EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 08 December 2023. Database contains 4753 unique substances/entries.

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Showing 51 - 100 of 4,753 results.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)	EU REACH: List of SVHC
turpentine, oil Any of the volatile predominately terpenic fractions or distillates resulting from the solvent extraction of, gum collection from, or pulping of softwoods. Composed primarily of the C10H16 terpene hydrocarbons: α-pinene, β-pinene, limonene, 3-carene, camphene. May contain other acyclic, monocyclic, or bicyclic terpenes, oxygenated terpenes, and anethole. Exact composition varies with refining methods and the age, location, and species of the softwood source.	232-350-7	8006-64-2	Flam. Liq. 3; Acute Tox. 4; Asp. Tox. 1; Eye Irrit. 2; Skin Irrit. 2; Skin Sens. 1
trypsin	232-650-8	9002-07-7	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1
troclosene sodium, dihydrate	610-700-3	51580-86-0	Acute Tox. 4; Eye Irrit. 2; STOT SE 3
troclosene sodium	220-767-7	2893-78-9	Ox. Sol. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
troclosene potassium	218-828-8	2244-21-5	Ox. Sol. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
trizinc diphosphide; zinc phosphide	215-244-5	1314-84-7	Water-react. 1; Acute Tox. 2
trixylyl phosphate	246-677-8	25155-23-1	Repr. 1B	yes
tritosulfuron (ISO) (containing ≤0,02 % AMTT); 1-[4-methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-yl]-3-[2-(trifluoromethyl)benzenesulfonyl]urea (containing ≤ 0,02 % AMTT)	604-291-0	142469-14-5	Skin Sens. 1
trisodium(2-(α-(3-(4-chloro-6-(2-(2-(vinylsulfonyl)ethoxy)ethylamino)-1,3,5-triazin-2-ylamino)-2-oxido-5-sulfonatophenylazo)benzylidenehydrazino)-4-sulfonatobenzoato)copper(II) REACTIVE BLUE 245	407-580-8	130201-51-3	Eye Dam. 1
trisodium nitrilotriacetate	225-768-6	5064-31-3	Carc. 2; Acute Tox. 4; Eye Irrit. 2
trisodium N-(3-propionato)-l-aspartate	422-090-4	172737-80-3	Eye Dam. 1
trisodium N, N-bis(carboxymethyl)-β-alanine TRILON(R) ES 9851	414-070-9	129050-62-0	Skin Corr. 1B
trisodium N, N-bis(carboxymethyl)-3-amino-2-hydroxypropionate TRILON(R) ES 9910	414-130-4	119710-96-2	Acute Tox. 4
trisodium hexafluoroaluminate(cryolite)	239-148-8	15096-52-3	STOT RE 1; Acute Tox. 4
trisodium hexafluoroaluminate	237-410-6	13775-53-6	STOT RE 1; Acute Tox. 4
trisodium bis[(3'-nitro-5'-sulfonato(6-amino-2-[4-(2-hydroxy-1-naphtylazo)phenylsulfonylamino]pyrimidin-5-azo)benzene-2',4-diolato)]chromate(III) RED JB 747	418-220-4	-	Skin Sens. 1
trisodium bis(7-acetamido-2-(4-nitro-2-oxidophenylazo)-3-sulphonato-1-naphtholato)chromate(1-) BI 3277; NOIR CORSE SANODAL H3LW CONC.; SANODAL DEEP BLACK H-3LW CONC.; SANODAL TIEFSCHWARZ H-3LW; SANODAL TIEFSCHWARZ H-3LW KONZ.	400-810-8	106084-79-1	Muta. 2
trisodium bis(2-(5-chloro-4-nitro-2-oxidophenylazo)-5-sulphonato-1-naphtholato)chromate(1-) ACID BLUE 349; AZO-METALCOMPLEX-BLUE AP 1149; BLEU ACIDE 349; C.I. ACID BLUE 349; SELLASET BLEU H; SELLASET BLUE H	402-870-0	93952-24-0	Eye Dam. 1
trisodium [4'-(8-acetylamino-3,6-disulfonato-2-naphthylazo)-4''-(6-benzoylamino-3-sulfonato2-naphthylazo)-biphenyl 1,3',3'',1'''-tetraolato-O,O',O'',O''']copper(II) SOLAMINLICHTBLAU VGRL 133	413-590-3	164058-22-4	Carc. 1B
trisodium [2-(5-chloro-2,6-difluoropyrimidin-4-ylamino)-5-(b-sulfamoyl-c, d-sulfonatophthalocyanin-a-yl-K4, N29, N30, N31, N32-sulfonylamino)benzoato(5-)]cuprate(II) where a =1,2,3,4 b = 8,9,10,11 c = 15,16,17,18 d = 22,23,24,25 TURQUOISE 10 40 518	411-430-7	-	Eye Dam. 1; Skin Sens. 1
trisodium [1,2'-(2-(8-amino-3,5-disulfonatonaphthalene)azo)-(4'-nitrobenzene)diolato-O, O,N][(Z)-2,2-((phenylcarbamoylprop-1'-enyl)azo)-5-sulfamoylbenzene)diolato-O, O,N]chromate(III)	423-100-1	-	Eye Dam. 1
trisodium 7-(4-(6-fluoro-4-(2-(2-vinylsulphonylethoxy)ethylamino)-1,3,5-triazin-2-ylamino)-2-ureidophenylazo)naphthalene-1,3,6-trisulphonate C.I. REACTIVE YELLOW 174; GIALLO REATTIVO 174; JAUNE REACTIF 174; REAKTIV GELB 174	402-170-5	106359-91-5	Skin Sens. 1
trisodium 5-{[4-chloro-6-(1-naphthylamino)-1,3,5-triazin-2-yl]amino}-4-hydroxy-3-[(E)-(4-methoxy-2-sulfonatophenyl)diazenyl]-2,7-naphthalenedisulfonate	440-480-2	341026-59-3	Eye Dam. 1; Skin Sens. 1
trisodium 4-hydroxy-6-(sulfonatomethylamino)-5-(2-(2-sulfatoethylsulfonyl)phenylazo)naphthalene-2-sulfonate	430-280-3	844491-96-9	Skin Sens. 1
trisodium 3-amino-6,13-dichloro-10-((3-((4-chloro-6-(2-sulfophenylamino)-1,3,5-triazin-2-yl)amino)propyl) amino)-4,11-triphenoxydioxazinedisulfonate BLEU REACTIF CAC 10; DIOXAZINE MONCHLORTRIAZINE; FAT NO. 40 407; REACTIVE BLUE CAC 10	410-130-3	136248-03-8	Skin Sens. 1
trisodium 3-amino-4-[4-[4-(2-(2-ethenylsulfonylethoxy)ethylamino)-6-fluoro-1,3,5-triazine-2-ylamino]-2-sulfophenylazo]-5-hydroxynaphthalene-2,7-disulfonate	429-240-8	212652-59-0	Eye Dam. 1
trisodium 3-[2-acetylamino-4-[4-chloro-6-[4-(2-sulfonatoxyethylsulfonyl)phenylamino]-1,3,5-triazine-2-ylamino]phenylazo]naphthalene-1,5-disulfonate	427-710-7	215612-56-9	Eye Dam. 1; Skin Sens. 1
trisodium 2-{α[2-hydroxy-3-[4-chloro-6-[4-(2,3-dibromopropionylamino)-2-sulfonatophenylamino]-1,3,5-triazin-2-ylamino]-5-sulfonatophenylazo]-benzylidenehydrazino}-4-sulfonatobenzoate, copper complex BLUE TZ 4312	423-770-3	-	Eye Dam. 1
trisodium 1-hydroxynaphthalene-2-azo-4'(5',5''-dimethylbiphenyl)-4''-azo(4''-phenylsulfonyloxybenzene)-2',2'',4-trisulfonate SCARLET 12 04 262	406-820-9	159317-41-6	Eye Irrit. 2
trisodium (6-anilino-2-(5-nitro-2-oxidophenylazo)-3-sulphonato-1-naphtholato)(4-sulphonato-1,1'-azodi-2,2'naphtholato)chromate(1-) SÄUREBLAU 82 226	402-500-8	104105-46-6	Eye Dam. 1
trisodium (1-(3-carboxylato-2-oxido-5-sulfonatophenylazo)-5-hydroxy-7-sulfonatonaphthalen-2-amido)nickel(II) BROWN 1612969	407-110-1	480445-87-2	Eye Dam. 1; Skin Sens. 1
tris[2-chloro-1-(chloromethyl)ethyl] phosphate	237-159-2	13674-87-8	Carc. 2
tris(tetramethylammonium) 5-hydroxy-1-(4-sulphonatophenyl)-4-(4-sulphonatophenylazo)pyrazole-3-carboxylate LEXMARK YELLOW DYE 415; PRISM YELLOW	406-073-9	131013-81-5	Acute Tox. 3
tris(octadec-9-enylammonium) (trisulfonatophthalocyaninato)copper(II) PIGMENTBLAU 1755	403-210-4	108300-90-9	Eye Dam. 1
tris(nonylphenyl) phosphite	247-759-6	26523-78-4	Skin Sens. 1	yes
Tris(4-nonylphenyl, branched) phosphite show/hide Tris(nonylphenyl) phosphite EC / List no: 247-759-6 \| CAS no: 26523-78-4 Phenol, 4-nonyl-, phosphite (3:1) EC / List no: 608-492-4 \| CAS no: 3050-88-2 Phenol, p-isononyl-, phosphite (3:1) EC / List no: - \| CAS no: 31631-13-7 Phenol, p-sec-nonyl-, phosphite EC / List no: - \| CAS no: 106599-06-8 tris(4-nonylphenyl, branched) phosphite EC / List no: 701-028-2 \| CAS no: -	799-976-5	-		yes
tris(2-methoxyethoxy)vinylsilane; 6-(2-methoxyethoxy)-6-vinyl-2,5,7,10-tetraoxa-6-silaundecane	213-934-0	1067-53-4	Repr. 1B
tris(2-chloroethyl)phosphate	204-118-5	115-96-8	Carc. 2; Repr. 1B; Acute Tox. 4	yes
tris(2-(2-hydroxyethoxy)ethyl)ammonium 3-acetoacetamido-4-methoxybenzenesulfonate ACETOACETYLORTHOSINIC ACID, A6-SALT	403-760-5	68030-79-5	Skin Sens. 1
tris(1-dodecyl-3-methyl-2-phenylbenzimidazolium)hexacyanoferrate	-	7276-58-6	Acute Tox. 4
tripropyltin compounds, with the exception of those specified elsewhere in this Annex	-	-	Acute Tox. 3
tripropylammonium dihydrogenphosphate TRYPROPYLAMMONIUM DIHYDROGENPHOSPHAT	433-700-3	35687-90-2	Acute Tox. 4
triphenyltin compounds, with the exception of those specified elsewhere in this Annex	-	-	Acute Tox. 3
triphenyl(phenylmethyl)phosphonium 1,1,2,2,3,3,4,4,4-nonafluoro-N-methyl-1-butanesulfonamide (1:1)	442-960-7	332350-93-3	Acute Tox. 3; Eye Dam. 1
triphenyl phosphite	202-908-4	101-02-0	Eye Irrit. 2; Skin Irrit. 2
trioctyltin compounds, with the exception of those specified elsewhere in this Annex	-	-	Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
trioctylstannane TZ 02508	413-320-4	869-59-0	STOT RE 1; Skin Irrit. 2
trinickel tetrasulfide	-	12137-12-1	Carc. 1A; STOT RE 1; Skin Sens. 1
trinickel disulfide; nickel subsulfide	234-829-6	12035-72-2	Carc. 1A; Muta. 2; STOT RE 1; Skin Sens. 1
trinickel boride	234-495-1	12007-02-2	Carc. 1A; STOT RE 1; Skin Sens. 1

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Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

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Last updated 08 December 2023. Database contains 4753 unique substances/entries.