Matte, precious metal

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (sensitising)

Additional information:

Substance specific information for the UVCB substance "Matte, precious metal" is not available for the endpoint "Sensitisation". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as skin sensitiser that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.4.3.3 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool.

This approach has been presented and discussed with ECHA in several meetings.

In total, tree different grades of "Matte, precious metal" (Matte, precious metal 1 – Matte, precious metal 3) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile. Thus, for "Matte, precious metal" two C&L entries (i.e., no C&L and Skin Sens. 1) for skin sensitisation were calculated. Each group is described in a separate endpoint study record and endpoint summary.

Migrated from Short description of key information:
No information on animal testing of "Matte, precious metal" is available. Since, Matte, precious metal 2 – Matte, precious metal 3 contain constituents ≥ 1 % (i.e., nickel) that is itself classified for skin sensitisation; the substance requires classification as being a skin sensitiser, Skin Sens. 1 (H317). It is noted that no sub-categorisation was performed. For information on C&L for Matte, precious metal 1 please refer to the IUCLID endpoint summary "sensitisation - Matte, precious metal 1.

Respiratory sensitisation

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed (not sensitising)

Additional information:

Substance specific information for the UVCB substance "Matte, precious metal" is not available for the endpoint "Sensitisation". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as respiratory sensitiser that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.4.3.3 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool.

This approach has been presented and discussed with ECHA in several meetings.

In total, tree different grades of "Matte, precious metal" (Matte, precious metal 1 – Matte, precious metal 3) were identified by the consortium that could be grouped according to their calculated C&L resulting from the specific composition profile.Thus, for Matte, precious metal two C&L entries (i. e., no C&L and skin sensitising Cat. 1) for skin sensitisation were calculated. Each group is described in a separate endpoint study record and endpoint summary.

Migrated from Short description of key information:
No information on animal testing of "Matte, precious metal" is available. Since, Matte, precious metal 2 - Matte, precious metal 3 does not contain any constituent ≥ 0.1 % (w/w) that is itself classified for respiratory sensitisation, the substance does not require classification as respiratory sensitiser.

Justification for classification or non-classification

Skin sensitisation

Matte, precious metal 2 – Matte, precious metal 3 contain constituents ≥ 1 % (i.e., nickel) that is itself classified for skin sensitisation. Hence, Matte, precious metal 2 - Matte, precious metal 3 are skin sensitizerin accordance with Guidance on the application of the CLP criteria, Version 4.0 - November 2013 andmeet the classification criteria as skin sensitizer. Matte, precious metal 2 – Matte, precious metal 3 should be labelled with Skin Sens. Cat. 1 (H317) in accordance with Regulation (EC) 1272/2008.

Respiratory sensitisation

Furthermore, "Matte, precious metal" does not contain any constituent ≥ 0.1 % (w/w) that is itself classified for respiratory sensitisation. Hence, the substance does not require classification as respiratory sensitiser in accordance with Regulation (EC) 1272/2008.