Registration Dossier
Registration Dossier
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EC number: 283-479-0 | CAS number: 84649-98-9 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum zeylanicum, Lauraceae.
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 2650 mg/kg bw (standard acute method)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 650 mg/kg bw
Additional information
An acute oral toxicity was performed according to the standard acute method. Rats were treated with Cinnamon leaf oil by oral administration at 5 doses (1640, 2050, 2560, 3200, and 5000 mg/kg), 10 rats per dose. The animals were observed daily during test days 1-14, and mortality and clinical signs were recorded. Based on the results an LD50 of 2650 mg/kg bw was established.
A supporting study was available in which cinnamon leaf oil was administered dermally to New Zealand White rabbits. A limit dose of 5000 mg/kg bw did not result in mortality, and the LD50 was determined to be >5000 mg/kg bw.
Justification for classification or non-classification
Based on the available information, cinnamon leaf oil has been shown to be of low acute toxicity when applied via the oral and dermal route. Therefore, the substance cinnamon leaf oil does not need to be classified for acute toxicity according to the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
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