EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

Last updated 23 April 2024. Database contains 4753 unique substances/entries.

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Showing 1,651 - 1,700 of 4,753 results.

Substance Name	EC No.	CAS No.	EU CLP (1272/2008)	EU REACH: List of SVHC
benazolin (ISO); 4-chloro-2,3-dihydro-2-oxo-1,3-benzothiazol-3-ylacetic acid	223-297-0	3813-05-6	Eye Irrit. 2; Skin Irrit. 2
bendiocarb (ISO); 2,2-dimethyl-1,3-benzodioxol-4-yl N-methylcarbamate	245-216-8	22781-23-3	Acute Tox. 3; Acute Tox. 2
benfuracarb (ISO); ethyl N-[2,3-dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl(methyl)aminothio]-N-isopropyl-β-alaninate	617-356-3	82560-54-1	Repr. 2; Acute Tox. 3; Acute Tox. 4
benomyl (ISO);methyl 1-(butylcarbamoyl)benzimidazol-2-ylcarbamate	241-775-7	17804-35-2	Muta. 1B; Repr. 1B; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
benquinox (ISO); p-benzoquinone 1-benzoylhydrazone 4-oxime	207-807-9	495-73-8	Acute Tox. 3; Acute Tox. 4
bensulide (ISO); O, O-diisopropyl 2-phenylsulphonylaminoethyl phosphorodithioate	212-010-4	741-58-2	Acute Tox. 4
bensultap (ISO); 1,3-bis(phenylsulfonylthio)-2-(N,N-dimethylamino)propane	605-769-1	17606-31-4	Acute Tox. 4
bentazone (ISO);3-isopropyl-2,1,3-benzothiadiazine-4-one-2,2-dioxide	246-585-8	25057-89-0	Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
benz[a]anthracene	200-280-6	56-55-3	Carc. 1B	yes
benz[e]acephenanthrylene	205-911-9	205-99-2	Carc. 1B
benzaldehyde	202-860-4	100-52-7	Acute Tox. 4
benzene	200-753-7	71-43-2	Flam. Liq. 2; Carc. 1A; Muta. 1B; STOT RE 1; Asp. Tox. 1; Eye Irrit. 2; Skin Irrit. 2
benzene-1,2,4-tricarboxylic acid 1,2-anhydride; trimellitic anhydride	209-008-0	552-30-7	STOT SE 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1	yes
benzene-1,2:4,5-tetracarboxylic dianhydride; benzene-1,2:4,5-tetracarboxylic dianhydride; pyromellitic dianhydride	201-898-9	89-32-7	Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
benzene-1,4-diamine dihydrochloride; p-phenylenediamine dihydrochloride	210-834-9	624-18-0	Acute Tox. 3; Eye Irrit. 2; Skin Sens. 1
benzenesulfonic acid, 3,3'-(methylenebis((dihydroxyphenylene)azo)) bis-, potassium sodium salt; potassium sodium 3-[(E)-(6{3,4-dihydroxy-2-}(Z)-(3-sulfonatophenyl)diazenyl]benzyl}-2,3-dihydroxyphenyl)diazenyl]benzenesulfonate HWL-158	432-590-4	243869-48-9	Eye Irrit. 2
benzidine based azo dyes; 4,4'-diarylazobiphenyl dyes, with the exception of those specified elsewhere in this Annex	-	-	Carc. 1B
benzidine; 1,1'-biphenyl-4,4'-diamine; 4,4'-diaminobiphenyl; biphenyl-4,4'-ylenediamine	202-199-1	92-87-5	Carc. 1A; Acute Tox. 4
benzo[a]pyrene; benzo[def]chrysene	200-028-5	50-32-8	Carc. 1B; Muta. 1B; Repr. 1B; Skin Sens. 1	yes
benzo[e]pyrene	205-892-7	192-97-2	Carc. 1B
Benzo[ghi]perylene	205-883-8	191-24-2		yes
benzo[j]fluoranthene	205-910-3	205-82-3	Carc. 1B
benzo[k]fluoranthene	205-916-6	207-08-9	Carc. 1B	yes
benzo[rst]pentaphene	205-877-5	189-55-9	Carc. 1B; Muta. 2
benzoic acid	200-618-2	65-85-0	STOT RE 1; Skin Irrit. 2; Eye Dam. 1
benzoic acid, N-tert-butyl-N'-(4-chlorobenzoyl)hydrazide	431-600-4	112226-61-6	Skin Sens. 1
Benzol forerunnings (coal); Light Oil Redistillate, low boiling [The distillate from coke oven light oil having an approximate distillation range below 100 o C (212 °F). Composed primarily of C4 to C6 aliphatic hydrocarbons.] The distillate from coke oven light oil having an approximate distillation range below 100°C (212°F). Composed primarily of C4 to C6 aliphatic hydrocarbons.	266-023-5	65996-88-5	Carc. 1B; Muta. 1B
benzonitrile	202-855-7	100-47-0	Acute Tox. 4
benzophenone-3,3',4,4'-tetracarboxylic dianhydride; 4,4'-carbonyldi(phthalic anhydride)	219-348-1	2421-28-5	Eye Irrit. 2; STOT SE 3
benzothiazole-2-thiol	205-736-8	149-30-4	Skin Sens. 1
benzovindiflupyr (ISO); N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	691-719-4	1072957-71-1	Acute Tox. 3
benzoyl chloride	202-710-8	98-88-4	Acute Tox. 4; Skin Corr. 1B; Skin Sens. 1
benzthiazuron (ISO); 1-benzothiazol-2-yl-3-methylurea	217-685-9	1929-88-0	Acute Tox. 4
benzyl 2,4-dibromobutanoate B2,4DBB	420-710-8	23085-60-1	Repr. 2; Skin Irrit. 2; Skin Sens. 1
benzyl [hydroxy-(4-phenylbutyl)phosphinyl] acetate SQ 28,355; SQ 28355	416-050-5	87460-09-1	Eye Dam. 1
benzyl alcohol	202-859-9	100-51-6	Acute Tox. 4
benzyl benzoate	204-402-9	120-51-4	Acute Tox. 4
benzyl chloroformate	207-925-0	501-53-1	Skin Corr. 1B
benzyl violet 4B; α-[4-(4-dimethylamino-α-{4-[ethyl(3-sodiosulphonato benzyl)amino] phenyl}benzylidene)cyclohexa-2,5-dienylidene(ethyl)ammonio]toluene-3-sulphonate	216-901-9	1694-09-3	Carc. 2
benzyl(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)pentanoylamino]-3-methylbutyrate	427-470-3	137864-22-3	Acute Tox. 4; Skin Sens. 1
benzyl-2-hydroxydodecyldi; methylammonium benzoate B 2049	402-610-6	113694-52-3	Skin Corr. 1B; Acute Tox. 4
benzyl-N-(2-(2-methoxyphenoxy)ethyl)amine hydrochloride BM 96.0258.HCL	428-290-8	120606-08-8	Acute Tox. 4; Eye Dam. 1
benzylamine	202-854-1	100-46-9	Acute Tox. 4; Skin Corr. 1B
benzyldimethylamine	203-149-1	103-83-3	Flam. Liq. 3; Acute Tox. 4; Skin Corr. 1B
benzyldimethyloctadecylammonium 3-nitrobenzenesulfonate CA10	405-330-2	124088-59-1	Skin Irrit. 2; Eye Dam. 1
benzyltributylammonium 4-hydroxynaphthalene-1-sulphonate BONTRON P-51	402-240-5	102561-46-6	Acute Tox. 4
beryllium	231-150-7	7440-41-7	Carc. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
beryllium compounds with the exception of aluminium beryllium silicates, and with those specified elsewhere in this Annex show/hide Nitric acid, beryllium salt, tetrahydrate EC / List no: 690-699-4 \| CAS no: 13510-48-0 Beryllium selenide EC / List no: 235-450-9 \| CAS no: 12232-25-6 Octadecanoic acid, beryllium salt EC / List no: - \| CAS no: 16687-38-0 Beryllium orthosilicate EC / List no: 239-251-8 \| CAS no: 15191-85-2 Beryllium acetylide EC / List no: 208-050-7 \| CAS no: 506-66-1 Zinc beryllium silicate EC / List no: - \| CAS no: 39413-47-3 Beryllium dibromide EC / List no: 232-115-9 \| CAS no: 7787-46-4 Beryllium sulphate EC / List no: 236-842-2 \| CAS no: 13510-49-1 Aluminium alloy, Al,Be EC / List no: 603-236-8 \| CAS no: 12770-50-2 Beryllium nitrate EC / List no: 237-062-5 \| CAS no: 13597-99-4 Steel manufacture, chemicals This category includes the chemical substances which are manufactured as part of steel and alloy steels. The following list identifies those elements which may exist in steel or which may comprise compounds present in steel or alloy steels. Aluminum, beryllium, boron, calcium, carbon, cerium, chromium, cobalt, copper, hafnium, iron, lanthanum, lead, magnesium, manganese, molybdenum, nickel, niobium, nitrogen, oxygen, phosphorus, selenium, silicon, sulfur, tantalum, tin, titanium, tungsten, vanadium, yttrium, zinc, zirconium. EC / List no: 266-048-1 \| CAS no: 65997-19-5 Phosphoric acid, beryllium salt (2:3) EC / List no: - \| CAS no: 13598-26-0 Beryllium diammonium tetrafluoride EC / List no: 238-948-4 \| CAS no: 14874-86-3 Beryllium hydrogen phosphate (1:1) EC / List no: - \| CAS no: 13598-15-7 Beryllium zinc silicate EC / List no: 247-151-0 \| CAS no: 25638-88-4 Beryllium, bis(carbonato(2-))dihydroxytri- EC / List no: - \| CAS no: 66104-24-3 Diethylberyllium EC / List no: 208-823-9 \| CAS no: 542-63-2 Beryllium phosphide EC / List no: 261-137-1 \| CAS no: 58127-61-0 Disodium tetrafluoroberyllate EC / List no: 237-630-2 \| CAS no: 13871-27-7 Beryllium hydroxide EC / List no: 236-368-6 \| CAS no: 13327-32-7 Bertrandite (Be4(OH)2O(SiO3)2) EC / List no: 235-299-9 \| CAS no: 12161-82-9 Beryllium diboride EC / List no: 235-694-6 \| CAS no: 12536-51-5 Beryllium carbonate EC / List no: 236-030-8 \| CAS no: 13106-47-3 Tetraberyllium boride EC / List no: 235-695-1 \| CAS no: 12536-52-6 Beryllium phosphide (BeP2) EC / List no: - \| CAS no: 1268721-56-7 Beryllium hexaboride EC / List no: 235-657-4 \| CAS no: 12429-94-6 Beryllium diboride EC / List no: 235-443-0 \| CAS no: 12228-40-9 Beryllium sulfate tetrahydrate EC / List no: 629-461-1 \| CAS no: 7787-56-6 Beryllium EC / List no: 231-150-7 \| CAS no: 7440-41-7 Beryllium sulphide EC / List no: 237-064-6 \| CAS no: 13598-22-6 Silicic acid, beryllium salt EC / List no: 261-293-0 \| CAS no: 58500-38-2 Beryllium fluoride EC / List no: 232-118-5 \| CAS no: 7787-49-7 Beryllium diiodide EC / List no: 232-119-0 \| CAS no: 7787-53-3 Triberyllium nitride EC / List no: 215-132-6 \| CAS no: 1304-54-7 Bis(pentane-2,4-dionato-O,O')beryllium EC / List no: 233-513-5 \| CAS no: 10210-64-7 Beryllium chloride EC / List no: 232-116-4 \| CAS no: 7787-47-5 Hexakis[μ-(acetato-O:O')]-μ4-oxotetraberyllium EC / List no: 242-785-4 \| CAS no: 19049-40-2 Phosphoric acid, beryllium salt EC / List no: 252-356-3 \| CAS no: 35089-00-0 Beryllium oxyfluoride EC / List no: - \| CAS no: 63990-88-5 Beryllium telluride EC / List no: 235-451-4 \| CAS no: 12232-27-8 Beryllium di(acetate) EC / List no: 208-850-6 \| CAS no: 543-81-7 Beryllium nitrate trihydrate EC / List no: - \| CAS no: 7787-55-5 Copper alloy, Cu 96, Be 2.2-2.8, Ni 1.1 (CDA 827) EC / List no: - \| CAS no: 11108-64-8	-	-	Carc. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
beryllium oxide	215-133-1	1304-56-9	Carc. 1B; Acute Tox. 2; Acute Tox. 3; STOT RE 1; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
Beta-hexabromocyclododecane	603-802-4	134237-51-7		yes

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EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

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Last updated 23 April 2024. Database contains 4753 unique substances/entries.

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