Registration Dossier
Registration Dossier
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EC number: 235-747-3 | CAS number: 12650-88-3
Endpoint summary
Administrative data
Description of key information
Additional information
The general degradation pathway of proteins is a stepwise process starting with the splitting of peptide bonds in the protein polymer by proteolytic enzymes (proteases) forming lower-molecular oligopeptides, which are subsequently degraded by peptidases to the monomeric amino acids.
Physical effects like heating, dilution, mixing of solutions with air, etc. lead to denaturation, i.e. loss of activity and changes of the three-dimensional structure, which facilitates this proteolytical degradation process [1 and 2].
Considering the common chemical features of enzymes and their general evaluation as substances easily accessible to biodegradation, it is expected that possible abiotic degradation mechanisms will be of lower relevance for their environmental fate than biodegradation.
Furthermore the bioconcentration potential of enzymes can generally be neglected, considering the high molecular weight, the hydrophilic properties and their immediate accessibility to metabolic processes.
Considering the physical/chemical properties of enzymes and the mechanism of which they undergo, the adsorption/desorption coefficient as Henry's Law constant may be considered as negligible descriptors.
Reference
[1] HERA Human and environmental risk assessment on ingredients of household cleaning products - alpha-amylases, cellulases and lipases. 2005.
[2] HERA Human and environmental risk assessment on ingredients of household cleaning products - Subtilisins (Proteases). Edition 2.0. 2007.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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