Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
203-396-5
CAS no.:
106-42-3
Index number:
601-022-00-9
Molecular formula:
C8H10
SMILES:
CC1=CC=C(C)C=C1
InChI:
InChI=1S/C8H10/c1-7-3-5-8(2)6-4-7/h3-6H,1-2H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
22
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is a flammable liquid and vapour, is harmful in contact with skin, is harmful if inhaled and causes skin irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may be fatal if swallowed and enters airways, causes serious eye irritation, is harmful to aquatic life with long lasting effects and may cause respiratory irritation.

Breakdown of all 1357 C&L notifications submitted to ECHA

Flam. Liq. 3 H226 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Acute Tox. 4 H312 Harmonised Classification
Eye Irrit. 2 H319
STOT SE 3 H335
Asp. Tox. 1 H304
Aquatic Chronic 3 H412
STOT RE 2 H373
Aquatic Chronic 2 H411
Repr. 1B H360
Acute Tox. 4 H302
STOT SE 2 H371
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa-term.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa-term.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa-term.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 28 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: anti-freeze products, lubricants and greases and biocides (e.g. disinfectants, pest control products).

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: laboratory chemicals, coating products, fuels, plant protection products, washing & cleaning products and oil and gas exploration or production products.

This substance is used in the following areas: offshore mining.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, non-industrial spraying and roller or brushing applications.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and in processing aids at industrial sites.

This substance is used in the following products: laboratory chemicals, coating products, fuels, washing & cleaning products and oil and gas exploration or production products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: offshore mining. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and as processing aid.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; avoid release to the environment; avoid breathing the dust, fume, gas, mist, vapours or spray; take actions to prevent static discharges; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. Do not induce vomiting. If skin irritation occurs: Get medical advice/attention.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • B-Lands Consulting (8111117-5), World Trade Center, 5 Place Robert Schuman - BP1510 38025 Grenoble France France
  • Braskem Netherlands B.V., Weena 00240, C 9th floor NL - 3012 NJ PO Box 30128 3001 DC Rotterdam Netherlands
  • Chemical Standards SIA, Ritausma 31 LV-2127 Medemciems Olaine parish Latvia
  • COMPANÍA ESPAÑOLA DE PETRÓLEOS, S.A (CEPSA), Torre Cepsa, Paseo de la Castellana 259A 28046 Madrid Spain
  • EcoMole sro, U Vetrniku 40/1 16200 Praha 6-Břevnov Czech Republic
  • ExxonMobil Chemical Holland B.V., Botlekweg, 121, Haven nr 40-60 NL 3197 KA Botlek Rotterdam Netherlands
  • ExxonMobil Petroleum & Chemical BV, Polderdijkweg 2030 Antwerpen Belgium
  • Global Product Compliance (Europe) AB, IDEON, Beta 5, Scheelevägen 17, 22363 Lund Sweden
  • Indorama Ventures Portugal PTA, Unipessoal Lda, ZILS, Zona 2, Lote 2E1, Monte Feio 7520-064 Sines Portugal
  • INDORAMA VENTURES QUÍMICA S.L.U., Polígono Industrial Guadarranque, 0, sin número 11360 San Roque Cádiz Spain
  • Ineos Aromatics Belgium NV, Amocolaan 2 2440 Geel Belgium
  • INEOS Aromatics Limited, Amocolaan 2 2440 Geel Belgium
  • Intertek Deutschland GmbH 71, Stangenstrasse 1 70771 Leinfelden- Echterdingen Germany
  • OQ Chemicals GmbH OR AROM, Rheinpromenade 4a 40789 Monheim am Rhein Germany
  • OQEMA Contract GmbH, OR1, Nauheimer Strasse 37 70372 Stuttgart Germany
  • PCK RAFFINERIE GMBH, Passower Chaussee 111 16303 Schwedt/Oder Germany
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland Poland
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • REACHLaw Ltd., Aleksanterinkatu 19 00100 Helsinki Finland
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • Shell Chemicals Europe B.V., Weena 505 3013 AL Rotterdam Netherlands Netherlands
  • Shell Deutschland GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany
  • Shell Trading Rotterdam B. V., Weena 505 3013 AL Rotterdam Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • TotalEnergies Raffinage France, 2, place Jean Millier, La Défense 92400 Courbevoie France
  • TotalEnergies Trading Europe, 2 Place Jean Millier La Défense 6 92400 Courbevoie France
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (054), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • Covance Clinical Development SA 035, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Globalsky Inc Ltd, 301 Blackburn Road BL1 8HB Bolton Lancashire United Kingdom
  • HML Europe BV, De Haal 82 1511 AT Oostzaan Netherlands
  • Honeywell Specialty Chemicals Seelze GmbH, Wunstorfer Str. 40 30926 Seelze Deutschland Germany
  • Intertek Semko AB 20, Torshamnsgatan 43 SE-16422 Kista Sweden
  • IVICT Europe GmbH, Kennedydamm 19 40476 Düsseldorf Germany
  • Koole Tankstorage Botlek B.V., Oude Maasweg 6 3197 KJ Rotterdam Netherlands
  • Petrochemical Commercial Company (UK) Ltd, 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom
  • Petróleos de Portugal - Petrogal, S.A., Rua Tomás da Fonseca, Torres de Lisboa, Torre C 1600-209 Lisboa Portugal
  • Tricon Energy Iberica, S.L.U., Avenida Pau Casals, nº 14, 6º piso, 08021 Barcelona Spain
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy

Substance names and other identifiers

1,4-Dimethylbenzene
Other
4-Xylene
Other
Benzene, 1,4-dimethyl-
Other
Chromar
Other
p-Dimethylbenzene
Other
p-Methyltoluene
Other
p-xylene
EC Inventory, Substance Evaluation - CoRAP, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 1st list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
p-Xylene
Substance Evaluation - CoRAP, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Ambient Air Quality Directive, Annex X - Ozone Precursor Substances, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 1st list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
p-Xylol
Other
Scintillar
Other
p-ksilen (sl)
C&L Inventory
p-xilen (ro)
C&L Inventory
p-xilol (hu)
C&L Inventory
π-ξυλόλιο (el)
C&L Inventory
Ρ-ksilenas (lt)
C&L Inventory
1, 4-Dimethylbenzen
C&L Inventory
1,4-dimethylbenzene
C&L Inventory, Registration dossier
1,4-Dimethylbenzene
Registration dossier
1,4-Dimethylbenzol
C&L Inventory
1,4-xylene
C&L Inventory, Registration dossier, Other
Benzene, 1,4-dimethyl-
C&L Inventory
Not applicable
Registration dossier
P-XYLENE
C&L Inventory, Registration dossier
P-xylene
C&L Inventory, Registration dossier
p-xylene grezzo
Registration dossier
p-Xylol
C&L Inventory
PARA XYLENE
Registration dossier
para-xylene
Registration dossier
paraxylene
Registration dossier
Xylene
C&L Inventory
Xylene, p-
C&L Inventory
Not applicable
Registration dossier
P-Xylene
Registration dossier
Para Xylene
Registration dossier
Para-Xylene
Registration dossier
paraxylene
Registration dossier
Paraxylenes
Registration dossier
PX
Registration dossier
106-42-3
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Ambient Air Quality Directive, Annex X - Ozone Precursor Substances, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Occupational Exposure Limits - 1st list - Indicative OELVs, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties
601-022-00-9
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 5 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [5]
C Substance type
Organic (100%) [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 10 studies submitted
  • 5 studies processed
R Melting / freezing point
-47.8 - 13.25 °C @ 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-20 °C

Boiling point

Study results
  • 10 studies submitted
  • 5 studies processed
R Boiling point
138.2 - 144.5 °C @ 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
141 °C

Density

Study results
  • 10 studies submitted
  • 5 studies processed
R Density
0.86 - 0.88 g/cm³ @ 25 °C [3]
R Relative density
0.86 @ 25 °C [2]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.87

Vapour pressure

Study results
  • 10 studies submitted
  • 5 studies processed
R Vapour pressure
12.824 - 14.272 hPa @ 26.667 - 32.222 °C [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
10.52 hPa @ 25 °C

Partition coefficient

Study results
  • 15 studies submitted
  • 5 studies processed
R Log Pow
3.12 - 3.2 @ 20 °C and pH 7 [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 6 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
3.16 @ 20 °C

Water solubility

Study results
  • 10 studies submitted
  • 5 studies processed
R Water solubility (mass/vol.)
146 - 170.5 mg/L @ 25 °C and pH 7 [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
157.5 mg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
28.75 mN/m

Flash point

Study results
  • 10 studies submitted
  • 5 studies processed
R Flash point
27 - 32 °C @ 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
28.7 °C

Auto flammability

Study results
  • 5 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
463 - 528 °C @ 101.3 kPa [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
506 °C

Flammability

Study results
  • 5 studies submitted
  • 5 studies processed
C Interpretation of results
Extremely flammable (100%) [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 5 studies submitted
  • 5 studies processed
R dynamic viscosity (in mPa s)
0.581 - 0.76 [5]

Type of Study provided
Studies with data
Key study 3 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
0.75 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 12 studies submitted
  • 12 studies processed
R Dissipation half life (DT50)
18.936 - 39.432 h [12]

Type of Study provided
Studies with data
Key study 5 7
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
24 h

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 20 studies submitted
  • 12 studies processed
R BOD5
1.4 - 2.53 g O2/g test material [5]
R COD
2.56 - 2.91 g O2/g test material [5]
C Interpretation of results
Readily biodegradable (78%), Readily biodegradable but failing the 10-day window (22%) [9]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence 7 6 3
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 4 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
25.9

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 2 studies processed
R Koc
537 dimensionless [2]
R log Koc
2.73 dimensionless [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
537

Henrys law constant (H)

Study results
  • 12 studies submitted
  • 7 studies processed
R H - (pressure) m³/mol
425 - 728 Pa m³/mol @ 25 °C [26]

Type of Study provided
Studies with data
Key study 3 4
Supporting study 3 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
623 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 44 µg/L (1)
Intermittent releases (freshwater) 10 µg/L (1)
Marine water 4.4 µg/L (1)
Intermittent releases (marine water) 1 µg/L (1)
Sewage treatment plant (STP) 1.6 mg/L (1)
Sediment (freshwater) 2.52 mg/kg sediment dw (1)
Sediment (marine water) 252 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 852 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 20 studies submitted
  • 12 studies processed
P/RResults
LC50 (4 days) 2.6 - 8.4 mg/L [5]
LL50 (72 h) 4.667 - 5.921 mg/L [7]

Type of Study provided
Studies with data
Key study 3 5 4
Supporting study 5 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
NOEC (35 days) 714 µg/L [1]
LOEC (35 days) 1.29 mg/L [1]
NOELR (21 days) 894 - 1 134 µg/L [7]

Type of Study provided
Studies with data
Key study 1 3 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 16 studies submitted
  • 12 studies processed
P/RResults
IC50 (24 h) 1 - 4.7 mg/L [5]
LC50 (48 h) 10.389 mg/L [2]
LL50 (48 h) 8.73 - 11.076 mg/L [5]

Type of Study provided
Studies with data
Key study 3 4 5
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 10 studies processed
P/RResults
NOEC (21 days) 1.57 mg/L [1]
NOEC (7 days) 1.17 mg/L [2]
LOEC (21 days) 3.16 mg/L [1]
EC10 (21 days) 1.91 mg/L [1]
NOELR (21 days) 1.672 - 2.122 mg/L [7]

Type of Study provided
Studies with data
Key study 2 4 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 18 studies submitted
  • 12 studies processed
P/RResults
EC50 (73 h) 2.2 - 4.36 mg/L [2]
EC50 (72 h) 4.7 - 4.9 mg/L [4]
NOEC (73 h) 440 µg/L [1]
EC10 (73 h) 720 - 1 900 µg/L [2]
EC90 (73 h) 4.4 - 10 mg/L [2]

Type of Study provided
Studies with data
Key study 3 4 5
Supporting study 4 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
2.2 mg/L
EC10 or NOEC for freshwater algae
440 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 16 studies submitted
  • 5 studies processed
P/RResults
NOEC (28 days) 16 - 16.2 mg/L [5]

Type of Study provided
Studies with data
Key study 3 5 4
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
16 mg/L

Sediment toxicity

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
22.489 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
4.308 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 10 studies submitted
  • 3 studies processed
P/RResults
NOEC (56 days) 42.6 - 93.1 mg/kg soil dw [8]
LOEC (56 days) 71.1 - 152 mg/kg soil dw [8]
EC10 (56 days) 67.5 - 70.8 mg/kg soil dw [3]
LC10 (56 days) 71.4 - 88.8 mg/kg soil dw [3]
EC50 (56 days) 88.8 - 93.2 mg/kg soil dw [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 4 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
88.8 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
42.6 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 9 studies submitted
  • 7 studies processed
P/RResults
other: (28 days) 2.379 - 41.844 mg/kg soil dw [14]

Type of Study provided
Studies with data
Key study 3 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
12.417 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
2.379 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 13 studies submitted
  • 2 studies processed
P/RResults
EC25 (14 days) 90 - 421 mg/kg soil dw [8]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3 6 4
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
36.646 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
7.02 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EC25 (28 days) 1 g/kg soil dw [4]
EC25 (7 days) 669 mg/kg soil dw [2]
EC50 (28 days) 1 g/kg soil dw [4]
EC50 (7 days) 867 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50
867 mg/kg soil dw

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 221 mg/m³ neurotoxicity
Acute /short term: (DNEL) 442 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 221 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 442 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 212 mg/kg bw/day neurotoxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 65.3 mg/m³ neurotoxicity
Acute /short term: (DNEL) 260 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 65.3 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 260 mg/m³ neurotoxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 125 mg/kg bw/day neurotoxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.5 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 10 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 2 3 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 15 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 10 studies submitted
  • 6 studies processed
P/RResults
LD50 3 523 - 6 631 mg/kg bw (rat) [6]
LD50 5 251 - 5 627 mg/kg bw (mouse) [4]
M/CInterpretations of results
Not classified [6]

Type of Study provided
oral
Studies with data
Key study 3 3
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 21 studies submitted
  • 5 studies processed
P/RResults
LC50 (4 h) 5 922 - 6 700 ppm (rat) [7]
M/CInterpretations of results
Not classified [5]

inhalation
Studies with data
Key study 4 2
Supporting study 9 6
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 4 studies processed
P/RResults
LD50 12 126 mg/kg bw (rabbit) [2]
LD50 5 mL/kg bw (rabbit) [2]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study 1 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 3 523 mg/kg bw
Inhalation route:
Adverse effect observed LC50 27.124 mg/L air
Dermal route:
Adverse effect observed LD50 12 126 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 5 4
Weight of evidence 1 1
Other
Data waiving
no waivers
Study data: eye
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 3 3
Weight of evidence 1 1
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study 1 1
Weight of evidence 1 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 13 studies submitted
  • 5 studies processed
P/RResults
NOAEL (rat): 100 - 300 mg/kg bw/day [9]

Type of Study provided
Study data: oral
Studies with data
Key study 3 2
Supporting study 4 4
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 10 studies submitted
  • 5 studies processed
P/RResults
NOAEC (rat): 450 - 1 800 ppm [10]

Study data: inhalation
Studies with data
Key study 4 2
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 3 515 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 29 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 9 7
Supporting study 8 5
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 5 4
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 500 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 5 4
Supporting study 16 11
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rabbit)
Inhalation route:
No adverse effect observed BMCL10 4 190 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study 6 5
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant