Annex III inventory
Annex III inventory
Annex III inventory
ECHA compiled an inventory of substances likely to meet the criteria of Annex III to the REACH Regulation. The aim is to support registrants in identifying whether reduced minimum information requirements or a full Annex VII information set is required.
The inventory was produced using publicly available databases with experimental data and by using (Q)SAR model results. Indications for hazardous toxicological or ecotoxicological properties together with information on uses and other available relevant information have to be compared with the criteria in Annex III.
The fact that a substance is not in this list does not necessarily mean that the criteria for Annex III are not met. Likewise, if a substance is on this inventory, a registrant can still benefit from the reduced information requirements if it is justified.
Note that the inventory is not a tool for classification, it only shows indications for concern. For instance, the fact that a substance is indicated as "Suspected mutagen" does not mean that ECHA considers it as a classified mutagen. All evidence should be taken into account before concluding on the need for classification.
4-bromobiphenyl
EC / List no.: 202-176-6 CAS no.: 92-66-0| Information source | # Suspected bioaccumulative: KNN BCF model in VEGA (Q)SAR platform predicts a BCF of 3.48 log(L/kg) (moderate reliability); EpiSuite data included in the Toolbox contain at least one experimental log Kow value equal to or higher than 4.5;The Danish QSAR database contains information indicating that the substance is predicted as bioaccumulative (BCF > 2000 L/kg) # Suspected carcinogen: CAESAR Carcinogenicity model in VEGA (Q)SAR platform predicts that the chemical is Carcinogen (good reliability) # Suspected hazardous to the aquatic environment: EPA Daphnia Magna toxicity model in VEGA (Q)SAR platform predicts that the chemical has a 48h EC50 of 0.2633 mg/L (good reliability); Fathead Minnow toxicity model (EPA) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 3.55 mg/L (good reliability); Fish toxicity classification (SarPy/IRFMN) model in VEGA (Q)SAR platform predicts that the chemical is Toxic-2 (between 1 and 10 mg/l) (good reliability); Fish Acute Toxicity model (KNN/Read-Across) in VEGA (Q)SAR platform predicts that the chemical has a 96h LC50 of 5.02 mg/L (moderate reliability);The Danish QSAR database contains information indicating that the substance has a 48h EC50 to Daphnia of <1 mg/L # Suspected persistent in the environment: Ready biodegradability model (IRFMN) in VEGA (Q)SAR platform predicts that the chemical is NON Readily Biodegradable (moderate reliability);The Danish QSAR database contains information indicating that the substance is predicted as non readily biodegradable # Suspected skin irritant: The Danish QSAR database contains information indicating that the substance is predicted as skin irritant # Suspected toxic for reproduction: CAESAR developmental toxicity model in VEGA (Q)SAR platform predicts that the chemical is Toxicant (moderate reliability) |
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