Registration Dossier
Registration Dossier
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EC number: 240-841-2 | CAS number: 16812-54-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Freshwater:
High quality NOEC/L(E)C10values for chronic toxicity to freshwater fish are based on the fish species,Pimephales promelas,Oncorhynchus mykiss, andBrachydanio rerio. The NOEC/L(E)C10values for fish range from 40 μg/l forBrachydanio rerio(Dave & Xiu, 1991) to 15420 μg/l for theBrachydanio rerio(Kienle et al., 2009).
The following table indicates those NOEC or EC10 values that have been carried forward for the HC5-& PNEC derivation
Key Study (freshwater Fish) |
Selected values for the most sensitive endpoints used for derivation of the freshwater HC5 |
||
Species |
Endpoint |
Value (ug/L) |
|
Birge et al., 1984 |
Pimephales promelas |
NOEC |
57 |
Nebeker et al., 1985 |
Oncorhynchus mykiss |
NOEC |
134 |
Dave & Xiu., 1991 |
Brachydanio rerio |
NOEC |
40 |
Freshwater:
High quality NOEC/L(E)C10values for chronic toxicity to freshwater fish are based on the fish species,Pimephales promelas,Oncorhynchus mykiss, andBrachydanio rerio. The NOEC/L(E)C10values for fish range from 40 μg/l forBrachydanio rerio(Dave & Xiu, 1991) to 15420 μg/l for theBrachydanio rerio(Kienle et al., 2009).
Marine:
Chronic toxicity values are reported for marine fish species. EC10values range from 3599 μg Ni/L for growth of the topsmelt,Atherinops affinis(Huntet al., 2002), to 20760 μg Ni/L for growth of the sheepshead minnow,Cyprinodon variegates(GolderAssociates, 2007).
Key Study (marine Fish) |
Selected values for the most sensitive endpoints used for derivation of the marine HC5 |
||
Species |
Endpoint |
Value (ug/L) |
|
Golder, 2005 |
Cyprinodon variegatus |
EC10 |
20, 760 |
Hunt et al., 2002 |
Atherinops affinis |
EC10 |
3,599 |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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