EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 19 April 2024. Database contains 4753 unique substances/entries.
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250-517-2
31218-83-4
Acute Tox. 3
206-326-1
327-98-0
Acute Tox. 2; Acute Tox. 3
222-182-2
3380-34-5
Eye Irrit. 2; Skin Irrit. 2
206-203-2
307-55-1
yes
222-979-5
3687-31-8
yes
442-960-7
332350-93-3
Acute Tox. 3; Eye Dam. 1
TRYPROPYLAMMONIUM DIHYDROGENPHOSPHAT
433-700-3
35687-90-2
Acute Tox. 4
440-480-2
341026-59-3
Eye Dam. 1; Skin Sens. 1
256-032-2
42978-66-5
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
443-840-7
4084-38-2
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
CLETOPROPAMINHYDROCHLORID
429-740-6
40722-80-3
Carc. 1B; Muta. 1B; STOT RE 2; Skin Sens. 1
17-KETOBROMOHYDRINE
419-790-7
4229-69-0
Skin Sens. 1
421-830-3
49805-30-3
Acute Tox. 4; Skin Sens. 1
224-168-1
4221-99-2
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3
430-250-1
406-58-6
Flam. Liq. 2
-
4482-55-7
Skin Irrit. 2
RO 1173
414-270-6
41959-35-7
Acute Tox. 4
256-152-5
43222-48-6
Acute Tox. 4
431-450-1
41870-52-4
Skin Irrit. 2
1-BROM-3,5-DIFLUORBENZOL; 1-BROMO-3,5-DIFLUOROBENZENE; BDFB
416-710-2
461-96-1
Flam. Liq. 3; Acute Tox. 4; STOT RE 2; Skin Irrit. 2; Skin Sens. 1
225-208-0
4719-04-4
Acute Tox. 4; Skin Sens. 1
TG-SA
411-570-9
41481-66-7
Skin Sens. 1
223-791-6
4074-88-8
Acute Tox. 3; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
207-346-3
464-06-2
Flam. Liq. 2; Asp. Tox. 1; Skin Irrit. 2; STOT SE 3
207-343-7
463-82-1
Flam. Gas 1; Press. Gas
2,3,4,5-TETRACHLORBENZOYLCHLORID
406-760-3
42221-52-3
Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
255-853-3
42498-58-8
Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
GUAIACOL-O-ETHYLBROMIDE
402-010-4
4463-59-6
Acute Tox. 4
7-ETHYLTRYPTOPHOL
431-020-1
41340-36-7
Acute Tox. 4; STOT RE 2
431-930-9
43028-69-9
Acute Tox. 4; Skin Sens. 1
429-560-8
4274-38-8
Skin Corr. 1B; Acute Tox. 4; STOT RE 2; Skin Sens. 1
429-430-0
444-14-4
Acute Tox. 4
2-CHLOR-4-TOLUOLSULFONYLCHLORID
412-890-1
42413-03-6
Skin Corr. 1B; Skin Sens. 1
424-380-6
43057-68-7
Acute Tox. 4; STOT RE 2
PARADISAMIDE
446-190-2
406488-30-0
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
444-860-9
474510-57-1
STOT RE 2
THANCAT AN 10
404-810-9
4524-95-2
Flam. Liq. 3; Acute Tox. 4; STOT RE 2; Skin Corr. 1B
SUBSTANCE S123386; VANQUISH 100
420-590-7
4299-07-4
Skin Corr. 1B; Skin Sens. 1
AF-368
406-400-5
4595-26-0
STOT RE 2; Skin Irrit. 2; Skin Sens. 1
223-775-9
4067-16-7
Skin Corr. 1B; Skin Sens. 1
HYPO-LEM
403-620-3
40188-41-8
Skin Irrit. 2; Skin Sens. 1
SUBSTANCE S68494
412-230-2
4403-70-7
Acute Tox. 4; Skin Corr. 1B
223-861-6
4098-71-9
Acute Tox. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
207-762-5
492-80-8
Carc. 2; Acute Tox. 4; Eye Irrit. 2
ZP-DK 2115
407-590-2
43151-99-1
Acute Tox. 3; STOT RE 2; Skin Sens. 1
AROCY L-10
405-740-1
47073-92-7
Acute Tox. 4; STOT RE 2; Eye Dam. 1
223-810-8
4083-64-1
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
BICH-3 STUFE 3
406-810-4
40649-36-3
Skin Irrit. 2
123U83; DDFU
415-360-8
41107-56-6
Muta. 2
619-823-7
494793-67-8
Carc. 2

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