Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-496-2 | CAS number: 3923-79-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
There are no toxicokinetic studies available with 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one. The following toxicokinetic assessment is based on the available information on physico-chemical parameters and results from other (eco)toxicity studies with 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one:
4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one is manufactured and handled in aqueous solution with an experimentally determined vapour pressure of 23,9 hPa at 20 °C (Note: The vapour pressure of water is about 23 hPa at 20°C), whereas the pure substance is a white hard paste solid liquid with a negligible vapour pressure of 0.000000153 hPa at 20°C (calculated).
4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one has a molecular weight of 146 g/mol, is miscible in water at any ratio, and has a low log Pow of -3.93 at 25°C (calculated).
An acute oral toxicity studies in rats provided no evidence for systemic availability of 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one by the oral route (no mortality, clinical symptoms or gross pathological abnormalities observed.
In an acute dermal toxicity study in rabbits with 24-hour exposure to undiluted 4,5-Dihydroxy-1,3-dimethylimidazolidin-2-one under an occlusive coverage no mortality or signs of systemic toxicity were observed. Upon removal of the binders from the animals, the exposed area and binder appeared dry with no sample apparent on any of the animals. This observation provides evidence for dermal absorption of the substance.
The negative result of an in vitro genotoxicity study in bacteria (Ames test) with and without metabolic activation indicates that no reactive metabolites have been formed after incubation of the substance with rat liver S9 mix.
Based on the log Pow of -3.93 accumulation of the substance in organisms is not to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
