Endocrine disruptor assessment list

Endocrine disruptor assessment list

Endocrine disruptor assessment list

ECHA’s endocrine disruptor (ED) assessment list includes the substances undergoing an ED assessment that have been brought for discussion to ECHA’s ED Expert Group.

Explanatory note

Inclusion in the list means that an informal hazard assessment for endocrine-disrupting properties either is under development or has been completed since February 2013.

For each substance, the table shows the assessing or evaluating Member State (submitter), the outcome from the assessment, and the date of the latest update to the list entry.

Other process details and hazard assessment outcome documents are also available and can be accessed through the ‘Details’ icon.

One possible outcome of such an assessment is that a substance is considered not to have ED properties.

If the outcome is that the substance is considered to have ED properties, confirmation through the formal risk management and decision-making processes under is needed before any regulatory action can be taken due to these properties.

The intentions of authorities to submit a dossier to the formal REACH and CLP processes are notified through the Registry of Intentions. All biocidal active substances have to undergo a formal ED assessment. You can see the status of biocides assessments on the Biocidal Active Substances page.


The information and views set out in the ED assessment list and in the hazard assessment outcome documents are those of the evaluating authority and do not necessarily reflect the position or opinion of the other Member States or ECHA. Neither ECHA nor the evaluating authority nor any person acting on either of their behalves may be held liable for the use, which may be made of the information contained therein. Statements made or information contained in the documents are without prejudice to any formal regulatory activities that ECHA or the Member States may initiate at a later stage. ED assessments and their outcomes are compiled on the basis of information available by the date of the publication of the document.

tert-butyl methyl ether

EC / List no: 216-653-1 CAS no: 1634-04-4
Endocrine disruption
Date of intention
Date of hazard assessment
Hazard assessment outcome document
According to the substance evaluation conclusion document.

ED environment: even if an estrogenic activity was observed in male fish (vitellogenin induction), there were no adverse effects observed in vivo. In the absence of adverse effects, endocrine disruption cannot be demonstrated for fish.

ED human health: based on the data evaluated during SEv, ED related effects could only be seen at very high doses (effects at doses above the limit dose, 1000 mg/kg bw/d) and without a consistent mode of action. The concern was not sufficient to request further testing.

ED properties of MTBE for human health may require further consideration based on new data and will be re-assessed by the endocrine disruptors working group of ANSES and discussed in an upcoming RMOA.
Submitter organisation
Ministry of Ecology, Sustainable Development and Energy
Submitter email
Submitter phone
Submitter address
Ministry of Ecology, Sustainable Development and Energy MEDDE - 92055 - La Defense cedex
Latest update
First published