EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Last updated 19 April 2024. Database contains 4753 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
EU REACH: List of SVHC
di-methylamine;di-methylamine ... %
204-697-4
124-40-3
Flam. Gas 1; Press. Gas; Acute Tox. 4; STOT SE 3; Skin Irrit. 2; Eye Dam. 1
di-methylamine;di-methylamine ... %
204-697-4
124-40-3
Flam. Liq. 1; Acute Tox. 4; Skin Corr. 1B
di-n-butyl ether; dibutyl ether
205-575-3
142-96-1
Flam. Liq. 3; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2
di-n-butylamine
203-921-8
111-92-2
Flam. Liq. 3; Acute Tox. 4
di-n-octylaluminium iodide
DNOAI
408-190-0
7585-14-0
Pyr. Liq. 1; Skin Corr. 1B
di-sec-butylamine
210-937-9
626-23-3
Flam. Liq. 3; Acute Tox. 4
di-tert-(C12-14)-alkylammonium 2-benzothiazolylthiosuccinate
CM 26-137
406-052-4
125078-60-6
Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
di-tert-butyl peroxide
203-733-6
110-05-4
Org. Perox. E; Flam. Liq. 2; Muta. 2
dialifos (ISO); 2-chloro-1-phthalimidoethyl O,O-diethyl phosphorodithioate
233-689-3
10311-84-9
Acute Tox. 2; Acute Tox. 3
diallyl phthalate
205-016-3
131-17-9
Acute Tox. 4
dialuminium nickel tetraoxide
234-454-8
12004-35-2
Carc. 1A; STOT RE 1; Skin Sens. 1
diamminediisocyanatozinc
GENIPLEX A
401-610-3
122012-52-6
Acute Tox. 4; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diammonium 1-hydroxy-2-(4-(4-carboxyphenylazo)-2,5-dimethoxyphenylazo)-7-amino-3-naphthalenesulfonate
422-670-7
150202-11-2
Repr. 2; Acute Tox. 3; STOT RE 2
diammonium hexachloroplatinate
240-973-0
16919-58-7
Acute Tox. 3; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diammonium nickel bis(sulfate)
239-793-5
15699-18-0
Carc. 1A; Muta. 2; Repr. 1B; STOT RE 1; Acute Tox. 4; Resp. Sens. 1; Skin Sens. 1
diammonium nickel hexacyanoferrate
-
74195-78-1
Carc. 1A; STOT RE 1; Resp. Sens. 1; Skin Sens. 1
diammonium peroxodisulphate; ammonium persulphate
231-786-5
7727-54-0
Ox. Sol. 3; Acute Tox. 4; Eye Irrit. 2; STOT SE 3; Skin Irrit. 2; Resp. Sens. 1; Skin Sens. 1
diammonium tetrachloroplatinate
237-499-1
13820-41-2
Acute Tox. 3; Skin Irrit. 2; Eye Dam. 1; Resp. Sens. 1; Skin Sens. 1
diazinon (ISO); O,O-diethyl O-2-isopropyl-6-methylpyrimidin-4-yl phosphorothioate
206-373-8
333-41-5
Acute Tox. 4
diazomethane
206-382-7
334-88-3
Carc. 1B
dibenz[a,h]anthracene
200-181-8
53-70-3
Carc. 1B
dibenzo[b,def]chrysene; dibenzo[a,h]pyrene
205-878-0
189-64-0
Carc. 1B; Muta. 2
dibenzo[def,p]chrysene; dibenzo[a,l]pyrene
205-886-4
191-30-0
Carc. 1B; Muta. 2
dibenzoyl peroxide; benzoyl peroxide
202-327-6
94-36-0
Org. Perox. B; Eye Irrit. 2; Skin Sens. 1
dibenzylphenylsulfonium hexafluoroantimonate
ZK RT 1507
417-760-8
134164-24-2
STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
dibromomethane
200-824-2
74-95-3
Acute Tox. 4
dibutyl-3-(4-(5-ammonio-2-butyl)benzofuran-3-yl)carbonyl)phenoxy)propyl ammonium oxalate; (5-amino-2-butylbenzofuran-3-yl) [4-(3-dibutylaminopropoxy)phenyl]methanone, dioxalate
AMINODARONE OXALATE; SR33580A
448-700-9
500791-70-8
STOT RE 2; Eye Dam. 1; Skin Sens. 1
dibutyltin dilaurate; dibutyl[bis(dodecanoyloxy)] stannane
201-039-8
77-58-7
Muta. 2; Repr. 1B; STOT RE 1
dibutyltin hydrogen borate
DBB
401-040-5
75113-37-0
Repr. 1B; Muta. 2; STOT RE 1; Acute Tox. 4; Eye Dam. 1; Skin Sens. 1
dicamba (ISO); 2,5-dichloro-6-methoxybenzoic acid; 3,6-dichloro-2-methoxybenzoic acid
217-635-6
1918-00-9
Acute Tox. 4; Eye Dam. 1
dichlobenil (ISO); 2,6-dichlorobenzonitrile
214-787-5
1194-65-6
Acute Tox. 4
dichlofenthion (ISO); O—2,4-dichlorophenyl O,O-diethyl phosphorothioate
202-564-5
97-17-6
Acute Tox. 4
dichlofluanid (ISO); N-dichlorofluoromethylthio-N',N'-dimethyl-N-phenylsulfamide
214-118-7
1085-98-9
Acute Tox. 4; Eye Irrit. 2; Skin Sens. 1
dichlone (ISO); 2,3-dichloro-1,4-naphthoquinone
204-210-5
117-80-6
Acute Tox. 4; Eye Irrit. 2; Skin Irrit. 2
dichloro-(3-(3-chloro-4-fluorophenyl)propyl)methylsilane
SILAN DCS
407-180-3
770722-36-6
Skin Corr. 1A
dichloro-1,3,5-triazinetrione; dichloroisocyanuric acid
220-487-5
2782-57-2
Ox. Sol. 2; Acute Tox. 4; Eye Irrit. 2; STOT SE 3
dichloroacetic acid
201-207-0
79-43-6
Skin Corr. 1A
dichloroacetyl chloride
201-199-9
79-36-7
Skin Corr. 1A
dichloroacetylene
620-404-6
7572-29-4
Unst. Expl.; Carc. 2; STOT RE 2
dichlorodioctyl stannane
222-583-2
3542-36-7
Repr. 1B; Acute Tox. 2; STOT RE 1
dichloromethane; methylene chloride
200-838-9
75-09-2
Carc. 2
dichlorophen (ISO)
202-567-1
97-23-4
Acute Tox. 4; Eye Irrit. 2
dichlorprop (ISO); 2-(2,4-dichlorophenoxy)propionic acid
204-390-5
120-36-5
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1
dichlorprop-P (ISO); (+)-R-2-(2,4-dichlorophenoxy)propionic acid
D-2,4-DP; DICHLORPROP-P; DUPLOSAN DP-ACID
403-980-1
15165-67-0
Acute Tox. 4; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1
dichlorvos (ISO); 2,2-dichlorovinyl dimethyl phosphate
200-547-7
62-73-7
Acute Tox. 2; Acute Tox. 3; Skin Sens. 1
diclobutrazole (ISO);(R*, R*)-(±)-β-[(2,4-dichlorop henyl)methyl]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; (2RS, 3RS)-1-(2,4-dichlorophenyl)-4,4-dimethyl-2- (1H—1,2,4-triazol-1yl)pentan-3-ol
620-436-0
75736-33-3
Eye Irrit. 2
diclofop-methyl (ISO)methyl 2-(4-(2,4-dichlorophenoxy)phenoxy)propionate; methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate
257-141-8
51338-27-3
Acute Tox. 4; Skin Sens. 1
dicofol (ISO); 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol
204-082-0
115-32-2
Acute Tox. 4; Skin Irrit. 2; Skin Sens. 1
dicopper chloride trihydroxide
215-572-9
1332-65-6
Acute Tox. 4; Acute Tox. 3
dicopper oxide; copper (I) oxide
215-270-7
1317-39-1
Acute Tox. 4; Eye Dam. 1
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