EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

Last updated 16 April 2024. Database contains 4691 unique substances/entries.

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Showing 1 - 50 of 4,691 results.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)
proteases with the exception of those specified elsewhere in this Annex show/hide Proteinase, rhizopus acid EC / List no: 812-486-9 \| CAS no: 9074-09-3 Bacteria, complex with amylase and proteinase EC / List no: - \| CAS no: 68920-42-3 Myxobacteralphalyticproteinase EC / List no: - \| CAS no: 12585-31-8 Proteinase, microbial acid EC / List no: 256-862-5 \| CAS no: 50936-52-2 Proteinase, Aspergillus melleus, semialkaline EC / List no: - \| CAS no: 76106-83-7 Proteinase, Bothrops atrox serine EC / List no: 232-918-4 \| CAS no: 9039-61-6 Proteinase, Myxobacter α-lytic EC / List no: 253-448-6 \| CAS no: 37288-76-9 Proteinase, Aspergillus acid EC / List no: 232-796-2 \| CAS no: 9025-49-4 Proteinase, aspartic EC / List no: 278-856-1 \| CAS no: 78169-47-8 Thrombin EC / List no: 232-648-7 \| CAS no: 9002-04-4 Proteinase, Endothia aspartic EC / List no: 253-395-9 \| CAS no: 37205-60-0 Proteinase, Bacillus alkaline EC / List no: 232-972-9 \| CAS no: 9073-77-2 Amylase, mixed with proteinase, Bacillus thuringiensis-fermented EC / List no: - \| CAS no: 68909-36-4 Proteinase, Tritirachium album serine EC / List no: 254-457-8 \| CAS no: 39450-01-6 Proteinase, serine EC / List no: 253-431-3 \| CAS no: 37259-58-8 Proteinase, Aspergillus neutral EC / List no: 278-588-5 \| CAS no: 77000-13-6 Bacillus megaterium protease fermentation product EC / List no: - \| CAS no: 68909-17-1 Proteinase, microbial alkaline EC / List no: 256-863-0 \| CAS no: 50936-53-3 Proteinase, Aspergillus parasiticus neutral EC / List no: 254-418-5 \| CAS no: 39335-09-6 Proteinase, Staphylococcus aureus serine EC / List no: 259-611-8 \| CAS no: 55354-32-0 Proteinase, Bacillus subtilis metallo- EC / List no: 232-991-2 \| CAS no: 9080-56-2 Proteinase, Bacillus alcalophilus serine EC / List no: 306-090-0 \| CAS no: 95979-76-3 Proteinase, submandibular gland serine, A EC / List no: 279-893-6 \| CAS no: 82047-85-6 Proteinase, Aspergillus niger neutral EC / List no: 254-422-7 \| CAS no: 39346-39-9 Proteinase, serine (Tritirachium album) EC / List no: 686-165-5 \| CAS no: 102925-54-2 Proteinase, Serratia extracellular EC / List no: 253-457-5 \| CAS no: 37312-62-2 Proteinase, Myxobacter AL-1, II EC / List no: 276-716-4 \| CAS no: 72561-05-8 Proteinase, oryzin EC / List no: 232-992-8 \| CAS no: 9081-30-5 Aspergillin M EC / List no: - \| CAS no: 42615-60-1 Proteinase, Aspergillus alkaline EC / List no: 232-977-6 \| CAS no: 9074-07-1 Proteinase, Streptomyces griseus EC / List no: 232-909-5 \| CAS no: 9036-06-0 Proteinase, Agkistrodon serine EC / List no: 232-933-6 \| CAS no: 9046-56-4 Proteinase, microbial neutral EC / List no: 232-966-6 \| CAS no: 9068-59-1 Proteinase, Bacillus licheniformis serine EC / List no: 279-361-3 \| CAS no: 79986-26-8 Proteinase, Bacillus subtilis EC / List no: 257-520-8 \| CAS no: 51931-23-8 Proteinase, Aspergillus oryzae neutral EC / List no: 232-990-7 \| CAS no: 9080-55-1 Proteinase, Bacillus polymyxa neutral EC / List no: 255-914-4 \| CAS no: 42613-33-2 Amylase, mixture with proteinase EC / List no: 685-079-5 \| CAS no: 9001-11-0 Proteinase, Mucor aspartic EC / List no: 232-975-5 \| CAS no: 9073-79-4 Amylase, mixed with proteinase, Bacillus cereus-fermented EC / List no: - \| CAS no: 68909-35-3 Proteinase, Bacillus subtilis serine EC / List no: 266-557-9 \| CAS no: 67051-83-6 Proteinase, Bacillus neutral EC / List no: 278-547-1 \| CAS no: 76774-43-1 Proteinase, pancreatic EC / List no: 232-626-7 \| CAS no: 9001-72-3 Proteinase, Bacillus subtilis, sutilain EC / List no: 235-390-3 \| CAS no: 12211-28-8 Proteinase, bacterial E 30 serine EC / List no: - \| CAS no: 39369-34-1	934-013-6	39450-01-6	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
(2RS)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol; mefentrifluconazole	822-682-6	1417782-03-6	Skin Sens. 1
N-methoxy-N-[1-methyl-2-(2,4,6-trichlorophenyl)-ethyl]-3-(difluoromethyl)- 1-methylpyrazole-4-carboxamide; pydiflumetofen	817-852-1	1228284-64-7	Carc. 2; Repr. 2
(RS)-4-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; medetomidine	811-718-6	86347-14-0	Acute Tox. 2; STOT SE 3; STOT SE 1; STOT RE 1
N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide; isoflucypram	811-438-4	1255734-28-1	Repr. 2; Acute Tox. 4; Skin Sens. 1B
sulfoxaflor (ISO); [methyl(oxo) {1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-λ6-sulfanylidene]cyanamide	807-366-8	946578-00-3	Acute Tox. 4
4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one; flupyradifurone	804-373-8	951659-40-8	Acute Tox. 4; STOT RE 2
metaflumizone (ISO); (E)-2-[2-(4-cyanophenyl)-1-(a,a,a -trifluoro-m-tolyl) ethylidene]-[4-(trifluoro-methoxy)phenyl]carbani-lohydrazide [2]	701-454-9	852403-68-0	Repr. 2; Lact.; STOT RE 2
6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid, sodium and tris(2-hydroxyethyl)ammonium salts	701-271-4	-	Repr. 1B; Eye Irrit. 2
(RS)-1-{1-ethyl-4-[4-mesyl-3-(2-methoxyethoxy)-o-toluoyl]pyrazol-5-yloxy} ethyl methyl carbonate; tolpyralate	701-225-3	1101132-67-5	Carc. 2; Repr. 2; STOT RE 2
6-[C12-18-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid	701-162-1	-	Repr. 1B
6-[(C10-C13)-alkyl-(branched, unsaturated)-2,5-dioxopyrrolidin-1-yl]hexanoic acid	701-118-1	2156592-54-8	Repr. 1B; Eye Irrit. 2
phenol, 3-dodecyl-, branched	701-107-1	1801269-77-1	Repr. 1B; Skin Corr. 1C; Eye Dam. 1
phenol, 2-dodecyl-, branched	701-105-0	1801269-80-6	Repr. 1B; Skin Corr. 1C; Eye Dam. 1
2-methyl-1,2-benzothiazol-3(2H)-one; [MBIT]	695-989-4	2527-66-4	Acute Tox. 4; Acute Tox. 3; Skin Corr. 1C; Eye Dam. 1; Skin Sens. 1A
(5-chloro-2-methoxy-4-methyl-3-pyridyl) (4,5,6-trimethoxy-o-tolyl)methanone; pyriofenone	692-456-8	688046-61-9	Carc. 2
benzovindiflupyr (ISO); N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	691-719-4	1072957-71-1	Acute Tox. 3
N-{2-[[1,1'-bi (cyclopropyl)]-2-yl] phenyl}-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide; sedaxane	688-331-2	874967-67-6	Carc. 2
di-L-para-menthene	686-814-2	34363-01-4	Skin Irrit. 2; Skin Sens. 1
acetamiprid (ISO); (1E)-N-[(6-chloropyridin-3-yl)methyl]-N’-cyano-N-methylethanimidamide; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine	682-791-8	160430-64-8	Repr. 2; Acute Tox. 3
tetracopper hexahydroxide sulphate hydrate	682-362-5	12527-76-3	Acute Tox. 4
trinexapac-ethyl (ISO); ethyl 4-[cyclopropyl (hydroxy) methylene]-3,5-dioxocyclohexanecarboxylate	680-302-2	95266-40-3	STOT RE 2; Skin Sens. 1B
diphenyl(4-phenylthiophenyl)sulfonium hexafluoroantimonate	680-227-5	71449-78-0	Skin Sens. 1
amisulbrom (ISO); 3-(3-bromo-6-fluoro-2-methylindol-1-ylsulfonyl)-N,N-dimethyl-1H-1,2,4-triazole-1-sulfonamide	672-776-4	348635-87-0	Carc. 2; Eye Irrit. 2
cyflumetofen (ISO); 2-methoxyethyl (RS)-2-(4-tert-butylphenyl)-2-cyano-3-oxo-3-(α,α,α-trifluoro-o-tolyl)propionate	642-974-5	400882-07-7	Carc. 2; Skin Sens. 1A
hydroxyisohexyl 3-cyclohexene carboxaldehyde (INCI); reaction mass of 4-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde and 3-(4-hydroxy-4-methylpentyl)cyclohex-3-ene-1-carbaldehyde	641-410-5	130066-44-3	Skin Sens. 1A
phenol, 4-dodecyl-, branched	640-104-9	210555-94-5	Repr. 1B; Skin Corr. 1C; Eye Dam. 1
α-hydroxypoly(methyl-(3-(2,2,6,6-tetramethylpiperidin-4-yloxy)propyl)siloxane)	639-478-6	182635-99-0	Acute Tox. 4; Skin Corr. 1B
pinoxaden (ISO); 8-(2,6-diethyl-4-methylphenyl)-7-oxo-1,2,4,5-tetrahydro-7H-pyrazolo[1,2-d][1,4,5]oxadiazepin-9-yl 2,2-dimethylpropanoate	635-361-9	243973-20-8	Repr. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Sens. 1A
Reaction mass of 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9RS)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide and 3-(difluoromethyl)-1-methyl-N-[(1RS,4SR,9SR)-1,2,3,4-tetrahydro-9-isopropyl-1,4-methanonaphthalen-5-yl]pyrazole-4-carboxamide [≥ 78 % syn isomers ≤ 15 % anti isomers relative content]; isopyrazam	632-619-2	881685-58-1	Carc. 2; Repr. 1B; Skin Sens. 1B
methacrifos (ISO); methyl (E)-3-[(dimethoxyphosphinothioyl)oxy]methacrylate	630-448-8	62610-77-9	Acute Tox. 4; Skin Sens. 1
4-nitrosomorpholine	627-564-6	59-89-2	Carc. 1B; Muta. 2; STOT RE 1
3-bromo-2,2-bis(bromomethyl)propan1-ol	622-370-8	1522-92-5	Carc. 1B; Muta. 2
erionite	620-440-2	12510-42-8	Carc. 1A
diclobutrazole (ISO);(R, R)-(±)-β-[(2,4-dichlorop henyl)methyl]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; (2RS, 3RS)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2- (1H—1,2,4-triazol-1yl)pentan-3-ol	620-436-0	75736-33-3	Eye Irrit. 2
propylenethiourea	620-432-9	2122-19-2	Repr. 2; Acute Tox. 4
guazatine (ISO)	620-427-1	108173-90-6	Acute Tox. 2; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
azafenidin (ISO); 2-(2,4-dichloro-5-prop-2-ynyloxyphenyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyridine-3(2H)-one	620-425-0	68049-83-2	Repr. 1B; STOT RE 2
dinosam (ISO); 2-(1-methylbutyl)-4,6-dinitrophenol	620-422-4	4097-36-3	Acute Tox. 3
2,4,6-trinitroanisole	620-419-8	606-35-9	Expl. 1.1; Acute Tox. 4
8,9-dinorborn-5-ene-2,3-dicarboxylic anhydride	620-411-4	123748-85-6	Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
kelevan (ISO); ethyl 5-(perchloro-5-hydroxypentacyclo[5,3,0,02,6,03,9,04,8]decan-5-yl)-4-oxopentanoate; ethyl 5-(1,2,3,5,6,7,8,9,10,10-decachloro-4-hydroxypentacyclo(5,2,1,02,6,03,9,05,8)dec-4-yl)-4-oxovalerate	620-410-9	4234-79-1	Acute Tox. 3; Acute Tox. 4
dichloroacetylene	620-404-6	7572-29-4	Unst. Expl.; Carc. 2; STOT RE 2
basic phenylmercury nitrate	620-403-0	8003-05-2	Acute Tox. 3; STOT RE 1; Skin Corr. 1B
lithium nickel dioxide	620-400-4	12031-65-1	Carc. 1A; STOT RE 1; Skin Sens. 1
cobalt nickel oxide	620-395-9	12737-30-3	Carc. 1A; STOT RE 1; Skin Sens. 1
dimethyl 4-(methylthio)phenyl phosphate	620-379-1	3254-63-5	Acute Tox. 1; Acute Tox. 2
demeton	620-378-6	8065-48-3	Acute Tox. 1; Acute Tox. 2
cyanofenphos (ISO); O-4-cyanophenyl O-ethyl phenylphosphonothioate	620-377-0	13067-93-1	Acute Tox. 3; STOT SE 1; Acute Tox. 4; Eye Irrit. 2
S-[2-(ethylsulphinyl)ethyl] O,O-dimethyl phosphorodithioate	620-370-2	2703-37-9	Acute Tox. 2; Acute Tox. 1

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EU-SAFETY_HEALTH_WORK-PREAMBLE

EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

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Last updated 16 April 2024. Database contains 4691 unique substances/entries.

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