EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

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Last updated 01 December 2023. Database contains 4658 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
Other bunyaviridae known to be pathogenic
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Other Caliciviridae
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Other flaviviruses known to be pathogenic
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Other hantaviruses
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Other known alphaviruses
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Other LCM-Lassa complex viruses
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Other Tacaribe complex viruses
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
ouabain
211-139-3
630-60-4
Acute Tox. 3; STOT RE 2
oxadiargyl (ISO); 3-[2,4-dichloro-5-(2-propynyloxy)phenyl]-5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2(3H)-one
254-637-6
39807-15-3
Repr. 2; STOT RE 2
oxalic acid
205-634-3
144-62-7
Acute Tox. 4
oxalic acid diethylester; diethyl oxalate
202-464-1
95-92-1
Acute Tox. 4; Eye Irrit. 2
oxalic acid, nickel salt
243-867-2
20543-06-0
Carc. 1A; STOT RE 1; Skin Sens. 1
oxalonitrile; cyanogen
207-306-5
460-19-5
Press. Gas; Flam. Gas 1; Acute Tox. 3
oxamyl (ISO); N',N'-dimethylcarbamoyl(methylthio)methylenamine N-methylcarbamate
245-445-3
23135-22-0
Acute Tox. 2; Acute Tox. 4
oxasulfuron (ISO); oxetan-3-yl 2-[(4,6-dimethylpyrimidin-2-yl)-carbamoylsulfamoyl]benzoate
604-430-5
144651-06-9
STOT RE 2
oxirane, mono[(C12-14-alkyloxy)methyl] derivs.
271-846-8
68609-97-2
Skin Irrit. 2; Skin Sens. 1
oxiranemethanol, 4-methylbenzene-sulfonate, (S)-
DAISO CCS-1S-E; S-GLYTO
417-210-7
70987-78-9
Carc. 1B; Muta. 2; Eye Dam. 1; Skin Sens. 1
oxo-((2,2,6,6-tetramethylpiperidin-4-yl)amino)carbonylacetohydrazide
LUCHEM HA-R 100; LUPERSOL HA-R 100
413-230-5
122035-71-6
Eye Dam. 1; Skin Sens. 1
oxycarboxin (ISO); 2,3-dihydro-6-methyl-5-(N-phenylcarbamoyl)-1,4-oxothiine 4,4-dioxide
226-066-2
5259-88-1
Acute Tox. 4
oxydemeton-methyl; S-2-(ethylsulphinyl)ethyl O,O-dimethyl phosphorothioate
206-110-7
301-12-2
Acute Tox. 3
oxydiethylene bis(chloroformate)
203-430-9
106-75-2
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
oxydiethylene dinitrate; diethylene glycol dinitrate; digol dinitrate;oxydiethylene dinitrate; diethylene glycol dinitrate; digol dinitrate [>25 % phlegmatiser]
211-745-8
693-21-0
Expl. 1.1; Acute Tox. 2; Acute Tox. 1; STOT RE 2
oxydiethylene dinitrate; diethylene glycol dinitrate; digol dinitrate;oxydiethylene dinitrate; diethylene glycol dinitrate; digol dinitrate [>25 % phlegmatiser]
211-745-8
693-21-0
Unst. Expl.; Acute Tox. 2; Acute Tox. 1; STOT RE 2
oxydisulfoton (ISO); O, O-diethyl S-2-ethylsulphinylethyl phosphorodithioate
219-679-1
2497-07-6
Acute Tox. 2; Acute Tox. 3
oxygen
231-956-9
7782-44-7
Ox. Gas 1; Press. Gas
p-anisidine; 4-methoxyaniline
203-254-2
104-94-9
Acute Tox. 2; Acute Tox. 1; STOT RE 2
p-benzoquinone; quinone
203-405-2
106-51-4
Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
p-cresol
203-398-6
106-44-5
Acute Tox. 3; Skin Corr. 1B
p-mentha-1,3-diene; 1-isopropyl-4-methylcyclohexa-1,3-diene; alpha-terpinene
202-795-1
99-86-5
Flam. Liq. 3; Acute Tox. 4; Skin Sens. 1; Asp. Tox. 1
p-nitroaniline
202-810-1
100-01-6
Acute Tox. 3; STOT RE 2
p-phenylenediamine
203-404-7
106-50-3
Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
p-toluenesulphonic acid (containing a maximum of 5 % H2SO4);p-toluenesulphonic acid, (containing more than 5 % H2SO4)
203-180-0
104-15-4
Skin Corr. 1B
p-toluenesulphonic acid (containing a maximum of 5 % H2SO4);p-toluenesulphonic acid, (containing more than 5 % H2SO4)
203-180-0
104-15-4
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
p-toluidine; 4-aminotoluene
203-403-1
106-49-0
Carc. 2; Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
p-tolyl 4-chlorobenzoate
UP 565
411-530-0
15024-10-9
Skin Sens. 1
p-xylene
203-396-5
106-42-3
Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2
paclobutrazol (ISO); (2RS,3RS)-1-(4-chlorophenyl)-4,4-dimethyl-2-(1H-1,2,4-triazol-1-yl)pentan-3-ol
616-379-6
76738-62-0
Repr. 2; Acute Tox. 4; Eye Irrit. 2
papain
232-627-2
9001-73-4
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
papaverine
200-397-2
58-74-2
Acute Tox. 4
Paracoccidioides brasiliensis
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F Fungi
Paraffin oils (petroleum), catalytic dewaxed heavy; Baseoil — unspecified [A complex combination of hydrocarbons obtained from a catalytic dewaxing process. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil with a viscosity of at least 100 SUS at 100 °F (19cSt at 40 °C).]
A complex combination of hydrocarbons obtained from a catalytic dewaxing process. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil with a viscosity of at least 100 SUS at 100°F (19cSt at 40°C).
265-174-4
64742-70-7
Carc. 1B
Paraffin oils (petroleum), catalytic dewaxed light; Baseoil — unspecified [A complex combination of hydrocarbons obtained from a catalytic dewxing process. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C15 through C30 and produces a finished oil with a viscosity of less than 100 SUS at 100 °F (19cSt at 40 °C).]
A complex combination of hydrocarbons obtained from a catalytic dewaxing process. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C15 through C30 and produces a finished oil with a viscosity of less than 100 SUS at 100°F (19cSt at 40°C).
265-176-5
64742-71-8
Carc. 1B
Paraffin oils (petroleum), solvent-refined dewaxed heavy; Baseoil — unspecified [A complex combination of hydrocarbons obtained from sulfur-containing paraffinic crude oil. It consists predominantly of a solvent refined deparaffinated lubricating oil with a viscosity of 65cSt at 50 °C.]
A complex combination of hydrocarbons obtained from sulfur-containing paraffinic crude oil. It consists predominantly of a solvent refined deparaffinated lubricating oil with a viscosity of 65cSt at 50°C.
295-810-6
92129-09-4
Carc. 1B
Paraffin waxes (coal), brown-coal high-temp tar, clay-treated; Coal Tar Extract [A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with bentonite for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with bentonite for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.
308-297-1
97926-77-7
Carc. 1B
Paraffin waxes (coal), brown-coal high-temp tar, silicic acid-treated; Coal Tar Extract [A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with silicic acid for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with silicic acid for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.
308-298-7
97926-78-8
Carc. 1B
Paraffin waxes (coal), brown-coal high-temp. tar, carbon-treated; Coal Tar Extract [A complex combination of hydrocarbons obtained by the treatment of lignite carbon ization tar with activated carbon for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with activated carbon for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.
308-296-6
97926-76-6
Carc. 1B
Paraffin waxes (coal), brown-coal-high-temp. tar, hydrotreated; Coal Tar Extract [A complex combination of hydrocarbons obtained from lignite carbonization tar by solvent crystallisation (solvent deoiling), by sweating or an adducting process treated with hydrogen in the presence of a catalyst. It consists predomi nantly of straight and branched chain saturated hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained from liqnite carbonization tar by solvent crystallisation (solvent deoiling), by sweating or an adducting process treated with hydrogen in the presence of a catalyst. It consists predominantly of straight and branched chain saturated hydrocarbons having carbon numbers predominantly greater than C12.
295-455-7
92045-72-2
Carc. 1B
Paraffin waxes (coal), brown-coal-high-temp. tar; Coal Tar Extract [A complex combination of hydrocarbons obtained from lignite carbonization tar by solvent crystallisation (solvent deoiling), by sweating or an adducting process. It consists predominantly of straight and branched chain saturated hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained from liqnite carbonization tar by solvent crystallisation (solvent deoiling), by sweating or an adducting process. It consists predominantly of straight and branched chain saturated hydrocarbons having carbon numbers predominantly greater than C12.
295-454-1
92045-71-1
Carc. 1B
Paragonimus westermani
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P Parasites
Parainfluenza viruses types 1 to 4
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V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
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