Disodium succinate

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Remarks:

aquatic organisms

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from handbook and secomdary source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Environmental bioconcentration factor of the test chemical was estimated using a logKow and a BCFWIN v. 2.14 program.

GLP compliance:

not specified

Radiolabelling:

not specified

Vehicle:

not specified

Test organisms (species):

other: aquatic organisms

Route of exposure:

aqueous

Test type:

not specified

Water / sediment media type:

natural water: freshwater

Reference substance (positive control):

not specified

Details on estimation of bioconcentration:

BASIS FOR CALCULATION OF BCF
- Result based on calculated logKow of: -0.59

Key result

Type:

BCF

Value:

3.2 dimensionless

Basis:

whole body w.w.

Calculation basis:

other: BCF value of test chemical was estimated using a logKow and a BCFWIN v. 2.14 program.

Remarks on result:

other: Other details not known

According to a classification scheme, the BCF value of test chemical suggests the potential for bioconcentration in aquatic organisms is low.

Validity criteria fulfilled:

not specified

Conclusions:

The estimated BCF (bioaccumulation factor) of test chemical was determined to be 3.2 dimensionless.

Executive summary:

The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of -0.59 and a BCFWIN v. 2.14 program. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3.2 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Description of key information

The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (from handbook (2008) & secondary source (2003)). The bioaccumulation factor (BCF) value was calculated using a logKow of -0.59 and a BCFWIN v. 2.14 program. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3.2 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-accumulative in aquatic organisms.

Key value for chemical safety assessment

BCF (aquatic species):

3.2 dimensionless

Additional information

Various experimental key & supporting studies of the test chemical and experimental study of the structurally similar read across chemical were reviewed for the bioaccumulation end point which are summarized as below:

 

In an experimental key study from handbook (2008) & secondary source (2003), the bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of -0.59 and a BCFWIN v. 2.14 program. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3.2 dimensionless.

 

In a prediction done using the BCFBAF Program of Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).

 

From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application)  V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test chemical was estimated to be 3.89 dimensionless . The predicted BCF result based on the 5 OECD principles.

 

For the test chemical from authoritative database (2017), the BCF value of test chemical estimated was 1.0 dimensionless by using a water solubility of 385000 mg/L and a regression-derived equation.

 

On the basis of above results for test chemical, it can be concluded that the BCF value of test chemical was evaluated to beupto3.89,which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is not expected to bioaccumulate in the food chain.