Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Neurotoxicity

Currently viewing:

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

Evidence for neurological activity of strontium was obtained from a number of in vitro investigations. In a calcium-free medium, strontium ions weakly supported the generation of excitatory postsysnaptic potentials following stimulation of guinea pig cervical ganglia (i.e., the release of acetylcholine was less efficient than when calcium was present) (s_McLachlan_1977). Incubation of vasa deferentia isolated from guinea pigs showed that both strontium and barium cations can substitute for calcium ions in the release of noradrenaline at adrenergic nerve terminals.


 


It was concluded that all these cations act through the same site at some stage in the process of potassium induced transmitter release (s_Nakazato_1980).Perfusion through acutely denerved cats´ adrenal glandsby strontium in calcium-free Locke´s solution resulted in an intense catecholamine secretion and restored the response to acetylcholine and excess potassium (s_Douglas_1964). Findings that the stimulating effect of strontium also persisted in glands perfused with EDTA led to the conclusion that strontium can substitute for calcium in the secretory process without liberation of endogeneous calcium from some intracellular binding sites. The sequestration of different divalent cations including strontium was examined, in comparison to calcium, by mitochondria and smooth endoplasmic reticulum from isolated presynaptic nerve terminals (s_Rasgado-Flores_1987). Strontium cations were less effective (by about 50 to 60%) than calcium ions.

Justification for classification or non-classification