EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 24 May 2024. Database contains 4753 unique substances/entries.
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218-575-3
2186-25-6
Muta. 2; Skin Irrit. 2; Skin Sens. 1
218-574-8
2186-24-5
Muta. 2; Skin Irrit. 2; Skin Sens. 1
247-711-4
26447-14-3
Muta. 2; Skin Irrit. 2; Skin Sens. 1
NITROGELB
410-700-1
27080-42-8
Skin Sens. 1
219-943-6
2580-56-5
yes
247-118-0
25584-83-2
Acute Tox. 3; Skin Corr. 1B; Skin Sens. 1
435-660-2
243662-67-1
Skin Irrit. 2; Skin Sens. 1
244-088-0
20859-73-8
Water-react. 1; Acute Tox. 2; Acute Tox. 3; Acute Tox. 1
217-990-7
2032-59-9
Acute Tox. 3
441-050-7
223705-57-5
Skin Irrit. 2; Eye Dam. 1
249-415-0
29081-56-9
Carc. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Lact.
221-037-0
2980-64-5
Acute Tox. 2; Acute Tox. 1; STOT RE 2
220-147-6
2642-71-9
Acute Tox. 2; Acute Tox. 3
244-214-4
21109-95-5
Acute Tox. 4
245-216-8
22781-23-3
Acute Tox. 3; Acute Tox. 2
246-585-8
25057-89-0
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
205-911-9
205-99-2
Carc. 1B
HWL-158
432-590-4
243869-48-9
Eye Irrit. 2
205-910-3
205-82-3
Carc. 1B
205-916-6
207-08-9
Carc. 1B
yes
219-348-1
2421-28-5
Eye Irrit. 2; STOT SE 3
B2,4DBB
420-710-8
23085-60-1
Repr. 2; Skin Irrit. 2; Skin Sens. 1
249-205-9
28772-56-7
Repr. 1B; Acute Tox. 1; STOT RE 1
218-277-3
2104-96-3
Acute Tox. 4
219-376-4
2426-08-6
Flam. Liq. 3; Carc. 2; Muta. 2; Acute Tox. 4; STOT SE 3; Skin Sens. 1
220-600-8
2832-40-8
Carc. 2; Skin Sens. 1
244-168-5
21041-95-2
Carc. 1B; Muta. 1B; Acute Tox. 4; STOT RE 1
yes
243-873-5
20548-54-3
Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
219-363-3
2425-06-1
Carc. 1B; Skin Sens. 1
246-538-1
24934-91-6
Acute Tox. 1; Acute Tox. 2
247-109-1
25567-67-3
Acute Tox. 3; STOT RE 2
246-691-4
25167-80-0
Acute Tox. 4
246-698-2
25168-05-2
Acute Tox. 4
220-864-4
2921-88-2
Acute Tox. 3
244-663-6
21923-23-9
Acute Tox. 2; Acute Tox. 3
205-923-4
218-01-9
Carc. 1B; Muta. 2
yes
246-948-0
25402-06-6
Acute Tox. 4
245-119-0
22605-92-1
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
433-460-1
210880-92-5
Acute Tox. 4
243-815-9
20427-59-2
Acute Tox. 2; Acute Tox. 4; Eye Dam. 1
206-083-1
299-86-5
Acute Tox. 4
244-544-9
21725-46-2
Acute Tox. 4
220-130-3
2636-26-2
Acute Tox. 4
220-279-4
2699-11-8
Org. Perox. C; Acute Tox. 4; Skin Corr. 1B
220-279-4
2699-11-8
Org. Perox. A; Skin Corr. 1B; Acute Tox. 4
206-016-6
287-92-3
Flam. Liq. 2
428-340-9
238088-70-5
Skin Irrit. 2
218-827-2
2244-16-8
Skin Sens. 1
219-971-9
2587-90-8
Acute Tox. 2; Acute Tox. 3
206-053-8
298-03-3
Acute Tox. 1; Acute Tox. 2

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