Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.46 µg/L
Assessment factor:
10
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.46 µg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.046 µg/L
Assessment factor:
100
Extrapolation method:
assessment factor
PNEC marine water (intermittent releases):
0.46 µg/L

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
0.06 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.105 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.011 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.147 mg/kg soil dw
Assessment factor:
50
Extrapolation method:
assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
PNEC oral
PNEC value:
16.67 mg/kg food
Assessment factor:
30

Additional information

Conclusion on classification

Conclusion on classification

 

Classification related key information

 

Biodegradation:

not readily biodegradable (30% after 28 d, OECD 310)

 

Bioaccumulation:

log Pow: 1.8 - 2.1

 

Aquatic acute toxicity:

Fish: LC50 (96 h) = 0.046 mg a.i./L (meas. initial, OECD 203, static, Oncorhynchus mykiss)

Aquatic invertebrates: EC50 (48 h) = 139 µg a.i./L (mean measured, OECD 201, flow-through, Daphnia magna)

Algae: ErC50 (72 h): > 141 µg a.i./L (geometric mean, OECD 201, static, Pseudokirchnerella subcapitata)

 

Aquatic chronic toxicity:

Fish: NOEC (33 d, survival and growth): 4.6 µg a.i./L (mean measured, OECD 210, flow-through, Pimephales promelas)

Aquatic invertebrates: NOEC (21 d, survival and reproduction) = 20 µg a.i./L (mean measured, OECD 211, flow-through, based on growth of Daphnia magna)

Algae: ErC10 (72 h, growth rate): 56.9 µg a.i./L (geometric mean, OECD 201, static, Pseudokirchnerella subcapitata)

 

Classification according to CLP

Based on data above, tetramethylthiuram disulfide (CAS No. 137-26-8) is not readily biodegradable (30% biodegradation after 28 d). Acute and chronic toxicity data are available for three trophic levels i.e. fish, algae and aquatic invertebrates. Fish were found to be the most sensitive trophic level in short-term and long-term tests with an LC50 (96 h) of 0.046 mg a.i./L (meas. initial) for mortality and a NOEC (33 d) of 4.6 µg a.i./L (mean measured) for survival and growth. The classification and labelling is based on harmonised classification (Annex VI, Regulation (EC) 1272/2008, Index-No: 006-005-00-4 and on own hazard assessment). Therefore, the substance needs to be classified as Aquatic Chronic 1 (H410) with an M-factor of 10 and Aquatic Acute 1 (H400) with an M-factor of 10 according to the consolidated version of Regulation (EC) No 1272/2008 and further amendments (ATPs).