Registration Dossier
Registration Dossier
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EC number: 270-180-5 | CAS number: 68412-26-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 March 2016 to 25 September 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Purity: This substance has an Unknown or Variable composition, is a Complex reaction product, or a Biological material (UVCB).
- Description: Yellow powder
- Storage: Room temperature in the dark - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 6.24 - <= 7.28
- Temp.:
- 30 °C
- pH:
- 6.13
- Conclusions:
- Under the conditions of the study, the partition coefficient of the test material was determined to be in the range 1.74 x 10^6 to 1.89 x 10^7, log10 Pow 6.24 to 7.28, using the HPLC method.
- Executive summary:
Under the conditions of the study, the partition coefficient of the test material was determined to be in the range 1.74 x 106 to 1.89 x 107, log10 Pow 6.24 to 7.28, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and Method 830.7570 of the OCSPP Guidelines, August 1996.
Reference
Description of key information
Under the conditions of the study, the partition coefficient of the test material was determined to be in the range 1.74 x 106 to 1.89 x 107, log10 Pow 6.24 to 7.28, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and Method 830.7570 of the OCSPP Guidelines, August 1996.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.24
Additional information
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