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Definition Ability of a chemical to cause changes in the genetic material.
Definition Ref. Glossary by the Center for Alternatives to Animal Testing, Johns Hopkins University, URL: http://caat.jhsph.edu/public...
Related documents Guidance for the preparation of an Annex XV Dossier on Harmonised Classification and Labelling
Term
Reliability
Term Ref. Corrigendum to Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006, 32006R1907R(01)/EN
Term Note The term ‘mutation’ applies both to heritable genetic changes that may be manifested at the phenotypic level and to the underlying DNA modifications when known (including specific base pair changes and chromosomal translocations). The term ‘mutagenic’ and ‘mutagen’ is used for agents giving rise to an increased occurrence of mutations in populations of cells and/or organisms.
Context For some endpoints, especially mutagenicity and carcinogenicity, the available information may not enable a threshold, and therefore a DNEL, to be established.
Context Ref. Annex I, Corrigendum to Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006, 32006R1907R(01)/EN
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