Registration Dossier
Registration Dossier
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EC number: 200-261-2 | CAS number: 56-18-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Based on the GHS, no chronic toxicity is anticipated at an NOEC or EC10 > 1 mg/L.
Key value for chemical safety assessment
Additional information
Experimental data on the chronic toxicity of 3,3'-iminodi(propylamine) (CAS 56-18-8) on aquatic invertebrates are not available.
Read-across data on long-term toxicity are available from a GLP study according to EU method C.20 (Daphnia magna reproduction test) with the structural analogous substance DETA (CAS 111-40-0). The 21-d NOEC was determined to be 5.6 mg/L (nominal; Akzo, 1991). The concentrations were not analytically verified during the test, but DETA is expected to be stable, due to a high water solubility (miscible), a moderate vapour pressure (VP = 0.35 Pa @20°C, measured) and a low Henry's Law Constant (HLC = 3.14 E-08 Pa m³/mol @ 25°C, calculated with HENRYWIN v3.20, not in applicability domain).
The key study is supported by an OECD 211 GLP-guideline study (ECHA database entry, without detailed documentation) with the structural analogous substance 1,2 -Ethanediamine, N,N'-bis(2 -aminoethyl)- (CAS 112 -24 -3), providing a 21-d EC10 of 1.9 mg/L.
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