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Result 1-7 of 7 for mutagenicity

Chemical legislation,REACH Full entry
EN
mutagenicity  
Definition Ability of a chemical to cause changes in the genetic material.


Chemical legislation,CLP Full entry
EN
mutagen  
 
Definition An agent giving rise to an increased occurrence of mutations in populations of cells and /or organisms.


Chemical legislation,REACH Full entry
EN
mutagen category 1  
   
mutagenic category 1  
 
Definition Substances known to be mutagenic to humans. There is sufficient evidence to establish a causal association between human exposure to a substance and heritable genetic damage.


Chemical legislation,REACH Full entry
EN
mutagen category 2  
   
mutagenic category 2  
 
Definition Substances which should be regarded as if they are mutagenic to humans. There is sufficient evidence to provide a strong presumption that human exposure to the substance may result in the development of heritable genetic damage (generally on the basis of appropriate animal studies).


Chemical legislation,REACH Full entry
EN
mutagen category 3  
   
mutagenic category 3  
 
Definition Substances which cause concern for humans owing to possible mutagenic effects. There is evidence from appropriate mutagenicity studies, but this is insufficient to place the substance in Category 2.


Chemical legislation,CLP Full entry
EN
germ cell mutagenicity  
   
Definition Ability of a chemical to cause heritable changes in the genetic material in germ cells.


Chemical legislation Full entry
EN
carcinogenic, mutagenic or toxic to reproduction  
   
CMR  
   
Definition Substances meeting the criteria for classification as carcinogenic, mutagenic or toxic for reproduction category 1 or 2, in accordance with Directive 67/548/EEC, are substances of very high concern2. They may be included in Annex XIV and by that made subject to authorisation requirement. CMRs may be non-threshold (i.e. it is not possible to define a Derived No-Effect Level (DNEL)) or threshold (i.e. it is possible to define a DNEL).