EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

Last updated 16 April 2024. Database contains 4691 unique substances/entries.

Filter the list

Showing 1 - 100 of 4,691 results.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)
'amyl nitrite', mixed isomers	203-770-8	110-46-3	Flam. Liq. 2; Acute Tox. 4
((4-phenylbutyl)hydroxyphosphoryl)acetic acid SQ 26999	412-170-7	83623-61-4	STOT RE 2; Eye Dam. 1; Skin Sens. 1
(+)-(1S, 2S, 3S, 5R)-2,6,6-trimethylbicyclo[3.1.1]heptane-3-spiro-1'-(cyclohex-2'-en-4'-one)	430-460-1	133636-82-5	Skin Corr. 1B; Skin Sens. 1
(+/-)-(R,R)-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran; 6-fluoro-2-(2-oxiranyl)chromane	606-373-1	197706-50-6	Skin Sens. 1
(-)(3S, 4R)-4-(4-fluorophenyl)-3-(3,4-methylenedioxy-phenoxymethyl)-N-benzylpiperidine hydrochloride	432-360-3	105813-13-6	Acute Tox. 4; Skin Sens. 1
(-)-trans-4-(4'-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine BRL 29226	406-030-4	105812-81-5	Acute Tox. 4; Eye Dam. 1
(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)methyl (1R-trans)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate	214-619-0	1166-46-7	Carc. 2; Acute Tox. 4; STOT SE 2
(1-hydroxydodecylidene)diphosphonic acid KELCOR; LIPOKEL; SEQUOL	425-230-2	16610-63-2	Skin Corr. 1B
(1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate	256-032-2	42978-66-5	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
(1R, 4R)-4-methoxy-2,2,7,7-tetramethyltricyclo(6.2.1.0(1,6))undec-5-ene	444-480-3	676125-00-1	Skin Irrit. 2
(1R,2S,5R)-2-[(4-chlorophenyl)methyl]-5-propan-2-yl-1-(1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol	-	115850-69-6	Repr. 1B; Acute Tox. 4; STOT RE 2
(1R,2S,5S)-2-[(4-chlorophenyl)methyl]-5-propan-2-yl-1-(1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol	-	115937-89-8	Repr. 1B; Acute Tox. 4; STOT RE 2
(1R,3S,7R,8R,10R,13R)-5,5,7,9,9,13-hexamethyl-4,6-dioxatetracyclo[6.5.1.01,10.03,7]tetradecane	427-580-1	211299-54-6	Skin Irrit. 2
(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one 1418U90	418-530-1	79200-56-9	Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
(1S)-2-methyl-2,5-diazobicyclo[2.2.1]heptanes dihydrobromide CP-84,203-4; DFX-5S	411-000-9	125224-62-6	Skin Sens. 1
(1S,3S,5R,6R)-(4-nitrophenylmethyl)-1-dioxo-6-phenylacetamido-penam-3-carboxylate P-NITROBENZYLESTER PGSO	412-670-5	54275-93-3	Resp. Sens. 1
(1S,4R,6R,7R)-(4-nitrophenylmethyl)3-methylene-1-oxo-7-phenylacetamido-cepham-4-carboxylateido-penam-3-carboxylate G-EXOMETHYLENE SULFOXIDE ESTER	412-800-0	76109-32-5	Resp. Sens. 1
(1S-cis)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride	426-200-1	172015-79-1	STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine 2-hydroxy-2-phenylacetate SERTRALINE STEP 2	420-560-3	79617-97-3	Eye Dam. 1
(1α,2α,3β,6β)-1,2,3,6-tetrahydro-3,6-methanophthalic anhydride	220-384-5	2746-19-2	Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
(1α5α6α)-6-nitro-3-benzyl-3-azabicyclo[3.1.0]hexane methanesulfonate salt CP-141,845-27	426-740-8	256369-40-1	Acute Tox. 4; Eye Dam. 1
(2,2'-(3,3'-dioxidobiphenyl-4,4'-diyldiazo)bis(6-(4-(3-(diethylamino)propylamino)-6-(-3-(diethylammonio)propylamino)1,3,5-triazin-2-ylamino)-3-sulfonato-1-naphtholato))dicopper(II) acetate lactate BLUE 10 25 964	407-240-9	159604-94-1	Skin Sens. 1
(2,3,5,6-tetrafluorophenyl)methanol	443-840-7	4084-38-2	Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
(2,3-dimethylbut-2-yl)-trimethoxysilane	439-360-2	142877-45-0	Skin Irrit. 2; Eye Dam. 1
(2,4-diaminopteridin-6-yl)methanol hydrobromide	430-620-0	76145-91-0	STOT RE 2; Skin Sens. 1
(2,5-dioxopyrrolidin-1-yl)-9H-fluoren-9-ylmethyl carbonate	433-520-5	82911-69-1	Acute Tox. 4; Skin Sens. 1
(2,6-xylyloxy) acetic acid	430-910-7	13335-71-2	Acute Tox. 4; Eye Dam. 1
(2-(1,3-dioxolan-2-yl)ethyl)triphenylphosphonium bromide DWS	404-940-6	86608-70-0	Acute Tox. 4; Eye Dam. 1; STOT RE 2
(2-(aminomethyl)phenyl)acetylchloride hydrochloride X-17-17	417-410-4	61807-67-8	Acute Tox. 4; Skin Corr. 1A; Skin Sens. 1
(2-butyl-5-nitrobenzofuran-3-yl)[4-(3-dibutylaminopropoxy)phenyl]methanone BUTAMINONITRODARONE; SR33581	444-800-1	141645-23-0	Flam. Liq. 3; Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
(2-chloroethyl)(3-hydroxypropyl)ammonium chloride CLETOPROPAMINHYDROCHLORID	429-740-6	40722-80-3	Carc. 1B; Muta. 1B; STOT RE 2; Skin Sens. 1
(2-ethylhexanoato-O)(isodecanoato-O)nickel	284-351-7	84852-39-1	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(2-ethylhexanoato-O)(isononanoato-O)nickel	287-470-2	85508-45-8	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(2-methylpropyl)lithium; isobutyllithium	440-620-2	920-36-5	Water-react. 1; Pyr. Liq. 1; Skin Corr. 1A; STOT SE 3
(2E)-2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino) acetamide	-	166900-80-7	Repr. 2; Acute Tox. 4; STOT RE 2; Skin Sens. 1
(2E)-3-phenylprop-2-enal	604-377-8	14371-10-9	Skin Sens. 1A
(2R)-2-amino-2-phenylacetamide	420-370-0	6485-67-2	Eye Irrit. 2; Skin Sens. 1
(2R)-butan-2-amine	236-232-6	13250-12-9	Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
(2R, 3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (1R)-10-camphorsulfonate UK-103,449-BV	427-100-0	-	Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
(2R, 3S, 4R, 5R, 7R, 9R, 10R,11S, 12S, 13R)-10-[(4-dimethylamino-3-hydroxy-6-methyltetrahydropyran-2-yl)oxy]-2-ethyl-3,4,12-trihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-6,14-dioxo-1-oxacyclotetradecane	433-820-6	118058-74-5	Eye Irrit. 2
(2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate 4-AA; AOSA; AZETIDONE-KANEKA; GR91990X	408-050-9	76855-69-1	Eye Irrit. 2; Skin Sens. 1
(2R,3S)-N-(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitrobenzenesulfonamide hydrochloride	425-260-6	244634-31-9	STOT RE 2; Eye Dam. 1; Skin Sens. 1
(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one, rotenone	201-501-9	83-79-4	Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
(2RS)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol; mefentrifluconazole	822-682-6	1417782-03-6	Skin Sens. 1
(2S)-5-(benzyloxy)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acid	443-560-5	88784-33-2	Eye Irrit. 2
(2S)-butan-2-amine	208-164-7	513-49-5	Flam. Liq. 2; Acute Tox. 4; Skin Corr. 1A
(2S, 5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide	427-200-4	76646-91-8	Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
(3'-carboxymethyl-5-(2-(3-ethyl-3H-benzothiazol-2-ylidene)-1-methyl-ethylidene)-4,4'-dioxo-2'-thioxo-(2,5')bithiazolidinyliden-3-yl)-acetic acid CIN 10094329; SENSIBILISATOR KF 693 PINA; SENSITIZER KF 693 PINA	422-240-9	166596-68-5	Eye Dam. 1; Skin Sens. 1
(3,3'-Dimethyl(1,1'-biphenyl)-4,4'-diyl)diammonium bis(hydrogen sulphate)	265-294-7	64969-36-4	Carc. 1B; Acute Tox. 4
(3-aminophenyl)pyridin-3-ylmethanone	428-230-0	79568-06-2	STOT RE 2
(3-chloro-2-hydroxypropyl); trimethylammonium chloride ... %	222-048-3	3327-22-8	Carc. 2
(3-chlorophenyl)-(4-methoxy-3-nitrophenyl)methanone T 1569; T001569	423-290-4	66938-41-8	Muta. 2
(3S, 4aS, 8aS)-N-tert-butyldecahydro-3-isoquinolinecarboxamide	420-380-5	136465-81-1	Acute Tox. 4; Eye Dam. 1
(3S, 6R, 9S, 12R, 15S, 18R, 21S,24R)-6,18-dibenzyl-3,9,15,21-tetraisobutyl-4,10,12,16,22,24-hexamethyl-1,7,13,19-tetraoxa-4,10,16,22-tetraazacyclo-tetracosane-2,5,8,11,14,17,20,23-octaone	444-350-6	133413-70-4	Eye Irrit. 2
(3S,4aS,8aS)-2-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-tert-butyldecahydroisoquinoline-3-carboxamide PTH-AA	430-230-0	136522-17-3	Acute Tox. 4
(3β, 5α, 6β)-3-(acetyloxy)-5-bromo-6-hydroxy-androstan-17-one 17-KETOBROMOHYDRINE	419-790-7	4229-69-0	Skin Sens. 1
(4-(1-methylethyl)phenyl)-(4-methylphenyl)iodonium tetrakis(pentafluorophenyl)borate(1-) PHOTOAMORCEUR 22074; RHODORSIL PHOTOINITIATOR 2074; TEPBI	422-960-3	178233-72-2	Acute Tox. 4; STOT RE 2
(4-aminophenyl)-N-methylmethylensulfonamide hydrochloride SULPHONAMIDO-ANILINE	406-010-5	88918-84-7	Eye Dam. 1; Skin Sens. 1
(4-ammonio-m-tolyl)ethyl(2-hydroxyethyl)ammonium sulphate; 4-(N-ethyl-N-2-hydroxyethyl)-2-methylphenylenediamine sulphate	247-162-0	25646-77-9	Acute Tox. 3; STOT RE 2; Skin Sens. 1
(4-ethoxyphenyl)(3-(4-fluoro-3-phenoxyphenyl)propyl)dimethylsilane SILANEOPHAN	405-020-7	105024-66-6	Repr. 1B
(4-hydrazinophenyl)-N-methylmethanesulfonamide hydrochloride SULPHAZINE	406-090-1	81880-96-8	Muta. 2; Acute Tox. 3; STOT RE 1; Skin Sens. 1
(4-phenylbutyl)phosphinic acid	420-450-5	86552-32-1	Carc. 2; Eye Dam. 1
(4aR,8aR)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one	428-690-2	1668-86-6	Acute Tox. 4; Eye Irrit. 2
(4aS-cis-)-6-benzyl-octahydropyrrolo[3.4-b]pyridine	425-930-8	151213-39-7	Skin Corr. 1B; Acute Tox. 4; STOT RE 2
(5-chloro-2-methoxy-4-methyl-3-pyridyl) (4,5,6-trimethoxy-o-tolyl)methanone; pyriofenone	692-456-8	688046-61-9	Carc. 2
(6-(4-hydroxy-3-(2-methoxyphenylazo)-2-sulfonato-7-naphthylamino)-1,3,5-triazin-2,4-diyl)bis[(amino-1-methylethyl)ammonium] formate 2691; CARTASOL BRILLANT SCHARLACH K-2GL KONZ.; CARTASOL BRILLANTSCHARLACH K-2GL FLÜSSIG (ZUBEREITUNG); CARTASOL BRILLANTSCHARLACH K-2GL GRANULAT (ZUBEREITUNG); CARTASOL BRILLIANT SCARLET K-2GL; CARTASOL BRILLIANT SCARLET K-2GL CONC.	402-060-7	108225-03-2	Carc. 1B; Eye Dam. 1
(6R-trans)-1-((7-ammonio-2- carboxylato-8-oxo-5-thia-1- azabicyclo-[4.2.0]oct-2-en-3- yl)methyl)pyridinium iodide	423-260-0	100988-63-4	Muta. 2; Skin Sens. 1
(6β)-6,19-epoxyandrost-4-ene-3,17-dione	433-490-3	6563-83-3	Skin Sens. 1
(9S)-9-amino-9-deoxyerythromycin E.M.A.	406-790-7	26116-56-3	Eye Dam. 1
(benzothiazol-2-ylthio)methyl thiocyanate; TCMTB	244-445-0	21564-17-0	Acute Tox. 2; Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
(benzothiazol-2-ylthio)succinic acid (2-BENZOTHIAZOLYLTHIO)BERNSTEINSÄURE; BTTBS; HALOX 650; IRGACOR 252	401-450-4	95154-01-1	Skin Sens. 1
(C16 or C18-n-alkyl)(C16 or C18-n-alkyl)ammonium 2-((C16 or C18-n-alkyl)(C16 or C18-n-alkyl)carbamoyl)benzenesulphonate OA 8523	402-460-1	-	Skin Irrit. 2; Skin Sens. 1
(E)-(7R,11R)-3,7,11,15-tetramethylhexadec-2-ene-1-ol	616-221-6	7541-49-3	Skin Irrit. 2
(E)-2-butenal; (E)-crotonaldehyde	204-647-1	123-73-9	Flam. Liq. 2; Muta. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
(E)-2-methoxy-4-(prop-1-enyl)phenol	227-678-2	5932-68-3	Skin Sens. 1A
(E)-3,7-dimethyl-2,6-octadienylhexadecanoate HEXAROSE	421-370-3	3681-73-0	Skin Irrit. 2
(E)-3-(2-chlorophenyl)-2-(4-fluorophenyl)propenal DPP	410-980-5	112704-51-5	Eye Irrit. 2; Skin Sens. 1
(E)-3-(4-(4-fluorophenyl)-5-methoxymethyl-2,6-bis(1-methoxymethyl)pyridin-3-yl)prop-2-enal PYRIDYLACROLEIN	426-330-9	177964-68-0	Eye Irrit. 2; Skin Sens. 1
(E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol CP-166,221	428-010-4	82413-20-5	Carc. 2; Repr. 1B; Skin Sens. 1
(E)-3-methyl-5-cyclopentadecen-1-one	429-900-5	101151-17-1	Skin Sens. 1
(E)-but-2-ene	210-855-3	624-64-6	Flam. Gas 1; Press. Gas
(E, Z)-4-chlorophenyl(cyclopropyl)ketone O-(4-nitrophenylmethyl)oxime NCC ETHER	406-100-4	94097-88-8	Skin Sens. 1
(E,E)-3,7,11-trimethyldodeca-1,4,6,10-tetraen-3-ol	423-240-1	125474-34-2	Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
(E-E)-3,3'-(1,4-phenylenedimethylidene)bis(2-oxobornane-10-sulfonic acid) MEXORYL SX; SX 32	410-960-6	92761-26-7	Eye Dam. 1
(ethyl-1,2-ethanediyl)[-2-[[[(2-hydroxyethyl)methylamino]acetyl]-propyl]ω-(nonylphenoxy)poly]oxy-(methyl-1,2-ethanediyl) TFA-4713	418-960-8	-	Skin Corr. 1B; Skin Sens. 1
(ethyl-3-oxobutanoato-O'1,O'3)(2-dimethylaminoethanolato)(1-methoxypropan-2-olato)aluminium(III), dimerised AOC 1020X	402-370-2	149057-70-5	Flam. Liq. 3; Eye Dam. 1
(isodecanoato-O)(isononanoato-O)nickel	284-348-0	84852-36-8	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(isodecanoato-O)(isooctanoato-O)nickel	285-909-2	85166-19-4	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(isononanoato-O)(isooctanoato-O)nickel	287-471-8	85508-46-9	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(isononanoato-O)(neodecanoato-O)nickel	287-592-6	85551-28-6	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(isooctanoato-O)(neodecanoato-O)nickel	284-347-5	84852-35-7	Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
(methylenebis(4,1-phenylenazo(1-(3-(dimethylamino)propyl)-1,2-dihydro-6-hydroxy-4-methyl-2-oxopyridine-5,3-diyl)))-1,1'dipyridinium dichloride dihydrochloride CARTASOL GEEL M-GL CONC.; CARTASOL GELB M-GL FLÜSSIG (ZUBEREITUNG); CARTASOL GELB M-GL KONZ.; CARTASOL YELLOW M-GL CONC.; HM 2580	401-500-5	118658-99-4	Carc. 1B
(N-benzyl-N, N,N-tributyl)ammonium 4-dodecylbenzenesulfonate TICA 118	422-200-0	178277-55-9	Skin Corr. 1B; Acute Tox. 4
(N-benzyl-N-ethyl)amino-3-hydroxyacetophenone hydrochloride ETILEFRONE. HCL	401-840-4	55845-90-4	Eye Dam. 1
(R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratrylisoquinoline hydrochloride R-THP	415-110-8	54417-53-7	Acute Tox. 4
(R)-1-cyclohexa-1,4-dienyl-1-methoxycarbonyl-methylammoniumchloride	444-320-2	-	Acute Tox. 4
(R)-2-(4-hydroxyphenoxy)propanoic acid D-HPPA; HPOPS	407-960-3	94050-90-5	Eye Dam. 1
(R)-2-chloro-N-(2-ethyl-6-methyl-phenyl)-N-(2-methoxy-1-methyl-ethyl)-acetamide (0-20 %)	-	178961-20-1	Skin Sens. 1
(R)-3-[(1-methylpyrrolidin-2-yl)methyl]-5-[2-(phenylsulfonyl)ethenyl]-1H-indole	430-560-5	180637-89-2	Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1
(R)-4-(4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile	430-760-2	219861-18-4	Acute Tox. 4; Skin Sens. 1

Showing 1 - 100 of 4,691 results.

Export search results to:

EU-SAFETY_HEALTH_WORK-PREAMBLE

EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

RELEVANT LEGISLATION

Contact EUCLEF Helpdesk

Last updated 16 April 2024. Database contains 4691 unique substances/entries.

Footer Nav Items