EU-SAFETY_HEALTH_WORK-PREAMBLE

Safety and Health of Workers at Work Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 89/391/EEC, 29 June 1989, amended by Regulation 1137/2008/EC, 21 November 2008 (Table 3/Annex VI, CLP; Annex III, 2000/54/EC)

This list contains a non-exhaustive inventory of substances that fall within the scope of the European Union's definition of hazardous chemical and biological substances, as provided on: (1) Table 3 of Annex VI to the CLP Regulation 1272/2008/EC; and (2) Annex III of Directive 2000/54/EC (Biological Agents). The EU's Occupational Safety and Health (OSH) Framework Directive 89/391/EEC applies to risks arising from chemical, physical and biological agents at the workplace.

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Last updated 18 April 2024. Database contains 4691 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
chlormequat chloride (ISO); 2-chloroethyltrimethylammonium chloride
213-666-4
999-81-5
Acute Tox. 4
2-hydroxypropylacrylate
213-663-8
999-61-1
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
2,4-dichloro-3-ethyl-6-nitrophenol
2,4-DICHLORO-3-ETHYL-6-NITROPHENOL
420-740-1
99817-36-4
Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
bromobenzylbromotoluene, reaction mass of isomers
DBBT
402-210-1
99688-47-8
STOT RE 2; Skin Sens. 1
2-(2-hydroxy-3,5-dinitroanilino)ethanol
PIKRAMINROT
412-520-9
99610-72-7
Flam. Sol. 2; Repr. 2; Acute Tox. 4
ethyl 2-ethoxy-4-carboxymethylbenzoate
ECPA
427-630-2
99469-99-5
Eye Dam. 1
chloro-1-ethylcyclohexyl carbonate
444-950-8
99464-83-2
Muta. 2; Skin Sens. 1
2-methoxy-2-methylbutane; tert-amyl methyl ether
213-611-4
994-05-8
Flam. Liq. 2; Acute Tox. 4; STOT SE 3
trichloromethylstannane
213-608-8
993-16-8
Repr. 2
(±)-[(R*,R*) and (R*,S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran
T001446
419-600-2
99199-90-3
Skin Sens. 1
clethodim (ISO); (5RS)-2-{(1EZ)-1-[(2E)-3-chloroallyloxyimino]propyl}-5-[(2RS)-2-(ethylthio)propyl]-3-hydroxycyclohex-2-en-1-one
619-396-7
99129-21-2
Acute Tox. 4; Skin Sens. 1
sulcotrione (ISO); 2-[2-chloro-4-(methylsulfonyl)benzoyl]cyclohexane-1,3-dione
619-394-6
99105-77-8
Repr. 2; STOT RE 2; Skin Sens. 1A
norbormide (ISO); 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)bicycle [2.2.1] hept-5-ene-2,3-dicarboximide
213-589-6
991-42-4
Acute Tox. 4
4-nitrotoluene
202-808-0
99-99-0
Acute Tox. 3; STOT RE 2
4-amino-N,N-dimethylaniline; 3-amino-N,N'-dimethylaniline
202-807-5
99-98-9
Acute Tox. 3
N,N-dimethyl-p-toluidine
202-805-4
99-97-8
Carc. 1B; Acute Tox. 4; Acute Tox. 3; STOT RE 2
1-isopropyl-4-methylbenzene; p-cymene
202-796-7
99-87-6
Flam. Liq. 3; Acute Tox. 3; Asp. Tox. 1
p-mentha-1,3-diene; 1-isopropyl-4-methylcyclohexa-1,3-diene; alpha-terpinene
202-795-1
99-86-5
Flam. Liq. 3; Acute Tox. 4; Skin Sens. 1; Asp. Tox. 1
1,3-dinitrobenzene
202-776-8
99-65-0
Acute Tox. 2; Acute Tox. 1; STOT RE 2
5-nitro-o-toluidine
202-765-8
99-55-8
Carc. 2; Acute Tox. 3
carvone (ISO); 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
202-759-5
99-49-0
Skin Sens. 1
1,3,5-trinitrobenzene
202-752-7
99-35-4
Expl. 1.1; Acute Tox. 2; Acute Tox. 1; STOT RE 2
m-nitroaniline
202-729-1
99-09-2
Acute Tox. 3; STOT RE 2
9-[2-(ethoxycarbonyl) phenyl]-3,6-bis(ethylamino)–2,7-dimethylxanthylium chloride; Basic Red 1
213-584-9
989-38-8
Acute Tox. 3; Eye Dam. 1; Skin Sens. 1
fosthiazate (ISO); (RS)-S-sec-butyl-O-ethyl-2-oxo-1,3-thiazolidin-3-ylphosphonothioate
619-377-3
98886-44-3
Acute Tox. 3; Acute Tox. 4; Skin Sens. 1
2-[[4[[4,6-bis[[3-(diethylamino)propyl]amino]-1,3,5-triazine-2-yl]amino]phenyl]azo]-N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutanamide
KAYACEL YELLOW CG; NO.466 BZN
407-680-1
98809-11-1
Eye Dam. 1; Skin Sens. 1
reaction mass of: (2R, 3R)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate; (2S, 3S)-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropylammonium methanesulfonate
425-530-3
98769-75-6
Acute Tox. 4; Eye Dam. 1
1-(2-chlorophenyl)-1,2-dihydro-5H-tetrazol-5-one
426-110-2
98377-35-6
Skin Sens. 1
Residues, steam cracked, thermally treated; Heavy Fuel oil [A complex combination of hydrocarbons obtained by the treatment and distillation of raw steam-cracked naphtha. It consists predominantly of unsaturated hydrocarbons boiling in the range above approximately 180°C (356°F).]
A complex combination of hydrocarbons obtained by the treatment and distillation of raw steam-cracked naphtha. It consists predominantly of unsaturated hydrocarbons boiling in the range above approximately 180°C (356°F).
308-733-0
98219-64-8
Carc. 1B
Naphtha (petroleum), light steam-cracked, thermally treated; Low boiling point naphtha -unspecified [A complex combination of hydrocarbons obtained by the treatment and distillation of light steam-cracked petroleum naphtha. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C5 through C6 and boiling in the range of approximately 35 o C to 80 o C (95 °F to 176 °F).]
A complex combination of hydrocarbons obtained by the treatment and distillation of light steam-cracked petroleum naphtha. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C5 through C6 and boiling in the range of approximately 35°C to 80°C (95°F to 176°F).
308-714-7
98219-47-7
Carc. 1B; Muta. 1B; Asp. Tox. 1
Naphtha (petroleum), light steam-cracked, debenzenized, thermally treated; Low boiling point naphtha -unspecified [A complex combination of hydrocarbons obtained by the treatment and distillation of debenzenized light steam-cracked petroleum naphtha. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 95 °C to 200°C (203°F to 392°F).]
A complex combination of hydrocarbons obtained by the treatment and distillation of debenzenized light steam-cracked petroleum naphtha. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 95°C to 200°C (203°F to 392°F).
308-713-1
98219-46-6
Carc. 1B; Muta. 1B; Asp. Tox. 1
5(or 6)-tert-butyl-2'-chloro-6'-ethylamino-3',7'-dimethylspiro(isobenzofuran-1(1H),9'-xanthene)-3-one
R-GELB 2454
400-680-2
98181-47-6
Acute Tox. 4
reaction mass of: trisodium 4-benzoylamino-6-(6-ethenesulfonyl-1-sulfato-naphthalen-2-ylazo)-5-hydroxynaphthalene-2,7-disulfonate; 5-(benzoylamino)-4-hydroxy-3-((1-sulfo-6-((2-(sulfooxy)ethyl)sulfonyl)-2-naphthyl)azo)naphthalene-2,7-disulfonic acid sodium salt; 5-(benzoylamino)-4-hydroxy-3-((1-sulfo-6-((2-(sulfooxy)ethyl)sulfonyl)-2-naphthyl)azo)naphthalene-2,7-disulfonic acid
REACTIVE RED 180 (HYDROLYSED)
423-200-3
98114-32-0
Eye Dam. 1; Skin Sens. 1
nitrobenzene
202-716-0
98-95-3
Carc. 2; Repr. 1B; Acute Tox. 3; STOT RE 1
benzoyl chloride
202-710-8
98-88-4
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
α, α-dichlorotoluene; benzylidene chloride; benzal chloride
202-709-2
98-87-3
Carc. 2; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
acetophenone
202-708-7
98-86-2
Acute Tox. 4; Eye Irrit. 2
2-phenylpropene; α-methylstyrene
202-705-0
98-83-9
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
cumene
202-704-5
98-82-8
Flam. Liq. 3; Carc. 1B; Asp. Tox. 1; STOT SE 3
4-tert-butylbenzoic acid
202-696-3
98-73-7
Repr. 1B; STOT RE 1; Acute Tox. 4
4-tert-butylphenol
202-679-0
98-54-4
Repr. 2; Skin Irrit. 2; Eye Dam. 1
α, α, α-trifluorotoluene; benzotrifluoride
202-635-0
98-08-8
Flam. Liq. 2
α, α, α-trichlorotoluene; benzotrichloride
202-634-5
98-07-7
Carc. 1B; Acute Tox. 3; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
2-furaldehyde
202-627-7
98-01-1
Carc. 2; Acute Tox. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
furfuryl alcohol
202-626-1
98-00-0
Carc. 2; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Irrit. 2; STOT SE 3
Paraffin waxes (coal), brown-coal high-temp tar, silicic acid-treated; Coal Tar Extract [A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with silicic acid for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with silicic acid for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.
308-298-7
97926-78-8
Carc. 1B
Paraffin waxes (coal), brown-coal high-temp tar, clay-treated; Coal Tar Extract [A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with bentonite for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with bentonite for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.
308-297-1
97926-77-7
Carc. 1B
Paraffin waxes (coal), brown-coal high-temp. tar, carbon-treated; Coal Tar Extract [A complex combination of hydrocarbons obtained by the treatment of lignite carbon ization tar with activated carbon for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.]
A complex combination of hydrocarbons obtained by the treatment of lignite carbonization tar with activated carbon for removal of trace constituents and impurities. It consists predominantly of saturated straight and branched chain hydrocarbons having carbon numbers predominantly greater than C12.
308-296-6
97926-76-6
Carc. 1B
Hydrocarbons, C27-42, naphthenic; Baseoil — unspecified
308-290-3
97926-71-1
Carc. 1B
Hydrocarbons, C20-58, hydrotreated; Baseoil — unspecified
308-289-8
97926-70-0
Carc. 1B
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