Registration Dossier
Registration Dossier
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EC number: 208-933-7 | CAS number: 547-67-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Three studies are used for the derivation of an acute toxicity reference value (Parametrix 2005a; Parametrix 2005b; Schubauer-Berigan et al.,1993) at pH 6 and 8. These studies have demonstrated that nickel toxicity increases with pH; therefore, acute toxicity values for pH ca. 8.0 are used for derivation of the toxicity reference value. The testing conditions (pH 8.3 – 8.7 and hardness of 258 – 290 mg/L as CaCo3) in these studies were sufficiently similar to allow for statistical analysis of the results. The geometric mean of 6 LC50 values was 0.068 mg Ni/L or 68 µg Ni/L (see table below).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 68 µg/L
Additional information
Acute Toxicity Data for Ceriodaphnia dubia Used for Deriving the Acute Toxicity Reference Value |
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Reference |
Substance Tested |
pH |
Hardness (mg/L as CaCO3) |
LC50 (48 hr) (mg Ni/L) |
Schubauer-Berigan et al., 1993 |
NiCl2 |
8.7 |
290 |
0.013 |
Parametrix, 2005a |
NiCl2 |
8.3 |
258 |
0.074 |
|
NiCl2 |
8.4 |
266 |
0.088 |
Parametrix, 2005b |
NiCl2 |
8.4 |
280 |
0.082 |
|
NiCl2 |
8.7 |
290 |
0.13 |
|
NiCl2 |
8.5 |
290 |
0.11 |
LC50 Geometric Mean under similar testing conditions |
0.068 |
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