal. Trace quantities are destroyed by biological oxidation in the on- site and local municipal wastewater treatment plants. Recovery of larger spillages of uncontaminated material for subsequent use is recommended. As material is used in the process, no recycling of material is possible.  Industry - Possibility of neutralisation: No method of neutralisation is known.  Industry - Possibility of destruction: controlled discharge: Trace quantities are destroyed by biological oxidation in wastewater treatment plants.  Industry - Possibility of destruction - incineration: Incineration is used as standard system for treating mother liquors. A closed-cycle incinerator with scrubbers should be employed.  National and local regulations must be observed.  Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to the sewage system or aqueous environment. However, there are unlikely to be adverse effects on sewage treatment systems, because the substance has been shown not to be unduly toxic to sewage microorganisms.  Industry - Possibility of destruction - other: None known