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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

No information on animal testing of Doré is available. However, Doré 1-Doré 2 does not meet classification criteria for STOT RE 1 or STOT RE 2.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Substance specific information for the UVCB substance Doré is not available for the endpoint "Repeated Dose Toxicity". In order to meet the requirements for Annex VII till Annex X of Regulation (EC) 1907/2006, read across information from any constituents being relevant needs to be included. Due to the high number of constituents and variability in C&L of these constituents it was decided to use the classification information from the individual constituents and to calculate the resulting classification by using the generic concentration limits of ingredients of the mixture classified as a specific target organ toxicant that trigger classification of the mixture and respective rules of Regulation (EC) 1272/2006 section 3.9.3.4 “Classification of mixtures when data are available for all components or only for some components of the mixture” with the MeClas tool. This approach has been presented and discussed with ECHA in several meetings.

In total five different Doré grades (Doré 1 – Doré 5) were identified by the consortium that could be grouped according to their calculated C&L resulting from the individual composition. Thus, for Doré two C&L entries (i.e., no C&L and STOT RE 2) for repeated dose toxicity were calculated. Each group is described in a separate endpoint study record and endpoint summary

Justification for classification or non-classification

Classification of UVCB substances as being toxic to specific target organs after repeated dosing is based on the presence of a constituent ≥ 1 % classified as STOT-RE 1 and of a constituent ≥ 10 % classified as STOT-RE 2, respectively. Since, Doré 1 - Doré 2 does not contain any constituents in concentrations relevant for C&L, Doré 1 - Doré 2 does neither meet classification criteria as STOT-RE 1 nor STOT-RE 2, in accordance with Regulation (EC) 1272/2008.