Registration Dossier
Registration Dossier
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EC number: 230-597-5 | CAS number: 7212-44-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Key study for skin irritation:
Semiocclusive dermal application of 0.5 ml trans-Nerolidol (CAS 40716-66-3)
for 4 hours (BASF18H0193/872169):- Erythema were found in 1/3 animals with a mean score greater or equal to 2 (reading time points 24-48-72 h)
- Edema were found in 0/3 animals (at reading time points 24-48-72 h)
- Erythema reactions were reversible in all animals but scaling was observed at the end of the observation period of 8 days in 2/3 animals.
Key study for eye irritation:
0.1 ml of trans-Nerolidol (CAS 40716-66-3)
administered into conjunctival sac; substance was not washed out; observation period 8 days (BASF11H0193/872170):- Corneal reactions were observed in 2/3 animals with a score = 1 (reading time points 24-48-72 h), fully reversible within 8 days
- Iris reactions were observed in 1/3 animals with a score = 1 (reading time points 24-48-72 h), fully reversible within 8 days
- Conjunctivae score was 0.67, 1.67 and 2.0, respectively for the 3 animals (reading time points 24-48-72 h), fully reversible in all 3 animals at least within 8 days
- Chemosis was observed in 2/3 animals with a score = 0.33 (reading time points 24-48-72 h), fully reversible within 48 h.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
The present data on skin do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC, and therefore, a non-classification is warranted.
The present data on eye irritation do not fulfill the criteria laid down in 67/548/EEC. According to 1272/2008/EEC, a classification as "eye irritant" (Category 2) is warranted.
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