Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
403-240-8
CAS no.:
106264-79-3
Index number:
612-113-00-8
Molecular formula:
SMILES:
InChI:
Type of substance:
Multi constituent substance
Origin:
Organic
Registered compositions:
7
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is very toxic to aquatic life, is very toxic to aquatic life with long lasting effects, is harmful if swallowed and may cause an allergic skin reaction.

Breakdown of all 155 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Aquatic Acute 1 H400 Harmonised Classification
Aquatic Chronic 1 H410 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa-term.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa-term.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa-term.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 5 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

This substance is used in the following products: coating products.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: adhesives and sealants, coating products and polymers.

This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: non-industrial spraying, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of chemicals at non-dedicated facilities, roller or brushing applications, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following products: polymers, adhesives and sealants and coating products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: polymers, adhesives and sealants and coating products.

This substance is used in the following areas: building & construction work. This substance is used for the manufacture of: plastic products and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, industrial spraying, transfer of substance into small containers and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: for thermoplastic manufacture and as an intermediate step in further manufacturing of another substance (use of intermediates).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ALBEMARLE, Parc Scientifique Einstein Rue du Bosquet, 9 1348 Louvain-La-Neuve Belgium
  • ALBEMARLE EUROPE SPRL, Parc Scientifique (Einstein) Rue du Bosquet 9 1348 LOUVAIN-LA-NEUVE Belgium
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • YOU Solutions Germany GmbH - REACH (part of Arxada), Freundallee 9 a 30173 Hannover Germany
  • DKSH Great Britain Ltd., 32 Threadneedle Street EC2R 8AY London United Kingdom
  • PAGLIARA PRODOTTI CHIMICI SPA, Via Don Comotti, 7 24050 Lurano (BG) BG Italy

Substance names and other identifiers

1,3-Benzenediamine, 2(or 4)-methyl-4,6(or 2,6)-bis(methylthio)-
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Other
1,3-Benzenediamine, 4,6(or 2,6)-bis(methylthio)-2(or 4)-methyl-
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Other
3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine-(mixture)
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Other
4,6(or 2,6)-Bis(methylthio)-2(or 4)-methyl-1,3-benzenediamine
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Other
6-methyl-2,4-bis(methylthio)phenylene-1,3-diamine
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
C&L Inventory, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
EC Inventory, Other
A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
REACH pre-registration, Other
bis(methylsulfanyl)(methyl)benzene-1,3-diamine
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Other
Ethacure 300
DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Other
4-metyl-2,6-bis(metylsulfanyl)benzén-1,3-diamín (sk)
C&L Inventory
6-methyl-2,4-bis(methylsulfanyl)benzen-1,3-diamin (cs)
C&L Inventory
6-methyl-2,4-bis(methylthio)fenyleen-1,3-diamine (nl)
C&L Inventory
6-methyl-2,4-bis(methylthio)phenylen-1,3-diamin (da)
C&L Inventory
6-Methyl-2,4-bis(methylthio)phenylen-1,3-diamin (de)
C&L Inventory
6-metil-2,4-bis(metiltio)fenilen-1,3-diamin (hr)
C&L Inventory
6-metil-2,4-bis(metiltio)fenilen-1,3-diamin (sl)
C&L Inventory
6-metil-2,4-bis(metiltio)fenilen-1,3-diamina (ro)
C&L Inventory
6-metil-2,4-bis(metiltio)fenilen-1,3-diaminas (lt)
C&L Inventory
6-metil-2,4-bis(metiltio)fenilen-1,3-diammina (it)
C&L Inventory
6-metil-2,4-bis(metiltio)fenileno-1,3-diamina (es)
C&L Inventory
6-metil-2,4-bis(metiltio)fenileno-1,3-diamina (pt)
C&L Inventory
6-metil-2,4-bisz(metiltio)fenilén-1,3-diamin (hu)
C&L Inventory
6-metyl-2,4-bis(metyltio)fenylen-1,3-diamin (no)
C&L Inventory
6-metyl-2,4-bis(metyltio)fenylen-1,3-diamin (sv)
C&L Inventory
6-metylo-2,4-bis(metylosulfanylo)fenyleno-1,3-diamina 6-metylo-2,4-bis(metylotio)fenyleno-1,3-diamina (pl)
C&L Inventory
6-Metyyli-2,4-bis(metyylitio)fenyleeni-1,3-diamiini (fi)
C&L Inventory
6-Metüül-2,4-bis(metüültio)fenüleen-1,3-diamiin (et)
C&L Inventory
6-méthyl-2,4-bis(méthylthio)phénylène-1,3-diamine (fr)
C&L Inventory
6-μεθυλo-2,4-δις(μεθυλoθειo)φαινυλενo-1,3-διαμίν (el)
C&L Inventory
6-мeтил-2,4-бис(метилтио)фенилен-1,3-диамин (bg)
C&L Inventory
1,3-Benzenediamine, 2(or 4)-methyl-4,6(or 2,6)-bis(methylthio)-
C&L Inventory
2-Methyl-4,6-bis(methylsulfanyl)benzene-1,3-diamine
C&L Inventory
21 AZ 76
Registration dossier
3,5-Dimethylthio-2,4-(or 2,6-)toluenediamine
Registration dossier
3,5-Dimethylthio-2,4-toluenediamine
C&L Inventory
3,5-dimethylthio-2,4-toluenediamine 3,5-dimethylthio-2,6-toluenediamine
C&L Inventory
6-methyl-2,4-bis(methylthio)phenylene-1,3-diamine
C&L Inventory
A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
C&L Inventory, Registration dossier
Di-methylthio diamono tholuene
C&L Inventory
DMTDA
Registration dossier
Reaction mass of 3,5-dimethylthio-2,4-toluenediamine and 3,5-dimethylthio-2,6-toluenediamine
Registration dossier, Other
reaction mass of: 3,5-dimethylthio-2,4-toluenediamine 3,5-dimethylthio-2,6-toluenediamine
Registration dossier
reaction mass of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
C&L Inventory
reaction mass of:3,5-dimethylthio-2,4-toluenediamine3,5-dimethylthio-2,6-toluenediamine
Registration dossier
reaction mixture of 3,5-dimethylthio-2,4-toluenediamine and 3,5-dimethylthio-2,6-toluenediamine
Registration dossier
Unknown
C&L Inventory
21 AZ 76
Registration dossier
DM-C-TDA
Registration dossier
DMTDA
Registration dossier
ETHACURE (R) 300 CURATIVE
Registration dossier
ETHACURE(R) 300 CURATIVE
Registration dossier
106264-79-3
CAS number
C&L Inventory, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
612-113-00-8
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Odour
Other (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
-20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-42 °C

Boiling point

Study results
  • 4 studies submitted
  • 2 studies processed
R Boiling point
225 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
225 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Relative density
1.05 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.05

Vapour pressure

Study results
  • 4 studies submitted
  • 2 studies processed
R Vapour pressure
10 Pa @ 20 - 25 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
10 Pa @ 25 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 2 studies processed
R Log Pow
2.37 - 2.895 @ 20 °C and pH 9 [5]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
2.5 @ 20 °C

Water solubility

Study results
  • 4 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
162 - 298 mg/L @ 20 °C [4]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
162 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Surface tension

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 5 studies submitted
  • 2 studies processed
R Flash point
176 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
176 °C

Auto flammability

Study results
  • 4 studies submitted
  • 2 studies processed
R Autoflammability / self-ignition
400 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
400 °C

Flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 1 study processed
C Interpretation of results
Not readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 6
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 8.7 µg/L (2)
Intermittent releases (freshwater) 11 µg/L (2)
Marine water 870 ng/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 3.2 mg/L (2)
Sediment (freshwater) 200 µg/kg sediment dw (2)
Sediment (marine water) 20 µg/kg sediment dw (2)
Hazard for Air
Air -
Hazard for Terrestrial Organism
Soil 160 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 3.3 mg/kg food (2)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
LC50 (4 days) 16.9 mg/L [1]
LC50 (72 h) 17.8 mg/L [1]
LC50 (48 h) 22.5 mg/L [1]
LC50 (24 h) 42.3 mg/L [1]
LC100 (4 days) 32 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 900 µg/L [2]
EC50 (24 h) 1.1 mg/L [2]
LC50 (48 h) 1.1 mg/L [1]
EC100 (48 h) 4 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 3.3 - 7.6 mg/L [3]
NOEC (72 h) 1.9 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
7.6 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.4 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 11.8 mg/m³ -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 390 µg/kg bw/day repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
EYE Exposure
-
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 940 µg/m³ repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 240 µg/kg bw/day repeated dose toxicity
Acute /short term: - -
Local Effects
Long-term: - -
Acute /short term: - -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 240 µg/kg bw/day repeated dose toxicity
Acute /short term: - -
EYE Exposure
-

Toxicokinetics, metabolism, and distribution

Data not provided by the registrant

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 1 515 mg/kg bw (rat) [2]
M/CInterpretations of results
Category 4 based on GHS criteria [1]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
inhalation
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other 1 2
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 515 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other 5
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Genetic toxicity

Study results
Study data: in vitro
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 18
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Data not provided by the registrant

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant