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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Strontium substances have been tested in bacterial reverse mutation assays, in vitro gene mutation and chromosome aberration test.
- in-vitro gene mutation in bacteria (OECD 471): negative (no data is available for Sr(OH)2, thus read-across from SrCl2 to Sr(OH)2 was performed)
- in-vitro gene mutation in mammalian cells (OECD 476): negative (no data is available for Sr(OH)2, thus read-across from Sr(NO3)2 to Sr(OH)2 was performed)
- in-vitro chromosome aberration (OECD 473): negative (no data is available for Sr(OH)2, thus read-across from Sr(NO3)2 to Sr(OH)2 was performed)

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Genetic toxicity in vivo

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No genotoxicity study is available on Strontium hydroxide itself. However, an analogue approach is used for the read-across of genotoxicity properties of strontium hydroxide from strontium chloride or strontium nitrate, based on the hypothesis that properties are likely to be similar as a result of the presence of a common metal ion Sr2+. Further information on the read-across justification is included as attachment in Section 13.


The analogue approach was applied to the following endpoints:



  • Mutagenicity, in vitro gene mutation study in bacteria

  • Mutagenicity, in vitro cytogenicity study in mammalian cells or in vitro micronucleus study

  • Mutagenicity, in vitro gene mutation study in mammalian cells


It is concluded that strontium nitrate did not induce micronuclei in cultured human peripheral blood lymphocytes following treatments in the absence and presence of an Aroclor induced rat liver metabolic activation system (S-9 mix). Based on read-across the same is considered true for strontium hydroxide. Concentrations were tested and analysed up to 2116 µg/mL.


It is concluded that strontium nitrate did not induce mutation at the tk locus of L5178Y mouse lymphoma cells when tested under the conditions employed in this study . Based on read-across the same is considered true for strontium hydroxide.


These conditions included treatments up to precipitating concentrations in two independent experiments, in the absence and presence of a rat liver metabolic activation system (S-9 mix).


Further testing of in vivo genetic toxicity tests is not considered necessary.

Justification for classification or non-classification

Based on the read-across approach from strontium chloride or strontium nitrate, Strontium hydroxide is not expected to have mutagenicity / genotoxicity potential and no classification and labelling is required.