EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

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Last updated 23 April 2024. Database contains 4691 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
d-carvone; (5S)-2-methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-one
218-827-2
2244-16-8
Skin Sens. 1
di(benzothiazol-2-yl) disulphide
204-424-9
120-78-5
Skin Sens. 1
diethyl{4-[1,5,5-tris(4-diethylaminophenyl)penta-2,4-dienylidene]cyclohexa-2,5-dienylidene}ammonium butyltriphenylborate
IRB
418-070-1
141714-54-7
Skin Sens. 1
dilithium 6-acetamido-4-hydroxy-3-(4-((2-sulphonatooxy)ethylsulphonyl) phenylazo)naphthalene-2-sulphonate
REACTIVE ORANGE F-64 258 FW
401-010-1
106027-83-2
Skin Sens. 1
dimethyl (3-methyl-4-(5-nitro-3-ethoxycarbonyl-2-thienyl)azo)phenylnitrilodipropionate
C.I. DISPERSE BLUE 356
400-460-6
118578-14-6
Skin Sens. 1
dimethyl[2S, 2S']-6,6,6'6'-tetramethoxy-2,2'-[N, N'-bis(trifluoracetyl)-S, S'-bi(L-homocysteinyl) diimino]dihexanoate
432-860-1
255387-46-3
Skin Sens. 1
diphenyl(4-phenylthiophenyl)sulfonium hexafluoroantimonate
680-227-5
71449-78-0
Skin Sens. 1
disodium 2-[[4-(2-chloroethylsulfonyl)phenyl]-[(2-hydroxy-5-sulfo-3-[3-[2-(2-(sulfooxy)ethylsulfonyl)ethylazo]-4-sulfobenzoato(3-)cuprate(1-)
PRODUKT 1096
414-230-8
-
Skin Sens. 1
disodium 6-((4-chloro-6-(N-methyl)-2-toluidino)-1,3,5-triazin-2-ylamino)-1-hydroxy-2-(4-methoxy-2-sulphonatophenylazo)naphthalene-3-sulphonate
DRIMAREN SCHARLACH X-GA 979; DRIMAREN SCHARLAKEN X-GA; DRIMAREN SCHARLAKEN X-GA 979; DRIMARENE SCARLET X-2 GN; ECARLATE DRIMARENE X-2GN; ECARLATE DRIMARENE X-GA 979; ECARLATE X-GA 979; SCARLET X-GA 979
400-380-1
86393-35-3
Skin Sens. 1
disodium 7-(4,6-dichloro-1,3,5-triazin-2-ylamino)-4-hydroxy-3-(4-(2-(sulfonatooxy)ethylsulfonyl)phenylazo) naphthalene-2-sulfonate
EVERZOL ORANGE GR; ORANGE HF-SNK; REAKTIV ORANGE FD 19969 FW
404-600-7
129009-88-7
Skin Sens. 1
disodium S,S-hexane-1,6-diyldi(thiosulphate) dihydrate
DURALINK (R) HTS; ERP-390
401-320-7
5719-73-3
Skin Sens. 1
dodecyl 3,4,5-trihydroxybenzoate
214-620-6
1166-52-5
Skin Sens. 1
dodecyl 3-amino-4-chlorobenzoate
428-020-9
6195-20-6
Skin Sens. 1
ethidimuron (ISO); 1-(5-ethylsulphonyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea
250-010-6
30043-49-3
Skin Sens. 1
ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate
429-680-0
122665-86-5
Skin Sens. 1
ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
DM-8
405-880-3
100501-62-0
Skin Sens. 1
ethyl 2-(4-phenoxyphenyl)lactate
429-220-9
132584-17-9
Skin Sens. 1
ethyl 2-[4-[(6-chlorobenzoxazol-2-yl)oxy]phenoxy]propionate; fenoxaprop-ethyl
266-362-9
66441-23-4
Skin Sens. 1
ethyl 6,8-dichlorooctanoate
6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
435-080-1
1070-64-0
Skin Sens. 1
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate
422-360-1
100491-29-0
Skin Sens. 1
ethyl trans-3-dimethylaminoacrylate
BETA-DAASE; BETA-DIMETHYLAMIMO ACRYLIC ACID ETHYLESTER
402-650-4
1117-37-9
Skin Sens. 1
formaldehyde, reaction products with butylphenol
294-145-9
91673-30-2
Skin Sens. 1
geraniol; (2E)-3,7-dimethylocta-2,6-dien-1-ol
203-377-1
106-24-1
Skin Sens. 1
hexasodium 7-(4-(4-(4-(2,5-disulphonatoanilino)-6-fluoro-1,3,5-triazin-2-ylamino)-2-methylphenylazo)-7-sulphonatonaphthylazo)naphthalene-1,3,5-trisulphonate
BRUN REACTIF 45; BRUNO REATTIVO 45; C.I. REACTIVE BROWN 45; CIBACROM BROWN 1347; CIBACRON BROWN 1347; REACTIVE BRAUN 45
401-650-1
85665-96-9
Skin Sens. 1
hydrogen sodium N-carboxylatoethyl-N-octadec-9-enylmaleamate
2-BUTANEDIOIC ACID, MONOAMIDE WITH N-(9-OCTADECENYL)-3-AMINO
402-970-4
148292-42-6
Skin Sens. 1
l-carvone; (5R)-2-methyl-5- (prop-1-en-2-yl)cyclohex-2-en- 1-one
229-352-5
6485-40-1
Skin Sens. 1
lithium potassium sodium N,N''-bis{6-[7-[4-(4-chloro-1,3,5-triazin-2-yl)amino-4-(2-ureidophenylazo)]naphthalene-1,3,6-trisulfonato}-N'-(2-aminoethyl)piperazine
427-850-9
202667-43-4
Skin Sens. 1
lithium sodium hydrogen 4-amino-6-(5-(5-chloro-2,6-difluoropyrimidin-4-ylamino)-2-sulphonatophenylazo)-5-hydroxy-3-(4-(2-(sulphonatooxy)ethylsulphonyl)phenylazo)naphthalene-2,7-disulphonate
REACTIVE BLUE FC 05 717
401-560-2
108624-00-6
Skin Sens. 1
lufenuron (ISO); N-[2,5-dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)-phenyl-aminocarbonyl]-2,6-difluorobenzamide
CGA 184699
410-690-9
103055-07-8
Skin Sens. 1
Main component: acetoacetic acid anilide/3-amino-1-hydroxybenzene (ATAN-MAP): trisodium {6-[(2 or 3 or 4)-amino-(4 or 5 or 6)-hydroxyphenylazo]-5'-(phenylsulfamoyl)-3-sulfonatonaphthalene-2-azobenzene-1,2'-diolato}-{6''-[1-(phenylcarbamoyl)ethylazo]-5'-(phenylsulfamoyl)-3-sulfonatonaphthalene-2''-azobenzene-1'',2'''-diolato}chromate (III); by-product 1: acetoacetic acid anilide/acetoacetic acid anilide (ATAN-ATAN): trisodium bis{6-[1-(phenylcarbamoyl)ethylazo]-5'''-(phenylsulfonyl)-3''-sulfonatonaphthalene-2-azobenzene-1,2'-diolato}chromate (III); by-product 2: 3-amino-1-hydroxybenzene/3-amino-1-hydroxybenzene (MAP-MAP): trisodium bis{6-[(2 or 3 or 4)-amino-(4 or 5 or 6)-hydroxyphenylazo]-5'-(phenylsulfamoyl)-3-sulfonatonaphthalene-2-azobenzene-1,2'-diolato}chromate (III)
BLACK JR 578
419-230-1
-
Skin Sens. 1
methyl (9-acetoxy-3,8,10-triethyl-7,8,10-trimethyl-1,5-dioxa-9-aza-spiro[5.5]undec-3-yl)octadecanoate
445-990-9
376588-17-9
Skin Sens. 1
methyl 2-(2-nitrobenzylidene)acetoacetate
2-NITROBENZYLIDENE METHYL ESTER; BAY O 2787
400-650-9
39562-27-1
Skin Sens. 1
methyl 2-(3-nitrobenzylidene)acetoacetate
BM
405-270-7
39562-17-9
Skin Sens. 1
methyl 2-(acetylamino)-3-chloropropionate
442-860-3
87333-22-0
Skin Sens. 1
methyl 2-[4-(2-chloro-4-nitrophenylazo)-3-(1-oxopropyl)amino]phenylaminopropionate
DISPERSE RED CLA 282
416-240-8
155522-12-6
Skin Sens. 1
methyl 2-aminosulfonyl-6-(trifluoromethyl)pyridine-3-c arboxylate
JE 127
421-220-7
144740-59-0
Skin Sens. 1
methyl 3-sulphamoyl-2-thenoate
A5546
402-050-2
59337-93-8
Skin Sens. 1
methyl N-[3-acetylamino)-4-(2-cyano-4-nitrophenylazo)phenyl]-N-[(1-methoxy)acetyl]glycinate
FAT 40'489
413-040-2
149850-30-6
Skin Sens. 1
methyl α-((4,6-dimethoxypyrimidin-2-yl)ureidosulphonyl)-o-toluate
F5384
401-340-6
83055-99-6
Skin Sens. 1
methyl-3-methoxyacrylate
BETA-METHOXYACRYLSÄURE METHYLESTER
412-900-4
5788-17-0
Skin Sens. 1
monosodium 3-cyano-5-fluoro-6-hydroxypyridine-2-olate
429-570-2
213990-58-0
Skin Sens. 1
N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide
435-860-1
214417-91-1
Skin Sens. 1
N, N''-(methylenedi-4,1-phenylene)bis[N'-(4-methylphenyl)urea]
429-380-1
133336-92-2
Skin Sens. 1
N, N'-diphenyl-p-phenylenediamine; N, N'-diphenyl-1,4-benzenediamine
200-806-4
74-31-7
Skin Sens. 1
N, N-bis(2-(p-toluenesulfonyloxy)ethyl)-p-toluenesulfonamide
DIETHANOLAMIN-TRITOSYLAT
412-920-3
16695-22-0
Skin Sens. 1
N,N,N,N-tetrakis(4,6-bis(butyl- (N-methyl-2,2,6,6-tetramethyl piperidin-4-yl)amino)triazin-2- yl)-4,7-diazadecane-1,10- diamine
CHIMASSORB 119; LOWILITE 19
401-990-0
106990-43-6
Skin Sens. 1
N-(2-(6-ethyl-7-(4-methylphenoxy)-1H-pyrazolo[1,5-b][1,2,4]triazol-2-yl)propyl)-2-octadecyloxybenzamide
UM-229
407-070-5
142859-67-4
Skin Sens. 1
N-(4-(3-(4-cyanophenyl)ureido)-3-hydroxyphenyl)-2-(2,4-di-tert-pentylphenoxy)octanamide
UC-129
403-790-9
108673-51-4
Skin Sens. 1
N-(5-chloro-3-((4-(diethylamino)-2-methylphenyl)imino-4-methyl-6-oxo-1,4-cyclohexadien-1-yl)benzamide
TSD-40
413-200-1
129604-78-0
Skin Sens. 1
N-benzyl-N-ethyl-(4-(5-nitro-benzo[c]isothiazol-3-ylazo)phenyl)amine
425-300-2
186450-73-7
Skin Sens. 1
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