EU-IMPLANTABLE_MEDICAL_DEVICES-ART_3_ANX_1

Active Implantable Medical Devices Directive - Hazardous Substances

EU. Hazardous Substances for Purposes of Directive 90/385/EEC on Active Implantable Medical Devices, 20 July 1990, amended by Directive 2007/47/EC, 21 September 2007

This list contains hazardous substances for purposes of Directive 90/385/EEC on active implantable medical devices, particularly as regards Article 3 and Annex I (Essential Requirements). This non-exhaustive database is derived from: Table 3 of Annex VI to CLP, REACH Candidate List of SVHCs, and Directive 2000/54/EC's Annex III (Biological Agents list). Please note that Regulation (EU) 2017/745 on medical devices has repealed Directive 90/385/EEC and begun to apply from 26 May 2021. Nevertheless, Article 120 of the Regulation provides for a transitional period allowing medical devices, under specified conditions (e.g., placed on the market prior to 26 May 2021), to continue to comply with the Directive. In accordance with the fourth paragraph of Article 120, this period ends 26 May 2025.

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Last updated 24 April 2024. Database contains 4753 unique substances/entries.
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Substance Name
EC No.
CAS No.
EU CLP (1272/2008)
EU_BA Directive 2000/54/EC
EU REACH: List of SVHC
glyphosate-trimesium; glyphosate-trimethylsulfonium
617-243-9
81591-81-3
Acute Tox. 4
guanidinium benzoate
GUANIDINIUMBENZOAT
429-820-0
26739-54-8
Acute Tox. 4
haloxyfop-etotyl (ISO); 2-ethoxyethyl 2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate; haloxyfop-(2-ethoxyethyl)
HALOXYFOP ETHOXYETHYL EST
402-560-5
87237-48-7
Acute Tox. 4
hexachloroacetone
204-129-5
116-16-5
Acute Tox. 4
hexan-1-ol
203-852-3
111-27-3
Acute Tox. 4
hexapentyldistannoxane
247-143-7
25637-27-8
Acute Tox. 4
hydroxo(2-(benzenesulfonamido)benzoato)zinc(II)
SICORIN E 10197
403-750-0
113036-91-2
Acute Tox. 4
imidacloprid (ISO); 1-(6-chloropyridin-3-ylmethyl)-N-nitroimidazolidin-2-ylidenamine
428-040-8
138261-41-3
Acute Tox. 4
iodine
231-442-4
7553-56-2
Acute Tox. 4
iprobenfos(ISO); S-benzyl diisopropyl phosphorothioate
247-449-0
26087-47-8
Acute Tox. 4
isobutyl 2-(4-(4-chlorophenoxy)phenoxy)propionate; clofop-isobutyl (ISO)
-
51337-71-4
Acute Tox. 4
isobutyric acid
201-195-7
79-31-2
Acute Tox. 4
isoprocarb (ISO); 2-isopropylphenyl N-methylcarbamate
220-114-6
2631-40-5
Acute Tox. 4
manganese dioxide
215-202-6
1313-13-9
Acute Tox. 4
MCPA-thioethyl (ISO); S-ethyl (4-chloro-2-methylphenoxy)ethanethioate; S-ethyl 4-chloro-o-tolyloxythioacetate
246-831-4
25319-90-8
Acute Tox. 4
menazon (ISO); S-[(4,6-diamino-1,3,5-triazin-2-yl)methyl] O, O-dimethyl phosphorodithioate
201-123-4
78-57-9
Acute Tox. 4
metal salts of thiocyanic acid, with the exception of those specified elsewhere in this Annex
-
-
Acute Tox. 4
metamitron (ISO);4-amino-3-methyl-6-phenyl-1,2,4-triazin-5-one
255-349-3
41394-05-2
Acute Tox. 4
methyl (R)-2-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenoxy)propionate
HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
406-250-0
72619-32-0
Acute Tox. 4
methyl 3,4-dichlorophenylcarbanilate; SWEP.
620-362-9
1918-18-9
Acute Tox. 4
methyl 3-(3-tert-butyl-4-hydroxy-5-methylphenyl)propionate
G 18-1108
403-270-1
6386-39-6
Acute Tox. 4
methyl [2-(1,1-dimethylethyl)-6-methoxypyrimidin-4-yl]ethylphosphonothioate
MAT 9460
414-080-3
117291-73-3
Acute Tox. 4
methyl neodecanamide
414-460-9
105726-67-8
Acute Tox. 4
metolcarb (ISO); m-tolyl methylcarbamate; MTMC
214-446-0
1129-41-5
Acute Tox. 4
metribuzin (ISO); 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one; 4-amino-4,5-dihydro-6-(1,1-dimethylethyl)-3-methylthio-1,2,4-triazin-5-one
244-209-7
21087-64-9
Acute Tox. 4
milbemectin (ISO) [reaction mass of milbemycin A3 (CAS No 51596-10-2) and milbemycin A4 (CAS No 51596-11-3) (30:70)]
-
-
Acute Tox. 4
N, N,N',N'-tetramethyl-p-phenylenediamine
202-831-6
100-22-1
Acute Tox. 4
N,N'-dimethylbenzidine
-
2810-74-4
Acute Tox. 4
N-(2',6'-dimethylphenyl)-2-piperidinecarboxamide hydrochloride
PPX-HCL
417-950-0
65797-42-4
Acute Tox. 4
N-(2,2,6,6-tetramethyl-1-oxylpiperidin-4-yl)acetamide; (4-acetamido-2,2,6,6-tetra; methyl-1-piperidinyl)oxidanyl
423-840-3
14691-89-5
Acute Tox. 4
N-ethyl-N-methylpiperidinium iodide
CATALYST 4017
407-780-5
4186-71-4
Acute Tox. 4
naptalam-sodium (ISO); sodium N-naphth-1-ylphthalamate
205-073-4
132-67-2
Acute Tox. 4
nitrapyrin (ISO); 2-chloro-6-trichloromethylpyridine
217-682-2
1929-82-4
Acute Tox. 4
norbormide (ISO); 5-(α-hydroxy-α-2-pyridylbenzyl)-7-(α-2-pyridylbenzylidene)bicycle [2.2.1] hept-5-ene-2,3-dicarboximide
213-589-6
991-42-4
Acute Tox. 4
noruron (ISO); 1,1-dimethyl-3-(perhydro-4,7-methanoinden-5-yl)urea
-
2163-79-3
Acute Tox. 4
O,O,O',O'-tetrapropyl dithiopyrophosphate
221-817-0
3244-90-4
Acute Tox. 4
oxalic acid
205-634-3
144-62-7
Acute Tox. 4
oxycarboxin (ISO); 2,3-dihydro-6-methyl-5-(N-phenylcarbamoyl)-1,4-oxothiine 4,4-dioxide
226-066-2
5259-88-1
Acute Tox. 4
papaverine
200-397-2
58-74-2
Acute Tox. 4
pebulate (ISO); N-butyl-N-ethyl-S-propylthiocarbamate
214-215-4
1114-71-2
Acute Tox. 4
phenthoate (ISO); ethyl 2-(dimethoxyphosphinothioylthio)-2-phenylacetate
219-997-0
2597-03-7
Acute Tox. 4
phosnichlor (ISO); O-4-chloro-3-nitrophenyl O, O-dimethyl phosphorothioate
-
5826-76-6
Acute Tox. 4
piperophos (ISO); S-2-methylpiperidinocarbonylmethyl-O, O-dipropyl phosphorodithioate
607-329-4
24151-93-7
Acute Tox. 4
potassium bis(N-carboxymethyl)-N-methyl-glycinato-(2-)N, O,O, N)-ferrate-(1-)monohydrate
CHEMICAL CHELATING AGENT #2
411-640-9
153352-59-1
Acute Tox. 4
potassium cyanate
209-676-3
590-28-3
Acute Tox. 4
prochloraz (ISO);N-propyl-N-[2-(2,4,6-trichlorop henoxy)ethyl]-1H-imidazole-1- carboxamide
266-994-5
67747-09-5
Acute Tox. 4
profenofos (ISO)O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate
255-255-2
41198-08-7
Acute Tox. 4
propanil (ISO); 3',4'-dichloropropionanilide
211-914-6
709-98-8
Acute Tox. 4
prosulfuron (ISO); 1-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-3-[2-(3,3,3-trifluoropropyl)phenylsulfonyl]urea
619-000-2
94125-34-5
Acute Tox. 4
pyrazophos (ISO); O, O-diethyl O-(6-ethoxycarbonyl-5-methylpyrazolo[2,3-a]pyrimidin-2-yl) phosphorothioate
236-656-1
13457-18-6
Acute Tox. 4
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