EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

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Last updated 19 April 2024. Database contains 4691 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
heptenophos (ISO); 7-chlorobicyclo(3.2.0)hepta-2,6-dien-6-yl dimethyl phosphate
245-737-0
23560-59-0
Acute Tox. 3
hexabromocyclododecane
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alpha-hexabromocyclododecane EC / List no: 603-801-9 | CAS no: 134237-50-6
beta-hexabromocyclododecane EC / List no: 603-802-4 | CAS no: 134237-51-7
gamma-hexabromocyclododecane EC / List no: 603-804-5 | CAS no: 134237-52-8
1,2,5,6,9,10-hexabromocyclodecane EC / List no: 221-695-9 | CAS no: 3194-55-6
Hexabromocyclododecane EC / List no: 247-148-4 | CAS no: 25637-99-4
247-148-4
25637-99-4
Repr. 2; Lact.
hexahydromethylphthalic anhydride
247-094-1
25550-51-0
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
hexapentyldistannoxane
247-143-7
25637-27-8
Acute Tox. 4
hexyl acrylate
219-698-5
2499-95-8
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
hydroxylamine phosphate
244-077-0
20845-01-6
Expl. 1.1; Carc. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
hydroxyphosphonoacetic acid
DP-3337
405-710-8
23783-26-8
Acute Tox. 4; STOT RE 2; Skin Corr. 1B; Skin Sens. 1
imidazole
206-019-2
288-32-4
Repr. 1B; Acute Tox. 4; Skin Corr. 1C
indium phosphide
244-959-5
22398-80-7
Carc. 1B; Repr. 2; STOT RE 1
iprobenfos(ISO); S-benzyl diisopropyl phosphorothioate
247-449-0
26087-47-8
Acute Tox. 4
isobenzan (ISO); 1,3,4,5,6,7,8,8-octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran
206-045-4
297-78-9
Acute Tox. 1; Acute Tox. 2
isobutyl but-3-enoate
ISOBUTYLVINYL ACETATE; IVA
401-170-2
24342-03-8
Flam. Liq. 3
isofenphos (ISO); O-ethyl O-2-isopropoxycarbonylphenyl-isopropylphosphoramidothioate
246-814-1
25311-71-1
Acute Tox. 3
isooctane
247-861-0
26635-64-3
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
isooctyl acrylate
249-707-8
29590-42-9
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
isoprocarb (ISO); 2-isopropylphenyl N-methylcarbamate
220-114-6
2631-40-5
Acute Tox. 4
lead hexafluorosilicate
247-278-1
25808-74-6
Repr. 1A; Acute Tox. 4; STOT RE 2
lenacil (ISO); 3-cyclohexyl-6,7- dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione
218-499-0
2164-08-1
Carc. 2
leptophos (ISO); O-4-bromo-2,5-dichlorophenyl O-methyl phenylphosphorothioate
244-472-8
21609-90-5
Acute Tox. 3; STOT SE 1; Acute Tox. 4
lithium perfluorooctane sulfonate; lithium heptadecafluorooctanesulfonate
249-644-6
29457-72-5
Carc. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Lact.
lithium potassium sodium N,N''-bis{6-[7-[4-(4-chloro-1,3,5-triazin-2-yl)amino-4-(2-ureidophenylazo)]naphthalene-1,3,6-trisulfonato}-N'-(2-aminoethyl)piperazine
427-850-9
202667-43-4
Skin Sens. 1
m-tolylidene diisocyanate; toluene-diisocyanate
247-722-4
26471-62-5
Carc. 2; Acute Tox. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
malachite green oxalate
219-441-7
2437-29-8
Repr. 2; Acute Tox. 4; Eye Dam. 1
MCPA-thioethyl (ISO); S-ethyl (4-chloro-2-methylphenoxy)ethanethioate; S-ethyl 4-chloro-o-tolyloxythioacetate
246-831-4
25319-90-8
Acute Tox. 4
mecarbam (ISO); N-ethoxycarbonyl-N-methylcarbamoylmethyl O, O-diethyl phosphorodithioate
219-993-9
2595-54-2
Acute Tox. 3
medinoterb acetate (ISO); 6-tert-butyl-3-methyl-2,4-dinitrophenyl acetate
219-634-6
2487-01-6
Acute Tox. 3; Acute Tox. 4
mepiquat chloride (ISO); 1,1-dimethylpiperidinium chloride
246-147-6
24307-26-4
Acute Tox. 4; Acute Tox. 3
mercaptodimethur (ISO); methiocarb (ISO); 3,5-dimethyl-4-methylthiophenyl N-methylcarbamate
217-991-2
2032-65-7
Acute Tox. 3
methyl (S)-(-)-lactate
248-704-9
27871-49-4
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl (±)-lactate;methyl lactate
208-930-0
2155-30-8;547-64-8
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl (±)-lactate;methyl lactate
208-930-0
2155-30-8;547-64-8
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
methyl 2,5-dichlorobenzoate
220-815-7
2905-69-3
Acute Tox. 4; STOT SE 3
methyl N-(isopropoxycarbonyl)-L-valyl-(3RS)-3-(4-chlorophenyl)-β-alaninate; valifenalate
608-192-3
283159-90-0
Carc. 2
methyl-phenylene diamine
246-910-3
25376-45-8
Carc. 1B; Muta. 2; Repr. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; Skin Sens. 1
methylenediphenyl diisocyanate
247-714-0
26447-40-5
Carc. 2; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
methylethylketone peroxide trimer
429-320-2
24748-23-0
Org. Perox. B; Asp. Tox. 1; Skin Irrit. 2; Skin Sens. 1
metribuzin (ISO); 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one; 4-amino-4,5-dihydro-6-(1,1-dimethylethyl)-3-methylthio-1,2,4-triazin-5-one
244-209-7
21087-64-9
Acute Tox. 4; STOT RE 2
molinate (ISO);S-ethyl 1-perhydroazepinecarbothioate; S-ethyl perhydroazepine-1-carbothioate
218-661-0
2212-67-1
Carc. 2; Repr. 2; Acute Tox. 4; STOT RE 2; Skin Sens. 1
monosodium 3-cyano-5-fluoro-6-hydroxypyridine-2-olate
429-570-2
213990-58-0
Skin Sens. 1
morfamquat sulfate
-
29873-36-7
Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
muscalure; cis-tricos-9-ene
248-505-7
27519-02-4
Skin Sens. 1B
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide
435-860-1
214417-91-1
Skin Sens. 1
N, N',N''-tris(2-methyl-2,3-epoxypropyl)-perhydro-2,4,6-oxo-1,3,5-triazine
435-010-8
26157-73-3
Muta. 2
N, N-(dimethylamino)thioacetamide hydrochloride
435-470-1
27366-72-9
Repr. 1B
N, N-bis(trimethylsilyl)aminopropylmethyldiethoxysilane
445-890-5
201290-01-9
Acute Tox. 4; Skin Sens. 1
N,N'-dimethylbenzidine
-
2810-74-4
Acute Tox. 4
N,N-dimethylbenzene-1,3-diamine
220-623-3
2836-04-6
Acute Tox. 3
N-(2-(4-amino-N-ethyl-m-toluidino)ethyl)methanesulphonamide sesquisulphate; 4-(N-ethyl-N-2-methanesulphonylaminoethyl)-2-methylphenylenediamine sesquisulphate monohydrate
247-161-5
25646-71-3
Acute Tox. 4; Skin Sens. 1
N-(n-octyl)-2-pyrrolidone
NOP; SURFADONE LP-100 SURFACTANT
403-700-8
2687-94-7
Skin Corr. 1B
N-amidino-N-methylglycine-2-oxopropionate
429-120-5
208535-04-0
Eye Dam. 1
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