EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
EU REACH: List of SVHC
esters of 2,4-D
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Acetic acid, (2,4-dichlorophenoxy)-, 2-(ethoxy-methoxy)ethyl ester EC / List no: - | CAS no: 59577-68-3
Acetic acid, (2,4-dichlorophenoxy)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo- EC / List no: - | CAS no: 40797-15-7
Acetic acid, (2,4-dichlorophenoxy)-, 2-(propoxy-methoxy)ethyl ester EC / List no: - | CAS no: 59577-69-4
Acetic acid, (2,4-dichlorophenoxy)-, 2-fluoro-cyclohexyl ester EC / List no: - | CAS no: 52176-63-3
Acetic acid, (2,4-dichlorophenoxy)-, 1,1-dimethyl-ethyl ester EC / List no: - | CAS no: 36304-26-4
Acetic acid, (2,4-dichlorophenoxy)-, 2-chloro-4-nitrophenyl ester EC / List no: - | CAS no: 53640-16-7
1-butoxypropan-2-yl 2-(2,4-dichlorophenoxy)acetate EC / List no: - | CAS no: 3966-11-8
2-ethylhexyl 2,4-dichlorophenoxyacetate EC / List no: 217-673-3 | CAS no: 1928-43-4
2,4-D, 2-octyl ester EC / List no: - | CAS no: 1917-97-1
Acetic acid, (2,4-dichlorophenoxy)-, 4-pentylphenyl ester EC / List no: - | CAS no: 53640-17-8
(2,4-Dichlorophenoxy)acetic acid, (4-hydroxy-3-nitrophenyl)methyl ester EC / List no: - | CAS no: 26351-71-3
Acetic acid, (2,4-dichlorophenoxy)-, 4-chloro-2-nitrophenyl ester EC / List no: - | CAS no: 53640-15-6
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(hexyloxy)-methoxy]ethyl ester EC / List no: - | CAS no: 59577-72-9
Acetic acid, (2,4-dichlorophenoxy)-, 1-methyl-2,4-dioxo-3-phenyl-4-imidazolidinyl ester EC / List no: - | CAS no: 56402-60-9
Acetic acid, (2,4-dichlorophenoxy)-, 2-(butoxy-methoxy)ethyl ester EC / List no: - | CAS no: 59577-70-7
Tetrahydrofurfuryl 2,4-dichlorophenoxyacetate EC / List no: 239-207-8 | CAS no: 15146-99-3
Heptyl 2,4-dichlorophenoxyacetate EC / List no: 217-634-0 | CAS no: 1917-96-0
Acetic acid, (2,4-dichlorophenoxy)-, (3-nitro-4-(phenylsulfinyl)phenyl)methyl ester EC / List no: - | CAS no: 66711-18-0
Acetic acid, (2,4-dichlorophenoxy)-, (2-bromoethyl)-dimethylsilyl ester EC / List no: - | CAS no: 51663-84-4
Acetic acid, (2,4-dichlorophenoxy)-, [4-[(4-methylphenyl)sulfinyl]-3-nitrophenyl]methyl ester EC / List no: - | CAS no: 66711-19-1
Acetic acid, (2,4-dichlorophenoxy)-, 2,3-dihydroxypropyl ester EC / List no: - | CAS no: 28917-83-1
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(2-chloroethoxy)methoxy]ethyl ester EC / List no: - | CAS no: 59577-75-2
Isopropyl 2,4-dichlorophenoxyacetate EC / List no: 202-305-6 | CAS no: 94-11-1
Acetic acid, (2,4-dichlorophenoxy)-, 2-methoxy-cyclohexyl ester EC / List no: - | CAS no: 52176-65-5
2,4-D 3-butoxypropyl ester EC / List no: - | CAS no: 1928-45-6
Methyl 2,4-dichlorophenoxyacetate EC / List no: 217-670-7 | CAS no: 1928-38-7
Isooctyl (2,4-dichlorophenoxy)acetate EC / List no: 246-704-3 | CAS no: 25168-26-7
2-Butoxypropyl (2,4-dichlorophenoxy)acetate EC / List no: - | CAS no: 10463-14-6
Acetic acid, (2,4-dichlorophenoxy)-, 4-chloro-2-butenyl ester EC / List no: - | CAS no: 2971-38-2
Acetic acid, (2,4-dichlorophenoxy)-, 4-pyridinyl ester, N-oxide EC / List no: - | CAS no: 54718-52-4
Acetic acid, (2,4-dichlorophenoxy)-, 2,3,3-trichloro-2-propenyl ester EC / List no: - | CAS no: 29670-84-6
Pentyl (2,4-dichlorophenoxy)acetate EC / List no: 217-631-4 | CAS no: 1917-92-6
Acetic acid, (2,4-dichlorophenoxy)-, 1,3-propane-diyl ester EC / List no: - | CAS no: 28188-32-1
2-butoxyethyl 2,4-dichlorophenoxyacetate EC / List no: 217-680-1 | CAS no: 1929-73-3
1,3-dimethylbutyl 2-(2,4-dichlorophenoxy)acetate EC / List no: 300-531-0 | CAS no: 93941-81-2
2,4-D crotyl ester EC / List no: - | CAS no: 14600-07-8
Acetic acid, (2,4-dichlorophenoxy)-, ethenyl ester, homopolymer EC / List no: - | CAS no: 55972-44-6
Acetic acid, (2,4-dichlorophenoxy)-, ester with 4-hydroxycoumarin EC / List no: - | CAS no: 7565-90-4
Acetic acid, (2,4-dichlorophenoxy)-, 2-(acetyloxy)-ethyl ester EC / List no: - | CAS no: 42313-93-9
Acetic acid, (2,4-dichlorophenoxy)-, 2-butoxymethylethyl ester EC / List no: - | CAS no: 1320-18-9
2,4-D sec-butyl ester EC / List no: - | CAS no: 94-79-1
Butyl 2,4-dichlorophenoxyacetate EC / List no: 202-364-8 | CAS no: 94-80-4
Ethyl 2,4-dichlorophenoxyacetate EC / List no: 208-558-9 | CAS no: 533-23-3
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(octyloxy)-methoxy]ethyl ester EC / List no: - | CAS no: 59577-73-0
Acetic acid, (2,4-dichlorophenoxy)-, (2-chloroethyl)dimethylsilyl ester EC / List no: - | CAS no: 51663-83-3
Acetic acid, (2,4-dichlorophenoxy)-, 3,3-difluoro-2-propenyl ester EC / List no: - | CAS no: 840-85-7
Acetic acid, (2,4-dichlorophenoxy)-, 2-propenyl ester EC / List no: - | CAS no: 58965-05-2
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(pentyloxy)-methoxy]ethyl ester EC / List no: - | CAS no: 59577-71-8
Octyl (2,4-dichlorophenoxy)acetate EC / List no: 217-674-9 | CAS no: 1928-44-5
Isobutyl 2,4-dichlorophenoxyacetate EC / List no: 216-992-5 | CAS no: 1713-15-1
Nitrilotri-2,1-ethanediyl tris[(2,4-dichlorophenoxy)acetate] EC / List no: 299-308-8 | CAS no: 93858-74-3
Acetic acid, (2,4-dichlorophenoxy)-, vinyl ester EC / List no: - | CAS no: 4280-66-4
4-hydroxybutyl (2,4-dichlorophenoxy)acetate EC / List no: 252-929-8 | CAS no: 36227-43-7
Acetic acid, (2,4-dichlorophenoxy)-, dodecyl ester EC / List no: - | CAS no: 62855-71-4
2,4-Dichlorophenoxyacetic acid 2-dimethylaminoethyl ester hydrochloride EC / List no: - | CAS no: 64046-52-2
(2,4-Dichlorophenoxy)acetic acid 2-butoxy-2-oxoethyl ester EC / List no: - | CAS no: 52671-26-8
Acetic acid, (2,4-dichlorophenoxy)-, 2-(1-oxopro-poxy)ethyl ester EC / List no: - | CAS no: 42313-94-0
Acetic acid, (2,4-dichlorophenoxy)-, 2-[(heptyloxy)-methyl]ethyl ester EC / List no: - | CAS no: 59577-74-1
Trimethylsilyl (2,4-dichlorophenoxy)acetate EC / List no: - | CAS no: 34113-76-3
Acetic acid, (2,4-dichlorophenoxy)-, (pentafluorophenyl)methyl ester EC / List no: - | CAS no: 68704-50-7
Acetic acid, (2,4-dichlorophenoxy)-, (4-((4-chlorophenyl)sulfinyl)-3-nitrophenyl)methyl ester EC / List no: - | CAS no: 66711-20-4
Propyl 2,4-dichlorophenoxyacetate EC / List no: 217-677-5 | CAS no: 1928-61-6
Acetic acid, (2,4-dichlorophenoxy)-, 2-hydroxyethyl ester EC / List no: - | CAS no: 38383-43-6
Acetic acid, (2,4-dichlorophenoxy)-, tetrahydro-2-furanyl ester EC / List no: - | CAS no: 51822-88-9
Hexyl 2,4-dichlorophenoxyacetate EC / List no: 217-633-5 | CAS no: 1917-95-9
Nonyl (2,4-dichlorophenoxy)acetate EC / List no: 259-722-1 | CAS no: 55617-55-5
Acetic acid, (2,4-dichlorophenoxy-, 3-iodo-2-propynyl ester EC / List no: - | CAS no: 71983-94-3
Acetic acid, (2,4-dichlorophenoxy)-, 2-(dipropylamino)-1-methylethyl ester EC / List no: - | CAS no: 15887-75-9
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-
Acute Tox. 4; Skin Sens. 1
esters of mecoprop and of mecoprop-P
-
-
Acute Tox. 4; Skin Sens. 1
esters of mecoprop and of mecoprop-P
-
-
Acute Tox. 4; Skin Sens. 1
etacelasil (ISO); 6-(2-chloroethyl)-6-(2-methoxyethoxy)-2,5,7,10-tetraoxa-6-silaundecane
253-704-7
37894-46-5
Repr. 1B; Acute Tox. 4; STOT RE 2
ethane
200-814-8
74-84-0
Flam. Gas 1; Press. Gas
ethanediol; ethylene glycol
203-473-3
107-21-1
Acute Tox. 4
ethanethiol; ethyl mercaptan
200-837-3
75-08-1
Flam. Liq. 2; Acute Tox. 4
ethanol, 2,2'-iminobis-, N-(C13-15-branched and linear alkyl) derivs.
308-208-6
97925-95-6
Repr. 1B
ethanol; ethyl alcohol
200-578-6
64-17-5
Flam. Liq. 2
ethephon; 2-chloroethylphosphonic acid
240-718-3
16672-87-0
Acute Tox. 3; Acute Tox. 4; Skin Corr. 1C
ethidimuron (ISO); 1-(5-ethylsulphonyl-1,3,4-thiadiazol-2-yl)-1,3-dimethylurea
250-010-6
30043-49-3
Skin Sens. 1
ethidium bromide; 3,8-diamino-1-ethyl-6-phenylphenantridinium bromide
214-984-6
1239-45-8
Muta. 2; Acute Tox. 2; Acute Tox. 4
ethiofencarb (ISO); 2-(ethylthiomethyl)phenyl N-methylcarbamate
249-981-9
29973-13-5
Acute Tox. 4
ethion (ISO); O, O,O',O'-tetraethyl S, S'-methylenedi (phosphorodithioate); diethion
209-242-3
563-12-2
Acute Tox. 3; Acute Tox. 4
ethirimol (ISO); 5-butyl-2-ethylamino-6-methylpyrimidin-4-ol
245-949-3
23947-60-6
Acute Tox. 4
ethoate-methyl (ISO); ethylcarbamoylmethyl O,O-dimethyl phosphorodithioate
204-121-1
116-01-8
Acute Tox. 4
ethoprophos (ISO); ethyl-S,S-dipropyl phosphorodithioate
236-152-1
13194-48-4
Acute Tox. 2; Acute Tox. 1; Acute Tox. 3; Skin Sens. 1
ethoxyquin (ISO); 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline
202-075-7
91-53-2
Acute Tox. 4
ethyl (1S, 5R, 6S)-5-(1-ethylpropoxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylate
429-020-1
204254-96-6
STOT RE 2; Skin Sens. 1
ethyl (3-cyanomethyl-3,4-dihydro-4-oxophthalazin-1-yl)acetate
429-680-0
122665-86-5
Skin Sens. 1
ethyl (3R)-4-cyano-3-hydroxybutanoate
430-220-6
141942-85-0
Eye Irrit. 2
ethyl (S)-2-hydroxypropionate; ethyl L-lactate; ethyl-(S)-lactate
211-694-1
687-47-8
Flam. Liq. 3; STOT SE 3; Eye Dam. 1
ethyl 1-(2,4-dichlorophenyl)-5-(trichloromethyl)-1H-1,2,4-triazole-3-carboxylate
HOE 70542
401-290-5
103112-35-2
Carc. 1B
ethyl 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate
DM-8
405-880-3
100501-62-0
Skin Sens. 1
ethyl 2-(1-cyanocyclohexyl)acetate
GABAPENTINE ETHYL ESTER; PD 137016
415-970-4
133481-10-4
Acute Tox. 4; STOT RE 2
ethyl 2-(3-benzoylphenyl)propanoate
414-920-9
60658-04-0
Acute Tox. 3; STOT RE 1; Skin Sens. 1
ethyl 2-(3-nitrobenzylidene)acetoacetate
3-NITROBENZYLIDENETHYLESTER
404-490-0
39562-16-8
Eye Dam. 1; Skin Sens. 1
ethyl 2-(4-phenoxyphenyl)lactate
429-220-9
132584-17-9
Skin Sens. 1
ethyl 2-(isocyanatosulfonyl)benzoate
EPSI
410-220-2
77375-79-2
Acute Tox. 4; STOT RE 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
ethyl 2-[4-[(6-chlorobenzoxazol-2-yl)oxy]phenoxy]propionate; fenoxaprop-ethyl
266-362-9
66441-23-4
Skin Sens. 1
ethyl 2-carboxy-3-(2-thienyl)propionate
SB-201999
415-680-8
143468-96-6
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
ethyl 2-cyanoacrylate
230-391-5
7085-85-0
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
ethyl 2-ethoxy-4-carboxymethylbenzoate
ECPA
427-630-2
99469-99-5
Eye Dam. 1
ethyl 3,3-bis(tert-pentylperoxy)butyrate
LUPEROX 533
403-320-2
67567-23-1
Org. Perox. D; Flam. Liq. 3
ethyl 3-hydroxy-5-oxo-3-cyclohexene-1-carboxylate
CA 875 B
414-450-4
88805-65-6
Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
ethyl 4-((4-diethylamino-2-methylphenyl)imino)-4,5-dihydro-1-isopropyl-5-oxo-1H-pyrazole-3-carboxylate
427-110-5
948991-29-5
Acute Tox. 4; STOT RE 2
ethyl 5,5-diphenyl-2-isoxazoline-3-carboxylate
443-870-0
163520-33-0
Acute Tox. 4; Skin Sens. 1
ethyl 6,8-dichlorooctanoate
6,8-DICHLORETHYLCAPRYLAT; ETHYL-6,8 DICHLORO OCTANOATE
435-080-1
1070-64-0
Skin Sens. 1
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate
422-360-1
100491-29-0
Skin Sens. 1
ethyl acetate
205-500-4
141-78-6
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3
ethyl acrylate
205-438-8
140-88-5
Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
ethyl bromoacetate
203-290-9
105-36-2
Acute Tox. 2; Acute Tox. 1
ethyl chloroacetate
203-294-0
105-39-5
Acute Tox. 3
ethyl chloroformate
208-778-5
541-41-3
Flam. Liq. 2; Acute Tox. 2; Acute Tox. 4; Skin Corr. 1B
ethyl cis-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine-1-carboxylate
428-030-3
67914-69-6
Acute Tox. 4; STOT RE 2
ethyl formate
203-721-0
109-94-4
Flam. Liq. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
ethyl hydrogen sulfate, nickel(II) salt
275-897-7
71720-48-4
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
ethyl lactate; ethyl DL-lactate
202-598-0
97-64-3
Flam. Liq. 3; STOT SE 3; Eye Dam. 1
ethyl methacrylate
202-597-5
97-63-2
Flam. Liq. 2; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
ethyl methyl ether
611-089-6
540-67-0
Flam. Gas 1; Press. Gas
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