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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30 January - 21 February 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
EC No. 440/2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
EC Number:
222-468-7
EC Name:
(R*,R*)-1,4-dimercaptobutane-2,3-diol
Cas Number:
3483-12-3
Molecular formula:
C4H10O2S2
IUPAC Name:
1,4-disulfanylbutane-2,3-diol
Specific details on test material used for the study:
Batch No.: 44606300 / 50774
Storage Conditions: 2°C to 8°C, under nitrogen

Results and discussion

Melting / freezing point
Key result
Melting / freezing pt.:
42.44 °C
Atm. press.:
>= 1 000.7 - <= 1 001.7 hPa
Decomposition:
no

Any other information on results incl. tables

During the heating phase a distinct endothermic effect was observed in the temperature range of 40 – 60°C, which can be assigned to the melting of the test item. As the onset temperatures in both tests deviate by less than 0.5 K from their mean value of 42.44°C, this temperature can be used as melting point. The test item has a melting point of 42.4 °C.

Results of the DSC-measurement

No.   Sample weight/mg Onset of Effect/°C   Range of Effect/°C Weight loss/mg   Atmosperhic Presure/HPa
 PN19051  8.91  42.28
271.83		  40 – 60 (endo)
250 – 320 (endo)		  8.91  1000.7
 PN19053  8.35  42.60
269.71		  40 – 60 (endo)
250 – 320 (endo)		  8.34 1001.7

Applicant's summary and conclusion

Conclusions:
The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).
Executive summary:

The test item 1,4-Dithiothreitol (CAS no. 3483-12-3) has a melting point of 42.4°C at atmospheric pressure (1001 – 1002 hPa) as determined by differential scanning calorimetry according to Regulation EC No 440/2008 Method A.1. and OECD Test Guideline 102 (1995).