Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-605-7 | CAS number: 97-74-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- "slight modifications" is indicated
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The daphnids were fed on 1 x 10^8 cells.L- 1 C. pyrenoidosa
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2.9 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mortality
- Remarks on result:
- other: (2.3 - 3.6)
- Reported statistics and error estimates:
- LC50 values and their 95% confidence intervals were calculated according to the Litchfield and Wilcoxon (1949) method.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The toxicity of tetramethylthiuram monosulphide to Daphnia magna was assessed according to the OECD 202 guideline with semi-static conditions. LC50 -48h was determined to be equal to 2.9 mg/L.
- Executive summary:
The toxicity of tetramethylthiuram monosulphide to Daphnia magna was assessed according to the OECD 202 guideline with semi-static conditions. LC50 -48h was determined to be equal to 2.9 mg/L.
Reference
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.9 mg/L
Additional information
- EC50-48h: 2.9 mg/L
- EC50-48h: 1.6 mg/L
The acute toxicity of tetramethylthiuram monosulphide to Daphnia magna was assessed through several studies for which the followings EC50-48h were determined:
The last data is mentioned in the HPV dossier Thiuram, but as the study belongs to another company, the tox data is considered as supporting data. Thus, the "key data" is EC50-48h = 2.9 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
