EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 18 April 2024. Database contains 4753 unique substances/entries.

Filter the list

Showing 1,701 - 1,750 of 4,753 results.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)	EU_BA Directive 2000/54/EC	EU REACH: List of SVHC
coumatetralyl; 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin	227-424-0	5836-29-3	Repr. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1
coumithoate (ISO); O,O-diethyl O-7,8,9,10-tetrahydro-6-oxo-benzo(c)chromen-3-yl phosphorothioate	-	572-48-5	Acute Tox. 3
Cowpox virus	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Coxiella burnetii	-	-		B Bacteria and similar species
Coxsackie viruses	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Creosote [The distillate of coal tar produced by the high temperature carbonization of bituminous coal. It consists primarily of aromatic hydrocarbons, tar acids and tar bases.] The distillate of coal tar produced by the high temperature carbonization of bituminous coal. It consists primarily of aromatic hydrocarbons, tar acids and tar bases.	232-287-5	8001-58-9	Carc. 1B
Creosote oil [ complex combination of hydrocarbons obtained by the distillation of coal tar. It consists primarily of aromatic hydrocarbons and may contain appreciable quantities of tar acids and tar bases. It distills at the approximate range of 200 °C to 325 °C (392°F to 617°F).] A complex combination of hydrocarbons obtained by the distillation of coal tar. It consists primarily of aromatic hydrocarbons and may contain appreciable quantities of tar acids and tar bases. It distills at the approximate range of 200°C to 325°C (392°F to 617°F).	263-047-8	61789-28-4	Carc. 1B
Creosote oil, acenaphthene fraction, acenaphthene-free; Wash Oil Redistillate [The oil remaining after removal by a crystallization process of acenaphthene from acenaphthene oil from coal tar. Composed primarily of naphthalene and alkylnaphthalenes.] The oil remaining after removal by a crystallization process of acenaphthene from acenaphthene oil from coal tar. Composed primarily of naphthalene and alkylnaphthalenes.	292-606-9	90640-85-0	Carc. 1B
Creosote oil, acenaphthene fraction; Wash Oil [ complex combination of hydrocarbons produced by the distillation of coal tar and boiling in the range of approximately 240 o C to 280 o C (464°F to 536 °F). Composed primarily of acenaphthene, naphthalene and alkyl naphthalene.] A complex combination of hydrocarbons produced by the distillation of coal tar and boiling in the range of approximately 240°C to 280°C (464°F to 536°F). Composed primarily of acenaphthene, naphthalene and alkyl naphthalene.	292-605-3	90640-84-9	Carc. 1B
Creosote oil, high-boiling distillate; Wash Oil [The high-boiling distillation fraction obtained from the high temperature carbonization of bituminous coal which is further refined to remove excess crystalline salts. It consists primarily of creosote oil with some of the normal polynuclear aromatic salts, which are components of coal tar distillates, removed. It is crystal free at approximately 5 °C (41°F).] The high-boiling distillation fraction obtained from the high temperature carbonization of bituminous coal which is further refined to remove excess crystalline salts. It consists primarily of creosote oil with some of the normal polynuclear aromatic salts, which are components of coal tar distillates, removed. It is crystal free at approximately 5°C (41°F).	274-565-9	70321-79-8	Carc. 1B
Creosote oil, low-boiling distillate; Wash Oil [he low-boiling distillation fraction obtained from the high temperature carbonization of bituminous coal, which is further refined to remove excess crystalline salts. It consists primarily of creosote oil with some of the normal polynuclear aromatic salts, which are components of coal tar distillate, removed. It is crystal free at approximately 38 o C (100 oF).] The low-boiling distillation fraction obtained from the high temperature carbonization of bituminous coal, which is further refined to remove excess crystalline salts. It consists primarily of creosote oil with some of the normal polynuclear aromatic salts, which are components of coal tar distillate, removed. It is crystal free at approximately 38°C (100°F).	274-566-4	70321-80-1	Carc. 1B
Creutzfeldt-Jakob disease	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
Crimean-Congo haemorrhagic fever	-	-		V Viruses: Member States are to ensure that all viruses which have already been isolated in humains and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
crimidine (ISO);2-chloro-6-methylpyrimidin-4- yldimethylamine	208-622-6	535-89-7	Acute Tox. 2
crotonaldehyde; 2-butenal	224-030-0	4170-30-3	Flam. Liq. 2; Muta. 2; Acute Tox. 2; Acute Tox. 3; STOT RE 2; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
crotoxyphos (ISO); 1-phenylethyl 3-(dimethoxyphosphinyloxy) isocrotonate	231-720-5	7700-17-6	Acute Tox. 3
crufomate (ISO); 4-tert-butyl-2-chlorophenyl methyl methylphosphoramidate	206-083-1	299-86-5	Acute Tox. 4
Cryptococcus neoformans var. gattii	-	-		F Fungi
Cryptococcus neoformans var. neofonnans	-	-		F Fungi
Cryptosporidium parvum	-	-		P Parasites
Cryptosporidium spp.	-	-		P Parasites
cumene	202-704-5	98-82-8	Flam. Liq. 3; Asp. Tox. 1; STOT SE 3
cyanamide; carbanonitril	206-992-3	420-04-2	Carc. 2; Repr. 2; Acute Tox. 3; STOT RE 2; Skin Corr. 1; Skin Sens. 1; Eye Dam. 1
cyanazine (ISO);2-(4-chloro-6-ethylamino-1,3,5- triazine-2-ylamino)-2-methylpropionitrile	244-544-9	21725-46-2	Acute Tox. 4
cyanofenphos (ISO); O-4-cyanophenyl O-ethyl phenylphosphonothioate	620-377-0	13067-93-1	Acute Tox. 3; STOT SE 1; Acute Tox. 4; Eye Irrit. 2
cyanophos (ISO); O-4-cyanophenyl O,O-dimethyl phosphorothioate	220-130-3	2636-26-2	Acute Tox. 4
cyanthoate (ISO); S-(N-(1-cyano-1-methylethyl)carbamoylmethyl) O,O-diethyl phosphorothioate	223-099-4	3734-95-0	Acute Tox. 2; Acute Tox. 3
cyclanilide (ISO); 1-(2,4-dichloroanilinocarbonyl)cyclopropanecarboxylic acid CSDCA	419-150-7	113136-77-9	Acute Tox. 4
cyclic 3-(1,2-ethanediylacetale)-estra-5(10),9(11)-diene-3,17-dione	427-230-8	5571-36-8	Repr. 1B; STOT RE 2
cyclohexadeca-1,9-diene	431-730-1	4277-06-9	Skin Irrit. 2; Skin Sens. 1
cyclohexane	203-806-2	110-82-7	Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
cyclohexane-1,2-dicarboxylic anhydride	201-604-9	85-42-7	Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1		yes
cyclohexanol	203-630-6	108-93-0	Acute Tox. 4; STOT SE 3; Skin Irrit. 2
cyclohexanone	203-631-1	108-94-1	Flam. Liq. 3; Acute Tox. 4
cyclohexanone, peroxide [> 91 % solution];cyclohexanone, peroxide [≤ 91 % solution]	235-527-7	12262-58-7	Org. Perox. C; Acute Tox. 4; Skin Corr. 1B
cyclohexanone, peroxide [> 91 % solution];cyclohexanone, peroxide [≤ 91 % solution]	235-527-7	12262-58-7	Org. Perox. A; Skin Corr. 1B; Acute Tox. 4
cycloheximide (ISO);4-{(2R)-2-[(1S,3S,5S)-3,5- dimethyl-2-oxocyclohexyl]-2- hydroxyethyl}piperidine-2,6- dione	200-636-0	66-81-9	Muta. 2; Repr. 1B; Acute Tox. 2
cyclohexyl acrylate	221-319-3	3066-71-5	STOT SE 3; Skin Irrit. 2
cyclohexylamine	203-629-0	108-91-8	Flam. Liq. 3; Repr. 2; Acute Tox. 4; Skin Corr. 1B
cyclohexyldimethoxymethylsilane CHMMS; CHMS; DYNASYLAN 9407; Z-6187	402-140-1	17865-32-6	Skin Irrit. 2
cyclohexylidene hydroperoxide [> 91 % solution];cyclohexylidene hydroperoxide [≤ 91 % solution]	220-279-4	2699-11-8	Org. Perox. C; Acute Tox. 4; Skin Corr. 1B
cyclohexylidene hydroperoxide [> 91 % solution];cyclohexylidene hydroperoxide [≤ 91 % solution]	220-279-4	2699-11-8	Org. Perox. A; Skin Corr. 1B; Acute Tox. 4
cyclooct-4-en-1-yl methyl carbonate VIOLIFF	401-620-8	87731-18-8	Skin Sens. 1
cyclopentane	206-016-6	287-92-3	Flam. Liq. 2
cyclopentane-1,2,3,4-tetracarboxylic dianhydride	227-964-7	6053-68-5	Eye Irrit. 2; STOT SE 3
cyclopentanone	204-435-9	120-92-3	Flam. Liq. 3; Eye Irrit. 2; Skin Irrit. 2
cyclopentyl 2-phenylethyl ether	428-340-9	238088-70-5	Skin Irrit. 2
cyclopentyl chloroformate CHLOROFORMIATE DE CYCLOPENTYLE; CYCLOPENTYLCHLORFORMIAT	411-460-0	50715-28-1	Flam. Liq. 3; Acute Tox. 3; Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1
cyclopropane	200-847-8	75-19-4	Flam. Gas 1; Press. Gas
Cyclospora cayetanensis	-	-		P Parasites

Showing 1,701 - 1,750 of 4,753 results.

Export search results to:

EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

RELEVANT LEGISLATION

Contact EUCLEF Helpdesk

Last updated 18 April 2024. Database contains 4753 unique substances/entries.

Footer Nav Items