Registration Dossier
Registration Dossier
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EC number: 235-747-3 | CAS number: 12650-88-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Expected non-toxic to microorganisms.
Key value for chemical safety assessment
Additional information
No specific data exists on the short-term toxicity to microorganisms.
However Lysozyme is naturally occurring in many organisms and exhibits a specific antimicrobial activity; nevertheless due to the high diversity of the sewage treatment plant microorganisms community, Lysozyme is not expected to be toxic to the STP.
The only data published available is reported in the HERA documentation on Subtilisins (Protease):
EC10 (exposure time unknown): 13,100 mg/L (not based on aep)[1 -2]
This data was reported as having a Klimisch score of 4 in the HERA document, thus not suitable for the aquatic toxicity assessment.
No published data are available on the effects of Lysozyme towards sewage treatment plant-relevant microorganisms; nevertheless as this enzymes are produced by bacteria as well as by fungi in nature, no adverse effects on other microorganisms are expected at environmentally relevant concentrations.
Reference
[1]HERA Human and environmental risk assessment on ingredients of household cleaning products - Subtilisins (Proteases). Edition 2.0. 2007.
[2] Schöberl P and Huber L, (1988) Ökologisch relevante Daten von nichttensidischen Inhaltsstoffen in Wasch- und Reinigungsmitteln. Tenside Detergents 3/4: 86-107 **
**Reported as Klimisch 4 in the HERA document.
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